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Tsc22d1 TSC22 domain family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 21807, updated on 26-Sep-2022

Summary

Official Symbol
Tsc22d1provided by MGI
Official Full Name
TSC22 domain family, member 1provided by MGI
Primary source
MGI:MGI:109127
See related
Ensembl:ENSMUSG00000022010 AllianceGenome:MGI:109127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tsc; Egr5; Tsc22; TSC-22; Gm19597; Tgfb1i4
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of apoptotic process; positive regulation of apoptotic process; and positive regulation of cell population proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TSC22D1 (TSC22 domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 53.8), CNS E14 (RPKM 43.9) and 27 other tissues See more
Orthologs
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Genomic context

See Tsc22d1 in Genome Data Viewer
Location:
14 D3; 14 40.44 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76652401..76745205)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (76414961..76507765)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1502 Neighboring gene predicted gene, 41215 Neighboring gene RIKEN cDNA 4930444M15 gene Neighboring gene predicted gene, 36845 Neighboring gene stress-associated endoplasmic reticulum protein family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TSC22 domain family protein 1
Names
Tgfb-stimulated clone 22 homolog
Tsc22-related inducible leucine zipper 1b
regulatory protein Tsc22
transforming growth factor beta 1 induced transcript 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177751.2NP_001171222.1  TSC22 domain family protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC142266, AI841546, AK147039, BY720238
    Consensus CDS
    CCDS49545.1
    UniProtKB/TrEMBL
    D3YW86, Q3UXU0
    Related
    ENSMUSP00000099140.3, ENSMUST00000101618.9
    Conserved Domains (1) summary
    pfam01166
    Location:2268
    TSC22; TSC-22/dip/bun family
  2. NM_001310646.1NP_001297575.1  TSC22 domain family protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001297575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate splice structure in its 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC134842, AI841546, AW546174, CX220910
    Consensus CDS
    CCDS79344.1
    UniProtKB/TrEMBL
    D3Z0V7
    Related
    ENSMUSP00000106513.2, ENSMUST00000110888.8
    Conserved Domains (2) summary
    PHA03247
    Location:486796
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:910956
    TSC22; TSC-22/dip/bun family
  3. NM_001310647.1NP_001297576.1  TSC22 domain family protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001297576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks the 5' and central coding regions, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (5) is significantly shorter than isoform 1.
    Source sequence(s)
    AI841546, AW546174, CX220910
    Consensus CDS
    CCDS79345.1
    UniProtKB/TrEMBL
    A0A6P5R2C4, H3BLI9
    Related
    ENSMUSP00000135296.2, ENSMUST00000177207.2
    Conserved Domains (1) summary
    cl40461
    Location:174
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
  4. NM_009366.4NP_033392.1  TSC22 domain family protein 1 isoform 2

    See identical proteins and their annotated locations for NP_033392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI841546, AK147039
    Consensus CDS
    CCDS27286.1
    UniProtKB/Swiss-Prot
    P62500
    UniProtKB/TrEMBL
    A0A6P5R047, A0A8C6N0A6, Q3UXU0
    Related
    ENSMUSP00000022587.10, ENSMUST00000022587.10
    Conserved Domains (1) summary
    cd21938
    Location:53131
    ZIP_TSC22D1; leucine zipper domain found in TSC22 domain family protein 1
  5. NM_207652.3NP_997535.2  TSC22 domain family protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI841546, AK147039, BC058660
    Consensus CDS
    CCDS27285.2
    UniProtKB/Swiss-Prot
    P62500
    UniProtKB/TrEMBL
    E9QLZ1, Q3UXU0
    Related
    ENSMUSP00000044517.9, ENSMUST00000048371.15
    Conserved Domains (2) summary
    PHA03247
    Location:568878
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:9921038
    TSC22; TSC-22/dip/bun family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    76652401..76745205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315943.2XP_017171432.1  TSC22 domain family protein 1 isoform X2

    UniProtKB/TrEMBL
    E9QLZ1
    Conserved Domains (2) summary
    PHA03247
    Location:568878
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:9921038
    TSC22; TSC-22/dip/bun family
  2. XM_017315942.2XP_017171431.1  TSC22 domain family protein 1 isoform X2

    UniProtKB/TrEMBL
    E9QLZ1
    Conserved Domains (2) summary
    PHA03247
    Location:568878
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:9921038
    TSC22; TSC-22/dip/bun family
  3. XM_006518803.4XP_006518866.1  TSC22 domain family protein 1 isoform X6

    See identical proteins and their annotated locations for XP_006518866.1

    UniProtKB/TrEMBL
    D3Z0V7
    Conserved Domains (2) summary
    PHA03247
    Location:486796
    PHA03247; large tegument protein UL36; Provisional
    pfam01166
    Location:910956
    TSC22; TSC-22/dip/bun family
  4. XM_017315945.2XP_017171434.1  TSC22 domain family protein 1 isoform X5

    Conserved Domains (1) summary
    PHA03247
    Location:568878
    PHA03247; large tegument protein UL36; Provisional
  5. XM_006518799.3XP_006518862.1  TSC22 domain family protein 1 isoform X1

    Conserved Domains (1) summary
    PHA03247
    Location:568878
    PHA03247; large tegument protein UL36; Provisional
  6. XM_006518801.3XP_006518864.1  TSC22 domain family protein 1 isoform X4

    Conserved Domains (1) summary
    PHA03247
    Location:568878
    PHA03247; large tegument protein UL36; Provisional
  7. XM_006518800.3XP_006518863.1  TSC22 domain family protein 1 isoform X3

    Conserved Domains (1) summary
    PHA03247
    Location:568878
    PHA03247; large tegument protein UL36; Provisional
  8. XM_036158535.1XP_036014428.1  TSC22 domain family protein 1 isoform X7

    Conserved Domains (1) summary
    PHA03247
    Location:486796
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_004938376.1 RNA Sequence

  2. XR_003950835.1 RNA Sequence

  3. XR_001781104.2 RNA Sequence

  4. XR_001781105.2 RNA Sequence

  5. XR_383154.3 RNA Sequence

  6. XR_003950836.1 RNA Sequence

  7. XR_004938375.1 RNA Sequence

  8. XR_383156.3 RNA Sequence

  9. XR_003950837.1 RNA Sequence