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Tet2 tet methylcytosine dioxygenase 2 [ Mus musculus (house mouse) ]

Gene ID: 214133, updated on 31-Jan-2023

Summary

Official Symbol
Tet2provided by MGI
Official Full Name
tet methylcytosine dioxygenase 2provided by MGI
Primary source
MGI:MGI:2443298
See related
Ensembl:ENSMUSG00000040943 AllianceGenome:MGI:2443298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ayu17-449; mKIAA1546; E130014J05Rik
Summary
Enables methylcytosine dioxygenase activity. Involved in cellular protein modification process; myeloid cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including DNA demethylation; animal organ development; and hematopoietic stem cell homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; lower urogenital tract; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 4.9), CNS E11.5 (RPKM 4.5) and 28 other tissues See more
Orthologs
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Genomic context

See Tet2 in Genome Data Viewer
Location:
3; 3 G3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (133169438..133250882, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (133463677..133545136, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor (GEF) 38 Neighboring gene predicted gene, 52616 Neighboring gene pyrophosphatase (inorganic) 2 Neighboring gene predicted gene 49316 Neighboring gene predicted gene, 23011

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC37385

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylcytosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylcytosine dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methylcytosine dioxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables methylcytosine dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 5-methylcytosine catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within 5-methylcytosine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within DNA demethylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA demethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA demethylation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cytosine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemoglobin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
methylcytosine dioxygenase TET2
Names
probable methylcytosine dioxygenase TET2
tet oncogene 2
tet oncogene family member 2
NP_001035490.2
NP_001333665.1
XP_006501346.1
XP_006501349.1
XP_006501350.1
XP_011238370.1
XP_036018905.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040400.2NP_001035490.2  methylcytosine dioxygenase TET2 isoform 1

    See identical proteins and their annotated locations for NP_001035490.2

    Status: VALIDATED

    Source sequence(s)
    AK129389, AK153311, BE137977, BF463367, DQ079067
    Consensus CDS
    CCDS51071.1
    UniProtKB/Swiss-Prot
    Q4JK59, Q8K2K3
    Related
    ENSMUSP00000096203.4, ENSMUST00000098603.8
    Conserved Domains (1) summary
    pfam12851
    Location:12031340
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
  2. NM_001346736.1NP_001333665.1  methylcytosine dioxygenase TET2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120398, BF463367, DQ079067
    Consensus CDS
    CCDS84675.1
    UniProtKB/Swiss-Prot
    Q4JK59
    UniProtKB/TrEMBL
    A0A0G2JF55
    Related
    ENSMUSP00000143029.2, ENSMUST00000196398.5
    Conserved Domains (1) summary
    cl40427
    Location:10481373
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    133169438..133250882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501283.5XP_006501346.1  methylcytosine dioxygenase TET2 isoform X1

    See identical proteins and their annotated locations for XP_006501346.1

    UniProtKB/TrEMBL
    A0A0G2JF55
    Conserved Domains (1) summary
    cl40427
    Location:10481373
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
  2. XM_006501287.5XP_006501350.1  methylcytosine dioxygenase TET2 isoform X3

    Conserved Domains (1) summary
    cl40427
    Location:10481364
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
  3. XM_006501286.5XP_006501349.1  methylcytosine dioxygenase TET2 isoform X2

    Conserved Domains (1) summary
    cl40427
    Location:10481372
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
  4. XM_011240068.4XP_011238370.1  methylcytosine dioxygenase TET2 isoform X1

    See identical proteins and their annotated locations for XP_011238370.1

    UniProtKB/TrEMBL
    A0A0G2JF55
    Conserved Domains (1) summary
    cl40427
    Location:10481373
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
  5. XM_036163012.1XP_036018905.1  methylcytosine dioxygenase TET2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JF55
    Conserved Domains (1) summary
    cl40427
    Location:10481373
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145989.1: Suppressed sequence

    Description
    NM_145989.1: This RefSeq was permanently suppressed based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.