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Mrpl22 mitochondrial ribosomal protein L22 [ Mus musculus (house mouse) ]

Gene ID: 216767, updated on 2-Nov-2024

Summary

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Official Symbol
Mrpl22provided by MGI
Official Full Name
mitochondrial ribosomal protein L22provided by MGI
Primary source
MGI:MGI:1333794
See related
Ensembl:ENSMUSG00000020514 AllianceGenome:MGI:1333794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L22mt; Rpml25; HSPC158; MRP-L22; MRP-L25; E030011D16Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; early conceptus; genitourinary system; and gut. Orthologous to human MRPL22 (mitochondrial ribosomal protein L22). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 15.0), liver E14.5 (RPKM 13.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrpl22 in Genome Data Viewer
Location:
11 B1.3; 11 35.89 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58060850..58070406)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58170043..58179580)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10677 Neighboring gene CCR4-NOT transcription complex, subunit 8 Neighboring gene predicted gene 12247 Neighboring gene STARR-seq mESC enhancer starr_29600 Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E5229 Neighboring gene predicted gene 12250 Neighboring gene STARR-positive B cell enhancer ABC_E8877 Neighboring gene interferon gamma induced GTPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Vincentz JW, et al. Circ Res, 2019 Aug 30. PMID 31366290, Free PMC Article
  2. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
  3. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
  4. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  5. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL22m
Names
39S ribosomal protein L22, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403973.1 → NP_001390902.1  large ribosomal subunit protein uL22m precursor

    Status: VALIDATED

    Source sequence(s)
    AL672182, AL928857
    UniProtKB/Swiss-Prot
    Q8BK04, Q8BU88

  2. NM_175001.5 → NP_778166.2  large ribosomal subunit protein uL22m precursor

    See identical proteins and their annotated locations for NP_778166.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AL928857
    Consensus CDS
    CCDS24724.1
    UniProtKB/Swiss-Prot
    Q8BK04, Q8BU88
    Related
    ENSMUSP00000020820.2, ENSMUST00000020820.2
    Conserved Domains (1) summary
    pfam00237
    Location:71 → 172
    Ribosomal_L22; Ribosomal protein L22p/L17e

RNA

  1. NR_166467.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL928857

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58060850..58070406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532854.4 → XP_006532917.1  large ribosomal subunit protein uL22m isoform X2

    See identical proteins and their annotated locations for XP_006532917.1

    Conserved Domains (1) summary
    pfam00237
    Location:1 → 92
    Ribosomal_L22; Ribosomal protein L22p/L17e
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BU88.1 GenPept UniProtKB/Swiss-Prot:Q8BU88

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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