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Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box [ Mus musculus (house mouse) ]

Gene ID: 21416, updated on 3-Dec-2016
Official Symbol
Tcf7l2provided by MGI
Official Full Name
transcription factor 7 like 2, T cell specific, HMG boxprovided by MGI
Primary source
MGI:MGI:1202879
See related
Ensembl:ENSMUSG00000024985 Vega:OTTMUSG00000020410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcf4; TCF4B; TCF4E; Tcf-4
Annotation information
Note: Tcf4 (GeneID: 21413) and Tcf7l2 (GeneID: 21416) loci share the Tcf4 symbol/alias in common. Tcf4 is a widely used alternative name for T-cell-specific transcription factor 4 (Tcf7l2) conflicting with the official symbol for transcription factor 4 (Tcf4). [26 Jun 2008]
Orthologs
Location:
19 D2; 19 51.59 cM
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (55741785..55933661)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (55816300..56008145)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene RIKEN cDNA 4930552P12 gene Neighboring gene predicted gene, 41871 Neighboring gene predicted gene, 31734 Neighboring gene predicted gene, 41872 Neighboring gene uncharacterized LOC102634217

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
    Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Acute myeloid leukemia, conserved biosystem (from KEGG)
    Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
    Beta-catenin independent WNT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Ca2+ pathway, organism-specific biosystem (from REACTOME)
    Ca2+ pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Deactivation of the beta-catenin transactivating complex, organism-specific biosystem (from REACTOME)
    Deactivation of the beta-catenin transactivating complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
    Degradation of beta-catenin by the destruction complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Endometrial cancer, organism-specific biosystem (from KEGG)
    Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Endometrial cancer, conserved biosystem (from KEGG)
    Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystem (from REACTOME)
    Formation of the beta-catenin:TCF transactivating complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Prostate cancer, organism-specific biosystem (from KEGG)
    Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • Prostate cancer, conserved biosystem (from KEGG)
    Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • Repression of WNT target genes, organism-specific biosystem (from REACTOME)
    Repression of WNT target genes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Thyroid cancer, organism-specific biosystem (from KEGG)
    Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
  • Thyroid cancer, conserved biosystem (from KEGG)
    Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
  • Wnt signaling, organism-specific biosystem (from KEGG)
    Wnt signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling, conserved biosystem (from KEGG)
    Wnt signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IGI
Inferred from Genetic Interaction
more info
PubMed 
gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
nuclear hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
blood vessel development ISO
Inferred from Sequence Orthology
more info
 
bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
catenin import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digestive tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic genitalia morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic hindgut morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
face morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of DNA repeat elements ISO
Inferred from Sequence Orthology
more info
 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
myoblast fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
myoblast fate commitment ISO
Inferred from Sequence Orthology
more info
 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neural tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
secretory granule localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin development IGI
Inferred from Genetic Interaction
more info
PubMed 
somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
beta-catenin-TCF7L2 complex ISO
Inferred from Sequence Orthology
more info
 
catenin-TCF7L2 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription factor 7-like 2
Names
HMG box transcription factor 4
HMG box transcription factor TCF7L2
T-cell-specific transcription factor 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142918.2NP_001136390.1  transcription factor 7-like 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916, AI451561, AJ223070
    Consensus CDS
    CCDS50471.1
    UniProtKB/TrEMBL
    E9QQ91
    Related
    ENSMUSP00000107283, OTTMUSP00000022196, ENSMUST00000111656, OTTMUST00000048432
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  2. NM_001142919.2NP_001136391.1  transcription factor 7-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC157916, AI451561, AK038720
    Related
    ENSMUSP00000123428, OTTMUSP00000022198, ENSMUST00000127233, OTTMUST00000048434
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  3. NM_001142920.2NP_001136392.1  transcription factor 7-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916, AI451561, AK035059
    Consensus CDS
    CCDS50469.1
    UniProtKB/TrEMBL
    E9Q990
    Related
    ENSMUSP00000107286, OTTMUSP00000022191, ENSMUST00000111658, OTTMUST00000048427
    Conserved Domains (2) summary
    cd01388
    Location:354421
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  4. NM_001142921.2NP_001136393.1  transcription factor 7-like 2 isoform 5

