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Prdx2 peroxiredoxin 2 [ Mus musculus (house mouse) ]

Gene ID: 21672, updated on 12-Jan-2019

Summary

Official Symbol
Prdx2provided by MGI
Official Full Name
peroxiredoxin 2provided by MGI
Primary source
MGI:MGI:109486
See related
Ensembl:ENSMUSG00000005161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TR; PRP; TPx; TSA; TDX1; NkefB; PrxII; TPx-B; Tdpx1; Torin; Band-8; AL022839
Expression
Broad expression in liver E14 (RPKM 507.8), liver E14.5 (RPKM 504.3) and 27 other tissues See more
Orthologs

Genomic context

See Prdx2 in Genome Data Viewer
Location:
8 C3; 8 41.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (84969622..84974811)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (87493547..87498212)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene retbindin Neighboring gene ribonuclease H2, large subunit Neighboring gene jun B proto-oncogene Neighboring gene hook microtubule tethering protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity TAS
Traceable Author Statement
more info
PubMed 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
selenium binding TAS
Traceable Author Statement
more info
PubMed 
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thioredoxin peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
thioredoxin peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
thioredoxin peroxidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
removal of superoxide radicals IMP
Inferred from Mutant Phenotype
more info
PubMed 
removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
respiratory burst involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
myelin sheath HDA PubMed 

General protein information

Preferred Names
peroxiredoxin-2
Names
Calpromotin
Prx II-1
Trx dependent peroxide reductase 1
protector protein
thiol-specific antioxidant protein
thioredoxin peroxidase 1
thioredoxin reductase
thioredoxin-dependent peroxide reductase 1
NP_001304314.1
NP_035693.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317385.1NP_001304314.1  peroxiredoxin-2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC163703, AK005225, BC086783, CX238307, DV051712
    Consensus CDS
    CCDS40416.1
    UniProtKB/Swiss-Prot
    Q61171
    UniProtKB/TrEMBL
    Q5M9N9
    Related
    ENSMUSP00000105356.1, ENSMUST00000109734.7
    Conserved Domains (2) summary
    PTZ00253
    Location:1195
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:8179
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  2. NM_011563.6NP_035693.3  peroxiredoxin-2

    See identical proteins and their annotated locations for NP_035693.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK005225, AK008433, CD773819
    Consensus CDS
    CCDS40416.1
    UniProtKB/Swiss-Prot
    Q61171
    Related
    ENSMUSP00000005292.8, ENSMUST00000005292.14
    Conserved Domains (2) summary
    PTZ00253
    Location:1195
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:8179
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    84969622..84974811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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