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Csrnp1 cysteine-serine-rich nuclear protein 1 [ Mus musculus (house mouse) ]

Gene ID: 215418, updated on 21-Apr-2024

Summary

Official Symbol
Csrnp1provided by MGI
Official Full Name
cysteine-serine-rich nuclear protein 1provided by MGI
Primary source
MGI:MGI:2387989
See related
Ensembl:ENSMUSG00000032515 AllianceGenome:MGI:2387989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Axud1; URAX1; taip-3; CSRNP-1; 4931429D10Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including face morphogenesis; platelet-derived growth factor receptor signaling pathway; and roof of mouth development. Located in nucleus. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human CSRNP1 (cysteine and serine rich nuclear protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 18.0), testis adult (RPKM 16.2) and 19 other tissues See more
Orthologs
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Genomic context

Location:
9 F4; 9 71.34 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119800229..119813808, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119971163..119984742, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 48 Neighboring gene golgi reassembly stacking protein 1 Neighboring gene tetratricopeptide repeat domain 21A Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119887435-119887544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119888013-119888122 Neighboring gene STARR-positive B cell enhancer ABC_E6811 Neighboring gene STARR-positive B cell enhancer ABC_E2922 Neighboring gene STARR-positive B cell enhancer ABC_E3866 Neighboring gene predicted gene, 33800 Neighboring gene STARR-seq mESC enhancer starr_25485 Neighboring gene STARR-seq mESC enhancer starr_25486 Neighboring gene STARR-positive B cell enhancer ABC_E9780 Neighboring gene xin actin-binding repeat containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cysteine/serine-rich nuclear protein 1
Names
AXIN1 up-regulated 1
TGF-beta induced apoptosis protein 3
axin-1 up-regulated gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357560.1NP_001344489.1  cysteine/serine-rich nuclear protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC124662, AK029893
    Consensus CDS
    CCDS23620.1
    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Related
    ENSMUSP00000150628.2, ENSMUST00000214058.2
    Conserved Domains (1) summary
    pfam16019
    Location:80303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  2. NM_001357561.1NP_001344490.1  cysteine/serine-rich nuclear protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC124662, AK140213
    Consensus CDS
    CCDS23620.1
    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Related
    ENSMUSP00000035101.8, ENSMUST00000035101.9
    Conserved Domains (1) summary
    pfam16019
    Location:80303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  3. NM_001357562.1NP_001344491.1  cysteine/serine-rich nuclear protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC117245, AC124662
    Consensus CDS
    CCDS23620.1
    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Conserved Domains (1) summary
    pfam16019
    Location:80303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
  4. NM_153287.4NP_695019.1  cysteine/serine-rich nuclear protein 1

    See identical proteins and their annotated locations for NP_695019.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC117245, AC124662
    Consensus CDS
    CCDS23620.1
    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Conserved Domains (1) summary
    pfam16019
    Location:80303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119800229..119813808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512040.4XP_006512103.1  cysteine/serine-rich nuclear protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006512103.1

    UniProtKB/Swiss-Prot
    P59054, Q3USP7
    Conserved Domains (1) summary
    pfam16019
    Location:80303
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus