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Tfpi tissue factor pathway inhibitor [ Mus musculus (house mouse) ]

Gene ID: 21788, updated on 12-Mar-2023

Summary

Official Symbol
Tfpiprovided by MGI
Official Full Name
tissue factor pathway inhibitorprovided by MGI
Primary source
MGI:MGI:1095418
See related
Ensembl:ENSMUSG00000027082 AllianceGenome:MGI:1095418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EPI; LACI; A630013F22Rik
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of blood coagulation. Predicted to act upstream of or within blood coagulation. Located in extracellular space. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; lung; and retina. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 120.5) and heart adult (RPKM 7.2) See more
Orthologs
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Genomic context

See Tfpi in Genome Data Viewer
Location:
2; 2 D
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84263199..84307119, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84432855..84476775, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54167 Neighboring gene calcitonin receptor-like Neighboring gene VISTA enhancer mm1324 Neighboring gene predicted gene 13710

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tissue factor pathway inhibitor
Names
extrinsic pathway inhibitor
lipoprotein-associated coagulation inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177319.1NP_001170790.1  tissue factor pathway inhibitor isoform b precursor

    See identical proteins and their annotated locations for NP_001170790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AK034752, AL845305, BY307762
    Consensus CDS
    CCDS50620.1
    UniProtKB/TrEMBL
    Q8BSB7
    Related
    ENSMUSP00000107343.2, ENSMUST00000111714.8
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:120171
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  2. NM_001177320.1NP_001170791.1  tissue factor pathway inhibitor isoform b precursor

    See identical proteins and their annotated locations for NP_001170791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AK034752, AL845305
    Consensus CDS
    CCDS50620.1
    UniProtKB/TrEMBL
    Q8BSB7
    Related
    ENSMUSP00000088235.4, ENSMUST00000090732.10
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:120171
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  3. NM_001355271.1NP_001342200.1  tissue factor pathway inhibitor isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AL845305
    Consensus CDS
    CCDS16185.1
    UniProtKB/Swiss-Prot
    Q9Z2U8
    Related
    ENSMUSP00000107351.2, ENSMUST00000111722.8
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:224276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  4. NM_001355273.1NP_001342202.1  tissue factor pathway inhibitor isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AL845305
    Consensus CDS
    CCDS16185.1
    UniProtKB/Swiss-Prot
    Q9Z2U8
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:224276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  5. NM_011576.1NP_035706.1  tissue factor pathway inhibitor isoform a precursor

    See identical proteins and their annotated locations for NP_035706.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AK028356
    Consensus CDS
    CCDS16185.1
    UniProtKB/Swiss-Prot
    O54819, Q9Z2U8
    Related
    ENSMUSP00000028487.4, ENSMUST00000028487.10
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:224276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84263199..84307119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160427.1XP_036016320.1  tissue factor pathway inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2U8
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:224276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  2. XM_030249392.2XP_030105252.1  tissue factor pathway inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2U8
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:224276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  3. XM_006499145.3XP_006499208.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_006499208.1

    UniProtKB/Swiss-Prot
    O54819, Q9Z2U8
    Related
    ENSMUSP00000107347.2, ENSMUST00000111718.8
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:224276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  4. XM_030249395.1XP_030105255.1  tissue factor pathway inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2U8
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:224276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  5. XM_036160428.1XP_036016321.1  tissue factor pathway inhibitor isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2U8
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:224276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  6. XM_006499149.5XP_006499212.1  tissue factor pathway inhibitor isoform X2

    UniProtKB/Swiss-Prot
    O54819
    Related
    ENSMUSP00000122776.2, ENSMUST00000150261.8
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:120171
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
  7. XM_006499150.4XP_006499213.1  tissue factor pathway inhibitor isoform X3

    See identical proteins and their annotated locations for XP_006499213.1

    UniProtKB/TrEMBL
    Q8BSB7
    Conserved Domains (2) summary
    cd00109
    Location:48101
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:120171
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain