U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trmt2b TRM2 tRNA methyltransferase 2B [ Mus musculus (house mouse) ]

Gene ID: 215201, updated on 12-May-2024

Summary

Official Symbol
Trmt2bprovided by MGI
Official Full Name
TRM2 tRNA methyltransferase 2Bprovided by MGI
Primary source
MGI:MGI:2442530
See related
Ensembl:ENSMUSG00000067369 AllianceGenome:MGI:2442530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4732479N06Rik
Summary
Predicted to enable S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity. Predicted to be involved in RNA processing. Predicted to act upstream of or within methylation and tRNA processing. Located in mitochondrion. Is expressed in olfactory cortex ventricular layer and telencephalon ventricular layer. Orthologous to human TRMT2B (tRNA methyltransferase 2 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 10.8), bladder adult (RPKM 6.8) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Trmt2b in Genome Data Viewer
Location:
X E3; X 55.95 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133123704..133177770, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134222955..134277023, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group related, X-linked Neighboring gene STARR-seq mESC enhancer starr_47954 Neighboring gene ADP-ribosylation factor-like 13A Neighboring gene STARR-seq mESC enhancer starr_47955 Neighboring gene transmembrane protein 35A Neighboring gene centromere protein I

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

General gene information

General protein information

Preferred Names
tRNA (uracil-5-)-methyltransferase homolog B
Names
TRM2 homolog
TRM2 homolog B
TRM2 tRNA methyltransferase 2 homolog B
rRNA (uracil-5-)-methyltransferase TRMT2B
tRNA (uracil(54)-C(5))-methyltransferase homolog
tRNA (uracil-5-)-methyltransferase homolog
NP_001161466.1
NP_001161467.1
NP_766128.2
XP_006528577.1
XP_011246036.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167994.1NP_001161466.1  tRNA (uracil-5-)-methyltransferase homolog B isoform a

    See identical proteins and their annotated locations for NP_001161466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK028999, AK046928, BC056937
    Consensus CDS
    CCDS41121.1
    UniProtKB/Swiss-Prot
    Q8BQJ6, Q8CE55
    UniProtKB/TrEMBL
    S4R2E5
    Related
    ENSMUSP00000108878.2, ENSMUST00000113252.8
    Conserved Domains (2) summary
    COG2265
    Location:83486
    TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
    cl17173
    Location:290490
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001167995.1NP_001161467.1  tRNA (uracil-5-)-methyltransferase homolog B isoform b

    See identical proteins and their annotated locations for NP_001161467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI835629, AK046928
    Consensus CDS
    CCDS53183.1
    UniProtKB/TrEMBL
    Q8C8J3
    Related
    ENSMUSP00000084819.4, ENSMUST00000087540.4
  3. NM_172540.2NP_766128.2  tRNA (uracil-5-)-methyltransferase homolog B isoform a

    See identical proteins and their annotated locations for NP_766128.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK028999, AK046928, AK049523
    Consensus CDS
    CCDS41121.1
    UniProtKB/Swiss-Prot
    Q8BQJ6, Q8CE55
    UniProtKB/TrEMBL
    S4R2E5
    Related
    ENSMUSP00000084820.6, ENSMUST00000087541.12
    Conserved Domains (2) summary
    COG2265
    Location:83486
    TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
    cl17173
    Location:290490
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    133123704..133177770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247734.4XP_011246036.1  tRNA (uracil-5-)-methyltransferase homolog B isoform X2

    UniProtKB/TrEMBL
    S4R2E5
    Related
    ENSMUSP00000138612.2, ENSMUST00000128115.8
    Conserved Domains (1) summary
    COG2265
    Location:83418
    TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
  2. XM_006528514.5XP_006528577.1  tRNA (uracil-5-)-methyltransferase homolog B isoform X1

    UniProtKB/TrEMBL
    S4R2E5
    Conserved Domains (1) summary
    COG2265
    Location:83441
    TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]