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Adgrg6 adhesion G protein-coupled receptor G6 [ Mus musculus (house mouse) ]

Gene ID: 215798, updated on 9-Mar-2023

Summary

Official Symbol
Adgrg6provided by MGI
Official Full Name
adhesion G protein-coupled receptor G6provided by MGI
Primary source
MGI:MGI:1916151
See related
Ensembl:ENSMUSG00000039116 AllianceGenome:MGI:1916151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DREG; Gm222; Gpr126; 1190004A11Rik
Summary
Enables laminin binding activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; heart trabecula formation; and myelination in peripheral nervous system. Predicted to be located in cell surface; cytoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including heart; lung; otocyst; paraxial mesenchyme; and spleen. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 10.1), lung adult (RPKM 8.1) and 8 other tissues See more
Orthologs
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Genomic context

See Adgrg6 in Genome Data Viewer
Location:
10; 10 A2
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (14278327..14421467, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (14402583..14545723, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24343 Neighboring gene predicted gene, 40603 Neighboring gene VISTA enhancer mm116 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene RIKEN cDNA 1700016L04 gene Neighboring gene vesicle (multivesicular body) trafficking 1 Neighboring gene gap junction protein, epsilon 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables laminin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables laminin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Schwann cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in heart trabecula formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in myelination in peripheral nervous system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
adhesion G-protein coupled receptor G6
Names
G protein coupled receptor Gpr126
G-protein coupled receptor 126
developmentally regulated G-protein-coupled receptor
probable G-protein coupled receptor 126

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002268.3NP_001002268.1  adhesion G-protein coupled receptor G6 precursor

    See identical proteins and their annotated locations for NP_001002268.1

    Status: VALIDATED

    Source sequence(s)
    AB183545, AC118202
    Consensus CDS
    CCDS35848.1
    UniProtKB/Swiss-Prot
    Q6F3F9, Q811E4
    Related
    ENSMUSP00000043055.5, ENSMUST00000041168.6
    Conserved Domains (5) summary
    smart00303
    Location:771822
    GPS; G-protein-coupled receptor proteolytic site domain
    cd00041
    Location:38146
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl02422
    Location:505550
    HRM; Hormone receptor domain
    cl21561
    Location:8331080
    7tm_4; Olfactory receptor
    cl22861
    Location:178337
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    14278327..14421467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245001.1XP_030100861.1  adhesion G-protein coupled receptor G6 isoform X5

    UniProtKB/TrEMBL
    A0A571BEJ4
    Related
    ENSMUSP00000158717.2, ENSMUST00000238680.2
    Conserved Domains (6) summary
    cd00041
    Location:38146
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd14964
    Location:833858
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:771816
    GPS; GPCR proteolysis site, GPS, motif
    cl02422
    Location:505550
    HRM; Hormone receptor domain
    cl22861
    Location:178337
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28897
    Location:8311099
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_006512679.4XP_006512742.1  adhesion G-protein coupled receptor G6 isoform X2

    Conserved Domains (6) summary
    cd00041
    Location:38146
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd14964
    Location:861886
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:799844
    GPS; GPCR proteolysis site, GPS, motif
    cl02422
    Location:533578
    HRM; Hormone receptor domain
    cl22861
    Location:178337
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28897
    Location:8591127
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_006512681.4XP_006512744.1  adhesion G-protein coupled receptor G6 isoform X4

    Conserved Domains (6) summary
    cd00041
    Location:48156
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd14964
    Location:843868
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:781826
    GPS; GPCR proteolysis site, GPS, motif
    cl02422
    Location:515560
    HRM; Hormone receptor domain
    cl22861
    Location:188347
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28897
    Location:8411109
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_036155731.1XP_036011624.1  adhesion G-protein coupled receptor G6 isoform X8

    Conserved Domains (5) summary
    cd00041
    Location:48156
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam01825
    Location:781826
    GPS; GPCR proteolysis site, GPS, motif
    cd14964
    Location:843868
    7tm_GPCRs; TM helix 1 [structural motif]
    cl22861
    Location:188347
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28897
    Location:8411109
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. XM_006512678.4XP_006512741.1  adhesion G-protein coupled receptor G6 isoform X1

    Conserved Domains (6) summary
    cd00041
    Location:48156
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd14964
    Location:871896
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:809854
    GPS; GPCR proteolysis site, GPS, motif
    cl02422
    Location:543588
    HRM; Hormone receptor domain
    cl22861
    Location:188347
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28897
    Location:8691137
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_017313881.2XP_017169370.1  adhesion G-protein coupled receptor G6 isoform X7

    Conserved Domains (5) summary
    cd00041
    Location:48156
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd14964
    Location:871896
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:809854
    GPS; GPCR proteolysis site, GPS, motif
    cl22861
    Location:188347
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28897
    Location:8691137
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. XM_006512680.3XP_006512743.1  adhesion G-protein coupled receptor G6 isoform X3

    Conserved Domains (6) summary
    cd00041
    Location:37145
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd14964
    Location:860885
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:798843
    GPS; GPCR proteolysis site, GPS, motif
    cl02422
    Location:532577
    HRM; Hormone receptor domain
    cl22861
    Location:177336
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28897
    Location:8581126
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  8. XM_006512682.5XP_006512745.1  adhesion G-protein coupled receptor G6 isoform X6

    Related
    ENSMUSP00000146821.2, ENSMUST00000208429.3
    Conserved Domains (5) summary
    cd00041
    Location:48156
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd14964
    Location:871896
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:809854
    GPS; GPCR proteolysis site, GPS, motif
    cl22861
    Location:188347
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl28897
    Location:8691137
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily