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Mmp21 matrix metallopeptidase 21 [ Mus musculus (house mouse) ]

Gene ID: 214766, updated on 8-Dec-2022

Summary

Official Symbol
Mmp21provided by MGI
Official Full Name
matrix metallopeptidase 21provided by MGI
Primary source
MGI:MGI:2664387
See related
Ensembl:ENSMUSG00000030981 AllianceGenome:MGI:2664387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b2b873Clo; b2b2458Clo
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. Mice harboring certain mutations in this gene exhibit congenital heart defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Mmp21 in Genome Data Viewer
Location:
7; 7 F3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133275999..133281790, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (133674270..133680061, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35625 Neighboring gene erythroid differentiation regulatory factor 1 Neighboring gene uroporphyrinogen III synthase Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 32 Neighboring gene predicted gene 15483

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC124281, MGC124282

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
matrix metalloproteinase-21
NP_001307145.1
NP_694423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320216.1NP_001307145.1  matrix metalloproteinase-21 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC127348, BC106860
    Consensus CDS
    CCDS85442.1
    UniProtKB/TrEMBL
    Q3KP74
    Related
    ENSMUSP00000113853.2, ENSMUST00000122136.2
    Conserved Domains (4) summary
    cd04278
    Location:170326
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:169326
    Peptidase_M10; Matrixin
    pfam01471
    Location:48107
    PG_binding_1; Putative peptidoglycan binding domain
    cl02471
    Location:328412
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
  2. NM_152944.1NP_694423.1  matrix metalloproteinase-21 isoform 1 precursor

    See identical proteins and their annotated locations for NP_694423.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC127348, BC106861
    Consensus CDS
    CCDS21933.1
    UniProtKB/Swiss-Prot
    Q8K3F2
    UniProtKB/TrEMBL
    Q3KP73
    Related
    ENSMUSP00000033278.2, ENSMUST00000033278.8
    Conserved Domains (4) summary
    cd00094
    Location:328544
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:170326
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:169326
    Peptidase_M10; Matrixin
    pfam01471
    Location:48107
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    133275999..133281790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)