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Vgll2 vestigial like family member 2 [ Mus musculus (house mouse) ]

Gene ID: 215031, updated on 2-Nov-2024

Summary

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Official Symbol
Vgll2provided by MGI
Official Full Name
vestigial like family member 2provided by MGI
Primary source
MGI:MGI:2447460
See related
Ensembl:ENSMUSG00000049641 AllianceGenome:MGI:2447460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vito1; vgl-2; VITO-1; C130057C21Rik
Summary
This gene is a member of the Vestigial-like (Vgl) gene family and is upregulated during muscle differentiation. The product of this gene interacts with and modifies the DNA-binding properties of the transcription factor, TEF-1, and is important for muscle tissue development. Reduced expression of this gene leads to a reduction in the terminal differentiation of muscle cells. Alternate splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]
Expression
Biased expression in limb E14.5 (RPKM 21.9), mammary gland adult (RPKM 2.2) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Vgll2 in Genome Data Viewer
Location:
10 B3; 10 26.16 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (51898598..51904567)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (52022502..52028471)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26665 Neighboring gene predicted gene, 23906 Neighboring gene STARR-seq mESC enhancer starr_26666 Neighboring gene predicted gene, 40646 Neighboring gene Ros1 proto-oncogene Neighboring gene predicted gene 20630 Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional cofactor Vgll2 is required for functional adaptations of skeletal muscle induced by chronic overload. Honda M, et al. J Cell Physiol, 2019 Sep. PMID 30724341
  2. Vestigial-like 2 contributes to normal muscle fiber type distribution in mice. Honda M, et al. Sci Rep, 2017 Aug 2. PMID 28769032, Free PMC Article
  3. VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. Mielcarek M, et al. Mech Dev, 2002 Dec. PMID 14516696
  4. Transcription cofactor Vgl-2 is required for skeletal muscle differentiation. Chen HH, et al. Genesis, 2004 Aug. PMID 15287000
  5. VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development. Mielcarek M, et al. Gene Expr Patterns, 2009 Mar. PMID 19118645

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that Vgll2 may be both directly and indirectly involved in the programing of slow muscle fibers through the formation of the Vgll2-TEAD complex.
    Title: Vestigial-like 2 contributes to normal muscle fiber type distribution in mice.
  2. VITO-1 is a crucial new cofactor of the muscle regulatory programme; VITO-1, a new scalloped interaction domain-containing protein, binds to TEF1 in vitro and strongly stimulates transcription of a reporter plasmid together with TEF-1
    Title: VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation.
  3. Vestigial like 2 homolog is required for muscle gene expression, in part by switching DNA binding of TEF-1 factors during muscle differentiation.
    Title: Transcription cofactor Vgl-2 is required for skeletal muscle differentiation.
  4. A transcription cofactor required for skeletal muscle differentiation that modifies DNA target selectivity of the Transcriptional Enhancer Factor-1 (TEF-1) transcription factors.
    Title: Transcription cofactor Vgl-2 is required for skeletal muscle differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription cofactor vestigial-like protein 2
Names
vestigial like 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300957.1 → NP_001287886.1  transcription cofactor vestigial-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001287886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC153950, AF542181, AK052987
    Consensus CDS
    CCDS78812.1
    UniProtKB/Swiss-Prot
    Q8BGW8
    UniProtKB/TrEMBL
    A0A0R4J0M3
    Conserved Domains (1) summary
    pfam07545
    Location:78 → 108
    Vg_Tdu; Vestigial/Tondu family

  2. NM_153786.2 → NP_722481.1  transcription cofactor vestigial-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_722481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC153950, AF542181, AK048390
    Consensus CDS
    CCDS23837.1
    UniProtKB/Swiss-Prot
    Q8BGW8, Q8BWB4
    Related
    ENSMUSP00000124091.2, ENSMUST00000163017.10
    Conserved Domains (1) summary
    pfam07545
    Location:78 → 108
    Vg_Tdu; Vestigial/Tondu family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    51898598..51904567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGW8.1 GenPept UniProtKB/Swiss-Prot:Q8BGW8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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