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Terc telomerase RNA component [ Mus musculus (house mouse) ]

Gene ID: 21748, updated on 8-Feb-2024

Summary

Official Symbol
Tercprovided by MGI
Official Full Name
telomerase RNA componentprovided by MGI
Primary source
MGI:MGI:109558
See related
Ensembl:ENSMUSG00000118406 AllianceGenome:MGI:109558
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mTR; mTER
Summary
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Telomerase may also participate in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. In contrast with human telomerase, murine telomerase is expressed in many normal postnatal somatic tissues. [provided by RefSeq, Jul 2008]
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Genomic context

See Terc in Genome Data Viewer
Location:
3 F2.1; 3 41.82 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96321753..96322149, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96414437..96414833, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit, pseudogene 1 Neighboring gene nuclear encoded tRNA histidine 6 (anticodon GTG) Neighboring gene STARR-seq mESC enhancer starr_08427 Neighboring gene predicted gene, 24136 Neighboring gene nuclear encoded tRNA glycine 6 (anticodon CCC)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_001579.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AF221922
    Related
    ENSMUST00000238714.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96321753..96322149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)