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Nup153 nucleoporin 153 [ Mus musculus (house mouse) ]

Gene ID: 218210, updated on 30-Apr-2024

Summary

Official Symbol
Nup153provided by MGI
Official Full Name
nucleoporin 153provided by MGI
Primary source
MGI:MGI:2385621
See related
Ensembl:ENSMUSG00000021374 AllianceGenome:MGI:2385621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B130015D15Rik
Summary
Predicted to enable several functions, including nuclear localization sequence binding activity; small GTPase binding activity; and zinc ion binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including negative regulation of RNA export from nucleus; nuclear pore complex assembly; and nucleocytoplasmic transport. Predicted to be located in annulate lamellae; cytosol; and nucleus. Predicted to be part of nuclear pore nuclear basket. Is expressed in embryo; lung; neural tube; and retina. Orthologous to human NUP153 (nucleoporin 153). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 42.1), thymus adult (RPKM 15.1) and 28 other tissues See more
Orthologs
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Genomic context

See Nup153 in Genome Data Viewer
Location:
13 A5; 13 24.3 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (46833369..46890682, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (46679902..46727849, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35110 Neighboring gene STARR-seq mESC enhancer starr_34413 Neighboring gene STARR-seq mESC enhancer starr_34414 Neighboring gene cyclase associated actin cytoskeleton regulatory protein 2 Neighboring gene VISTA enhancer mm132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46712127-46712352 Neighboring gene STARR-seq mESC enhancer starr_34416 Neighboring gene family with sequence similarity 8, member A1 Neighboring gene STARR-seq mESC enhancer starr_34420 Neighboring gene STARR-positive B cell enhancer ABC_E9876 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46831628-46831815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46831840-46832060 Neighboring gene predicted gene, 46412 Neighboring gene kinesin family member 13A Neighboring gene predicted gene, 24620 Neighboring gene STARR-seq mESC enhancer starr_34424 Neighboring gene predicted gene, 22960

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of RNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear pore complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in annulate lamellae ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasmic side of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear pore complex protein Nup153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175749.2NP_786925.2  nuclear pore complex protein Nup153

    Status: VALIDATED

    Source sequence(s)
    AK031006, AK044947, AK086847, BM950067, CA326562, CF897724, CF898039, CK638380
    Consensus CDS
    CCDS26486.1
    UniProtKB/TrEMBL
    E9Q3G8, Q80WR0
    Related
    ENSMUSP00000021803.9, ENSMUST00000021803.10
    Conserved Domains (4) summary
    sd00025
    Location:658677
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:718746
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:114625
    Nup153; Nucleoporin Nup153-like
    pfam10599
    Location:13721462
    Nup_retrotrp_bd; Retro-transposon transporting motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    46833369..46890682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157992.1XP_036013885.1  nuclear pore complex protein Nup153 isoform X1

    UniProtKB/TrEMBL
    Q80WR0
    Conserved Domains (4) summary
    sd00025
    Location:367386
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam10599
    Location:10811171
    Nup_retrotrp_bd; Retro-transposon transporting motif
    pfam00641
    Location:427455
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:1326
    Nup153; Nucleoporin Nup153-like
  2. XM_036157993.1XP_036013886.1  nuclear pore complex protein Nup153 isoform X2

    UniProtKB/TrEMBL
    Q80UN3
    Conserved Domains (4) summary
    sd00025
    Location:147166
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam10599
    Location:861951
    Nup_retrotrp_bd; Retro-transposon transporting motif
    pfam00641
    Location:207235
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:1106
    Nup153; Nucleoporin Nup153-like