Clvs2 clavesin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clvs2provided by MGI
Official Full Name: clavesin 2provided by MGI
Primary source: MGI:MGI:2443223
See related: Ensembl:ENSMUSG00000019785 AllianceGenome:MGI:2443223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rlbp1l2; A330019N05Rik
Summary: Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in lysosome organization. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be active in clathrin-coated vesicle; endosome; and trans-Golgi network. Is expressed in embryo. Orthologous to human CLVS2 (clavesin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 5.8), CNS E18 (RPKM 5.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10; 10 A4- B1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (33388282..33500680, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (33512286..33624684, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

Homologs of the Clvs2 gene: The Clvs2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, chicken, zebrafish, mosquito, and frog.
Orthologs from Annotation Pipeline: 478 organisms have orthologs with human gene Clvs2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: clavesin-2

Names: retinaldehyde-binding protein 1-like 2; retinaldehyde-binding protein 1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359139.1 → NP_001346068.1 clavesin-2 isoform 2

Status: VALIDATED

Source sequence(s)

AK039308, AK169009, CD354378

Conserved Domains (1) summary

cd00170
Location:1 → 105

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
NM_175448.4 → NP_780657.1 clavesin-2 isoform 1

See identical proteins and their annotated locations for NP_780657.1

Status: VALIDATED

Source sequence(s)

AK039308, AK169009, CD354378

Consensus CDS

CCDS23770.1

UniProtKB/Swiss-Prot

Q8BG92, Q8BKA5

UniProtKB/TrEMBL

A0A8C6N3M4

Related

ENSMUSP00000019920.7, ENSMUST00000019920.13

Conserved Domains (2) summary

smart01100
Location:29 → 75

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

cd00170
Location:106 → 251

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...