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Tgif1 TGFB-induced factor homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 21815, updated on 22-Nov-2020

Summary

Official Symbol
Tgif1provided by MGI
Official Full Name
TGFB-induced factor homeobox 1provided by MGI
Primary source
MGI:MGI:1194497
See related
Ensembl:ENSMUSG00000047407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tgi; Tgif; AA959811; AI462167
Expression
Ubiquitous expression in ovary adult (RPKM 15.8), bladder adult (RPKM 9.9) and 24 other tissues See more
Orthologs

Genomic context

See Tgif1 in Genome Data Viewer
Location:
17; 17 E1.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71151200..71160527, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (70844205..70853532, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (71193545..71202872, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene DLG associated protein 1 Neighboring gene predicted gene, 41609 Neighboring gene predicted gene, 41610 Neighboring gene predicted gene, 36856 Neighboring gene microRNA 1195

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
JUN kinase binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
co-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homeobox protein TGIF1
Names
5'-TG-3'-interacting factor 1
TALE family homeobox
TG interacting factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164074.1NP_001157546.1  homeobox protein TGIF1 isoform c

    See identical proteins and their annotated locations for NP_001157546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 all encode the same isoform.
    Source sequence(s)
    AC079441, AK160193, BY096128
    Consensus CDS
    CCDS50174.1
    UniProtKB/Swiss-Prot
    P70284
    UniProtKB/TrEMBL
    Q3TVD4
    Related
    ENSMUSP00000113192.1, ENSMUST00000118283.7
    Conserved Domains (1) summary
    pfam05920
    Location:3372
    Homeobox_KN; Homeobox KN domain
  2. NM_001164075.1NP_001157547.1  homeobox protein TGIF1 isoform a

    See identical proteins and their annotated locations for NP_001157547.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC079441, CT009715
    Consensus CDS
    CCDS50175.1
    UniProtKB/TrEMBL
    G3UWC5
    Related
    ENSMUSP00000130930.2, ENSMUST00000166395.8
    Conserved Domains (1) summary
    pfam05920
    Location:86125
    Homeobox_KN; Homeobox KN domain
  3. NM_001164076.1NP_001157548.1  homeobox protein TGIF1 isoform c

    See identical proteins and their annotated locations for NP_001157548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 all encode the same isoform.
    Source sequence(s)
    AC079441
    Consensus CDS
    CCDS50174.1
    UniProtKB/Swiss-Prot
    P70284
    UniProtKB/TrEMBL
    Q3TVD4
    Related
    ENSMUSP00000127139.1, ENSMUST00000172229.7
    Conserved Domains (1) summary
    pfam05920
    Location:3372
    Homeobox_KN; Homeobox KN domain
  4. NM_001164077.1NP_001157549.1  homeobox protein TGIF1 isoform c

    See identical proteins and their annotated locations for NP_001157549.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3, 4, and 5 all encode the same isoform.
    Source sequence(s)
    AC079441
    Consensus CDS
    CCDS50174.1
    UniProtKB/Swiss-Prot
    P70284
    UniProtKB/TrEMBL
    Q3TVD4
    Conserved Domains (1) summary
    pfam05920
    Location:3372
    Homeobox_KN; Homeobox KN domain
  5. NM_009372.3NP_033398.2  homeobox protein TGIF1 isoform b

    See identical proteins and their annotated locations for NP_033398.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a distinct start codon, compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC079441, AK008909, AK160193, CD563532
    Consensus CDS
    CCDS37683.1
    UniProtKB/Swiss-Prot
    P70284
    UniProtKB/TrEMBL
    Q3TVD4
    Related
    ENSMUSP00000060512.8, ENSMUST00000059775.14
    Conserved Domains (1) summary
    pfam05920
    Location:5392
    Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    71151200..71160527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160474.1XP_036016367.1  homeobox protein TGIF1 isoform X2

    Conserved Domains (1) summary
    pfam05920
    Location:5291
    Homeobox_KN; Homeobox KN domain
  2. XM_011246363.4XP_011244665.1  homeobox protein TGIF1 isoform X1

    Conserved Domains (1) summary
    pfam05920
    Location:5695
    Homeobox_KN; Homeobox KN domain
  3. XM_006524032.4XP_006524095.1  homeobox protein TGIF1 isoform X3

    See identical proteins and their annotated locations for XP_006524095.1

    UniProtKB/Swiss-Prot
    P70284
    UniProtKB/TrEMBL
    Q3TVD4
    Conserved Domains (1) summary
    pfam05920
    Location:3372
    Homeobox_KN; Homeobox KN domain
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