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Git1 GIT ArfGAP 1 [ Mus musculus (house mouse) ]

Gene ID: 216963, updated on 21-Apr-2024

Summary

Official Symbol
Git1provided by MGI
Official Full Name
GIT ArfGAP 1provided by MGI
Primary source
MGI:MGI:1927140
See related
Ensembl:ENSMUSG00000011877 AllianceGenome:MGI:1927140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cat-1; p95Cat
Summary
Predicted to enable several functions, including GTPase activator activity; gamma-tubulin binding activity; and small GTPase binding activity. Predicted to be a structural constituent of postsynaptic specialization. Involved in several processes, including cell redox homeostasis; modulation of chemical synaptic transmission; and nervous system development. Acts upstream of or within ephrin receptor signaling pathway. Located in calyx of Held and postsynapse. Is expressed in embryo. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 225.3), cortex adult (RPKM 49.2) and 23 other tissues See more
Orthologs
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Genomic context

Location:
11 B5; 11 46.61 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77384114..77398600)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77493288..77507774)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coronin 6 Neighboring gene microRNA mir-12181 Neighboring gene ankyrin repeat domain 13b Neighboring gene STARR-seq mESC enhancer starr_30056 Neighboring gene transformation related protein 53 inducible protein 13 Neighboring gene abhydrolase domain containing 15 Neighboring gene predicted gene 10392

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of postsynaptic specialization ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendritic spine development ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within immunological synapse formation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in intramembranous ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ARF protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ARF protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle recycling IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in calyx of Held IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ARF GTPase-activating protein GIT1
Names
ARF GAP GIT1
G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
G protein-coupled receptor kinase-interactor 1
GRK-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004144.1NP_001004144.1  ARF GTPase-activating protein GIT1 isoform 1

    See identical proteins and their annotated locations for NP_001004144.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079870
    Consensus CDS
    CCDS25080.1
    UniProtKB/Swiss-Prot
    Q68FF6
    Related
    ENSMUSP00000037210.4, ENSMUST00000037285.10
    Conserved Domains (6) summary
    sd00045
    Location:137165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:337365
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:649763
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:418482
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
  2. NM_001374758.1NP_001361687.1  ARF GTPase-activating protein GIT1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL607072
    Consensus CDS
    CCDS88196.1
    UniProtKB/TrEMBL
    Q5F258
    Related
    ENSMUSP00000098375.4, ENSMUST00000100812.4
    Conserved Domains (6) summary
    sd00045
    Location:137165
    ANK; ANK repeat [structural motif]
    cd08846
    Location:1111
    ArfGap_GIT1; GIT1 GTPase activating protein for Arf
    pfam08518
    Location:328356
    GIT_SHD; Spa2 homology domain (SHD) of GIT
    pfam12205
    Location:640754
    GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
    pfam12796
    Location:137229
    Ank_2; Ankyrin repeats (3 copies)
    pfam16559
    Location:409473
    GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77384114..77398600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)