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Thbd thrombomodulin [ Mus musculus (house mouse) ]

Gene ID: 21824, updated on 8-Feb-2024

Summary

Official Symbol
Thbdprovided by MGI
Official Full Name
thrombomodulinprovided by MGI
Primary source
MGI:MGI:98736
See related
Ensembl:ENSMUSG00000074743 AllianceGenome:MGI:98736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TM; CD141
Summary
Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Acts upstream of or within female pregnancy. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; lung; and skeleton. Used to study thrombophilia. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Thbd in Genome Data Viewer
Location:
2 G3; 2 73.45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148246391..148250108, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148404471..148408188, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39957 Neighboring gene STARR-seq mESC enhancer starr_05968 Neighboring gene STARR-positive B cell enhancer ABC_E9205 Neighboring gene STARR-seq mESC enhancer starr_05969 Neighboring gene somatostatin receptor 4 Neighboring gene STARR-seq mESC enhancer starr_05970 Neighboring gene STARR-positive B cell enhancer ABC_E5997 Neighboring gene STARR-positive B cell enhancer ABC_E2051 Neighboring gene CD93 antigen Neighboring gene STARR-seq mESC enhancer starr_05971 Neighboring gene predicted gene, 46770 Neighboring gene STARR-seq mESC enhancer starr_05973

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (12)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of serine-type endopeptidase complex ISO
Inferred from Sequence Orthology
more info
 
located_in vacuolar membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thrombomodulin
Names
fetomodulin
snoRNA MBII-339

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009378.3NP_033404.1  thrombomodulin precursor

    See identical proteins and their annotated locations for NP_033404.1

    Status: VALIDATED

    Source sequence(s)
    AL935149
    Consensus CDS
    CCDS16838.1
    UniProtKB/Swiss-Prot
    P15306
    UniProtKB/TrEMBL
    Q543W3, Q8BJB5
    Related
    ENSMUSP00000096877.4, ENSMUST00000099270.5
    Conserved Domains (5) summary
    pfam06247
    Location:346467
    Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28
    pfam07645
    Location:324360
    EGF_CA; Calcium-binding EGF domain
    pfam09064
    Location:405438
    Tme5_EGF_like; Thrombomodulin like fifth domain, EGF-like
    pfam14670
    Location:244279
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl02432
    Location:30169
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    148246391..148250108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)