    See identical proteins and their annotated locations for NP_001136393.1

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Consensus CDS
    CCDS50470.1
    UniProtKB/Swiss-Prot
    Q924A0
    UniProtKB/TrEMBL
    A0A0R4J1G0
    Related
    ENSMUSP00000107287, OTTMUSP00000022199, ENSMUST00000111659, OTTMUST00000048435
    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  5. NM_001142922.2NP_001136394.1  transcription factor 7-like 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Consensus CDS
    CCDS50472.1
    UniProtKB/TrEMBL
    E9QQ90
    Related
    ENSMUSP00000107284, ENSMUST00000111657
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  6. NM_001142923.2NP_001136395.1  transcription factor 7-like 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Consensus CDS
    CCDS50473.1
    UniProtKB/TrEMBL
    D3YWT3
    Related
    ENSMUSP00000042950, OTTMUSP00000022202, ENSMUST00000041717, OTTMUST00000048438
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  7. NM_001142924.2NP_001136396.1  transcription factor 7-like 2 isoform 8

    See identical proteins and their annotated locations for NP_001136396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (8) has a substantially shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC118695, AI451561, AK048536, CA750374
    Consensus CDS
    CCDS50474.1
    UniProtKB/Swiss-Prot
    Q924A0
    Related
    ENSMUSP00000107273, OTTMUSP00000022197, ENSMUST00000111646, OTTMUST00000048433
    Conserved Domains (2) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
  8. NM_001331135.1NP_001318064.1  transcription factor 7-like 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  9. NM_001331136.1NP_001318065.1  transcription factor 7-like 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  10. NM_001331137.1NP_001318066.1  transcription factor 7-like 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  11. NM_001331138.1NP_001318067.1  transcription factor 7-like 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  12. NM_001331139.1NP_001318068.1  transcription factor 7-like 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  13. NM_001331140.1NP_001318069.1  transcription factor 7-like 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  14. NM_001331141.1NP_001318070.1  transcription factor 7-like 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  15. NM_001331142.1NP_001318071.1  transcription factor 7-like 2 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  16. NM_001331143.1NP_001318072.1  transcription factor 7-like 2 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  17. NM_001331144.1NP_001318073.1  transcription factor 7-like 2 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  18. NM_001331145.1NP_001318074.1  transcription factor 7-like 2 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  19. NM_001331146.1NP_001318075.1  transcription factor 7-like 2 isoform 20

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) encodes the longest protein (isoform 20).
    Source sequence(s)
    AC118695, AC137148, AC157916
  20. NM_001331147.1NP_001318076.1  transcription factor 7-like 2 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  21. NM_001331148.1NP_001318077.1  transcription factor 7-like 2 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  22. NM_001331149.1NP_001318078.1  transcription factor 7-like 2 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  23. NM_001331150.1NP_001318079.1  transcription factor 7-like 2 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
  24. NM_009333.4NP_033359.2  transcription factor 7-like 2 isoform 3

    See identical proteins and their annotated locations for NP_033359.2

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916
    Consensus CDS
    CCDS29911.1
    UniProtKB/TrEMBL
    F6WBK9
    Related
    ENSMUSP00000050081, ENSMUST00000061496
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding

RNA

  1. NR_138565.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC118695, AC137148, AC157916

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    55741785..55933661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318115.1XP_017173604.1  

  2. XM_017318119.1XP_017173608.1  

  3. XM_017318126.1XP_017173615.1  

  4. XM_017318120.1XP_017173609.1  

    Related
    ENSMUSP00000107281, OTTMUSP00000022201, ENSMUST00000111654, OTTMUST00000048437
  5. XM_017318121.1XP_017173610.1  

  6. XM_017318125.1XP_017173614.1  

  7. XM_017318131.1XP_017173620.1  

  8. XM_006526888.3XP_006526951.1  

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  9. XM_017318122.1XP_017173611.1  

