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Tgfbi transforming growth factor, beta induced [ Mus musculus (house mouse) ]

Gene ID: 21810, updated on 3-Jan-2023

Summary

Official Symbol
Tgfbiprovided by MGI
Official Full Name
transforming growth factor, beta inducedprovided by MGI
Primary source
MGI:MGI:99959
See related
Ensembl:ENSMUSG00000035493 AllianceGenome:MGI:99959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
68kDa; big-h3; Beta-ig
Summary
Enables extracellular matrix binding activity. Acts upstream of or within cell adhesion and extracellular matrix organization. Located in extracellular matrix and extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; heart and pericardium; sensory organ; and skeleton. Used to study corneal dystrophy. Human ortholog(s) of this gene implicated in corneal dystrophy (multiple). Orthologous to human TGFBI (transforming growth factor beta induced). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 81.3), bladder adult (RPKM 58.4) and 22 other tissues See more
Orthologs
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Genomic context

See Tgfbi in Genome Data Viewer
Location:
13 B1; 13 30.09 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (56757399..56787172)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (56609586..56639359)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 21 Neighboring gene leukocyte cell-derived chemotaxin 2 Neighboring gene RIKEN cDNA 2010203P06 gene Neighboring gene predicted gene, 32965 Neighboring gene predicted gene, 32910 Neighboring gene predicted gene, 33019

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150270

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix binding IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in localization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transforming growth factor-beta-induced protein ig-h3
Names
transforming growth factor, beta induced, 68 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009369.5NP_033395.1  transforming growth factor-beta-induced protein ig-h3 precursor

    See identical proteins and their annotated locations for NP_033395.1

    Status: VALIDATED

    Source sequence(s)
    AC132886, AC132901
    Consensus CDS
    CCDS36680.1
    UniProtKB/Swiss-Prot
    P82198, Q3U9R1
    UniProtKB/TrEMBL
    A1L353
    Related
    ENSMUSP00000037719.9, ENSMUST00000045173.10
    Conserved Domains (1) summary
    pfam02469
    Location:514634
    Fasciclin; Fasciclin domain

RNA

  1. NR_155548.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK135536
    Related
    ENSMUST00000225600.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    56757399..56787172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)