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Nav1 neuron navigator 1 [ Mus musculus (house mouse) ]

Gene ID: 215690, updated on 6-Jun-2024

Summary

Official Symbol
Nav1provided by MGI
Official Full Name
neuron navigator 1provided by MGI
Primary source
MGI:MGI:2183683
See related
Ensembl:ENSMUSG00000009418 AllianceGenome:MGI:2183683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm38399; Pomfil3; Unc53h1; mKIAA1151; steerin-1; 9530089B19; 9930003A20Rik; C230080M11Rik
Summary
Acts upstream of or within microtubule bundle formation and neuron migration. Located in axon initial segment and microtubule cytoskeleton. Is expressed in several structures, including central nervous system; embryo mesenchyme; molar; peripheral nervous system ganglion; and sensory organ. Orthologous to human NAV1 (neuron navigator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 16.8), whole brain E14.5 (RPKM 14.4) and 23 other tissues See more
Orthologs
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Genomic context

See Nav1 in Genome Data Viewer
Location:
1; 1 E4
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135362318..135616082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135434580..135688350, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene shisa family member 4 Neighboring gene STARR-seq mESC enhancer starr_02365 Neighboring gene importin 9 Neighboring gene STARR-positive B cell enhancer ABC_E10038 Neighboring gene microRNA 1231 Neighboring gene STARR-seq mESC enhancer starr_02370 Neighboring gene STARR-seq mESC enhancer starr_02371 Neighboring gene predicted gene, 32940 Neighboring gene predicted gene 4793 Neighboring gene STARR-seq mESC enhancer starr_02376 Neighboring gene STARR-seq mESC enhancer starr_02385 Neighboring gene cysteine and glycine-rich protein 1 Neighboring gene predicted gene, 53478 Neighboring gene STARR-positive B cell enhancer ABC_E2561 Neighboring gene STARR-seq mESC enhancer starr_02387 Neighboring gene STARR-seq mESC enhancer starr_02388 Neighboring gene STARR-seq mESC enhancer starr_02389 Neighboring gene pleckstrin homology like domain, family A, member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within microtubule bundle formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon initial segment IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon initial segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuron navigator 1
Names
Steerin1
pore membrane and/or filament-interacting-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427516.1NP_001414445.1  neuron navigator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016814, AC120396, AC120405, AC162441
    UniProtKB/TrEMBL
    A0A589P973
  2. NM_173437.2NP_775613.2  neuron navigator 1 isoform 2

    See identical proteins and their annotated locations for NP_775613.2

    Status: VALIDATED

    Source sequence(s)
    AC016814, AK122458, AK140435, AK153742, CB523329, CN455316
    Consensus CDS
    CCDS35720.1
    UniProtKB/Swiss-Prot
    Q3U5B6, Q68EE8, Q6PB78, Q80TI7, Q8BKG2, Q8BUT5, Q8CH77
    UniProtKB/TrEMBL
    A0A589P973
    Related
    ENSMUSP00000067241.7, ENSMUST00000067414.13
    Conserved Domains (2) summary
    cd00009
    Location:15521659
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00382
    Location:15481659
    AAA; ATPases associated with a variety of cellular activities

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135362318..135616082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252963.1XP_030108823.1  neuron navigator 1 isoform X12

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (2) summary
    smart00382
    Location:15611672
    AAA; ATPases associated with a variety of cellular activities
    TIGR02168
    Location:10901174
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. XM_030252962.2XP_030108822.1  neuron navigator 1 isoform X11

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:15641675
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:10260
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:10931177
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  3. XM_006529378.4XP_006529441.1  neuron navigator 1 isoform X10

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:15811692
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:11101194
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  4. XM_036163515.1XP_036019408.1  neuron navigator 1 isoform X9

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:17801891
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:13151396
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  5. XM_006529377.4XP_006529440.1  neuron navigator 1 isoform X8

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:17831894
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR04211
    Location:13151394
    SH3_and_anchor; SH3 domain protein
  6. XM_006529376.4XP_006529439.1  neuron navigator 1 isoform X7

    UniProtKB/TrEMBL
    A0A589P973
    Related
    ENSMUSP00000140322.3, ENSMUST00000190298.8
    Conserved Domains (3) summary
    smart00382
    Location:17881899
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:13201404
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  7. XM_006529375.4XP_006529438.1  neuron navigator 1 isoform X6

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:17911902
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:13201404
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  8. XM_006529373.4XP_006529436.1  neuron navigator 1 isoform X4

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:18371948
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR04211
    Location:13721451
    SH3_and_anchor; SH3 domain protein
  9. XM_006529372.4XP_006529435.1  neuron navigator 1 isoform X3

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:18401951
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR04211
    Location:13721451
    SH3_and_anchor; SH3 domain protein
  10. XM_006529371.4XP_006529434.1  neuron navigator 1 isoform X2

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:18451956
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:13771461
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  11. XM_006529369.4XP_006529432.1  neuron navigator 1 isoform X1

    See identical proteins and their annotated locations for XP_006529432.1

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:18481959
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:13771461
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  12. XM_006529370.4XP_006529433.1  neuron navigator 1 isoform X1

    See identical proteins and their annotated locations for XP_006529433.1

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:18481959
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:13771461
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  13. XM_017319805.2XP_017175294.1  neuron navigator 1 isoform X1

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:18481959
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:27277
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:13771461
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  14. XM_017319809.1XP_017175298.1  neuron navigator 1 isoform X5

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (3) summary
    smart00382
    Location:18311942
    AAA; ATPases associated with a variety of cellular activities
    PHA03247
    Location:10260
    PHA03247; large tegument protein UL36; Provisional
    TIGR02168
    Location:13601444
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  15. XM_006529379.4XP_006529442.1  neuron navigator 1 isoform X12

    UniProtKB/TrEMBL
    A0A589P973
    Conserved Domains (2) summary
    smart00382
    Location:15611672
    AAA; ATPases associated with a variety of cellular activities
    TIGR02168
    Location:10901174
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  16. XM_006529380.5XP_006529443.1  neuron navigator 1 isoform X13

    Conserved Domains (2) summary
    smart00382
    Location:11541265
    AAA; ATPases associated with a variety of cellular activities
    TIGR02168
    Location:683767
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_004941778.1 RNA Sequence

  2. XR_003954495.1 RNA Sequence

  3. XR_878320.2 RNA Sequence