  10. XM_017318129.1XP_017173618.1  

  11. XM_006526861.3XP_006526924.1  

    Conserved Domains (3) summary
    cd01388
    Location:354421
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
    pfam15961
    Location:510601
    DUF4764; Domain of unknown function (DUF4764)
  12. XM_006526863.3XP_006526926.1  

    Conserved Domains (3) summary
    cd01388
    Location:349416
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
    pfam15961
    Location:505596
    DUF4764; Domain of unknown function (DUF4764)
  13. XM_006526866.3XP_006526929.1  

    Conserved Domains (2) summary
    cd01388
    Location:335402
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  14. XM_006526869.3XP_006526932.1  

    Related
    ENSMUSP00000107291, ENSMUST00000111662
    Conserved Domains (2) summary
    cd01388
    Location:330397
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  15. XM_017318127.1XP_017173616.1  

  16. XM_017318112.1XP_017173601.1  

  17. XM_017318123.1XP_017173612.1  

  18. XM_017318128.1XP_017173617.1  

  19. XM_006526867.3XP_006526930.1  

    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  20. XM_006526890.3XP_006526953.1  

    Conserved Domains (2) summary
    cd01388
    Location:326393
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17236
    CTNNB1_binding; N-terminal CTNNB1 binding
  21. XM_017318130.1XP_017173619.1  

  22. XM_017318133.1XP_017173622.1  

  23. XM_017318113.1XP_017173602.1  

  24. XM_017318116.1XP_017173605.1  

  25. XM_006526860.3XP_006526923.1  

    Conserved Domains (3) summary
    cd01388
    Location:358425
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
    pfam15961
    Location:514605
    DUF4764; Domain of unknown function (DUF4764)
  26. XM_017318117.1XP_017173606.1  

  27. XM_017318110.1XP_017173599.1  

  28. XM_017318114.1XP_017173603.1  

    Related
    ENSMUSP00000118661, OTTMUSP00000022195, ENSMUST00000153888, OTTMUST00000048431
  29. XM_017318118.1XP_017173607.1  

  30. XM_006526862.3XP_006526925.1  

    Conserved Domains (3) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
    pfam15961
    Location:509600
    DUF4764; Domain of unknown function (DUF4764)
  31. XM_006526885.3XP_006526948.1  

    Conserved Domains (2) summary
    cd01388
    Location:353420
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:17259
    CTNNB1_binding; N-terminal CTNNB1 binding
  32. XM_017318124.1XP_017173613.1  

  33. XM_017318111.1XP_017173600.1  

  34. XM_017318134.1XP_017173623.1  

    Conserved Domains (2) summary
    cd01388
    Location:69136
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam15961
    Location:225316
    DUF4764; Domain of unknown function (DUF4764)
  35. XM_006526895.3XP_006526958.1  

    See identical proteins and their annotated locations for XP_006526958.1

    Conserved Domains (3) summary
    cd01388
    Location:175242
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
    pfam15961
    Location:331422
    DUF4764; Domain of unknown function (DUF4764)
  36. XM_006526897.3XP_006526960.1  

    Conserved Domains (3) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
    pfam15961
    Location:326417
    DUF4764; Domain of unknown function (DUF4764)
  37. XM_017318135.1XP_017173624.1  

  38. XM_006526894.3XP_006526957.1  

    See identical proteins and their annotated locations for XP_006526957.1

    Conserved Domains (3) summary
    cd01388
    Location:175242
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
    pfam15961
    Location:331422
    DUF4764; Domain of unknown function (DUF4764)
  39. XM_017318132.1XP_017173621.1  

    Conserved Domains (3) summary
    cd01388
    Location:170237
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:276
    CTNNB1_binding; N-terminal CTNNB1 binding
    pfam15961
    Location:326417
    DUF4764; Domain of unknown function (DUF4764)

RNA

  1. XR_001782574.1 RNA Sequence

  2. XR_386455.3 RNA Sequence

  3. XR_001782575.1 RNA Sequence

  4. XR_001782576.1 RNA Sequence

  5. XR_001782572.1 RNA Sequence

  6. XR_001782573.1 RNA Sequence

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