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Prdx2 peroxiredoxin 2 [ Mus musculus (house mouse) ]

Gene ID: 21672, updated on 8-Feb-2024

Summary

Official Symbol
Prdx2provided by MGI
Official Full Name
peroxiredoxin 2provided by MGI
Primary source
MGI:MGI:109486
See related
Ensembl:ENSMUSG00000005161 AllianceGenome:MGI:109486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TR; PRP; TPx; TSA; TDX1; NkefB; PrxII; TPx-B; Tdpx1; Torin; Band-8
Summary
Predicted to enable thioredoxin peroxidase activity. Involved in positive regulation of blood coagulation and removal of superoxide radicals. Acts upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; regulation of signal transduction; and respiratory burst involved in inflammatory response. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; limb; reproductive system; and sensory organ. Orthologous to human PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 507.8), liver E14.5 (RPKM 504.3) and 27 other tissues See more
Orthologs
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Genomic context

See Prdx2 in Genome Data Viewer
Location:
8 C3; 8 41.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85696251..85701440)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84969622..84974811)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene retbindin Neighboring gene STARR-positive B cell enhancer ABC_E6668 Neighboring gene ribonuclease H2, large subunit Neighboring gene STARR-positive B cell enhancer ABC_E2269 Neighboring gene STARR-seq mESC enhancer starr_22143 Neighboring gene STARR-positive B cell enhancer ABC_E1764 Neighboring gene STARR-positive B cell enhancer ABC_E706 Neighboring gene jun B proto-oncogene Neighboring gene STARR-positive B cell enhancer ABC_E5029 Neighboring gene STARR-positive B cell enhancer ABC_E3789 Neighboring gene hook microtubule tethering protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity TAS
Traceable Author Statement
more info
PubMed 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables selenium binding TAS
Traceable Author Statement
more info
PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thioredoxin peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables thioredoxin peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables thioredoxin peroxidase activity TAS
Traceable Author Statement
more info
PubMed 
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in removal of superoxide radicals IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within respiratory burst involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion HDA PubMed 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
peroxiredoxin-2
Names
Calpromotin
Prx II-1
Trx dependent peroxide reductase 1
protector protein
thiol-specific antioxidant protein
thioredoxin peroxidase 1
thioredoxin reductase
thioredoxin-dependent peroxide reductase 1
thioredoxin-dependent peroxiredoxin 2
NP_001304314.1
NP_035693.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317385.1NP_001304314.1  peroxiredoxin-2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC163703, AK005225, BC086783, CX238307, DV051712
    Consensus CDS
    CCDS40416.1
    UniProtKB/Swiss-Prot
    O88376, Q60796, Q61171, Q9CWJ4, Q9DB49
    UniProtKB/TrEMBL
    Q5M9N9
    Related
    ENSMUSP00000105356.2, ENSMUST00000109734.8
    Conserved Domains (2) summary
    PTZ00253
    Location:1195
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:8179
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  2. NM_011563.6NP_035693.3  peroxiredoxin-2

    See identical proteins and their annotated locations for NP_035693.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK005225, AK008433, CD773819
    Consensus CDS
    CCDS40416.1
    UniProtKB/Swiss-Prot
    O88376, Q60796, Q61171, Q9CWJ4, Q9DB49
    UniProtKB/TrEMBL
    Q5M9N9
    Related
    ENSMUSP00000005292.9, ENSMUST00000005292.15
    Conserved Domains (2) summary
    PTZ00253
    Location:1195
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:8179
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85696251..85701440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)