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Tbx2 T-box 2 [ Mus musculus (house mouse) ]

Gene ID: 21385, updated on 24-Jan-2023

Summary

Official Symbol
Tbx2provided by MGI
Official Full Name
T-box 2provided by MGI
Primary source
MGI:MGI:98494
See related
Ensembl:ENSMUSG00000000093 AllianceGenome:MGI:98494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including circulatory system development; embryonic morphogenesis; and negative regulation of heart looping. Acts upstream of or within several processes, including animal organ development; muscle cell fate determination; and ureteric peristalsis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 133.6), bladder adult (RPKM 53.9) and 11 other tissues See more
Orthologs
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Genomic context

See Tbx2 in Genome Data Viewer
Location:
11 C; 11 51.34 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (85723441..85732774)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (85832615..85841948)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene BCAS3 microtubule associated cell migration factor Neighboring gene RIKEN cDNA 2610027K06 gene Neighboring gene BCAS3 microtubule associated cell migration factor, opposite strand 2 Neighboring gene Tbx2 5' regulatory region Neighboring gene VISTA enhancer mm1583 Neighboring gene HLEA enhancer upstream of Tbx4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular canal development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in atrioventricular canal development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular canal morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac jelly development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within developmental growth involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
 
involved_in endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial tube branching involved in lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary placode formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in melanocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesenchymal cell proliferation involved in lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac chamber formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pharynx development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_negative_effect pigment metabolic process involved in pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smooth muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ureteric peristalsis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
T-box transcription factor TBX2
Names
T-box protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009324.2NP_033350.2  T-box transcription factor TBX2

    See identical proteins and their annotated locations for NP_033350.2

    Status: VALIDATED

    Source sequence(s)
    AI256645, AK149348, CJ045432, CJ307790
    Consensus CDS
    CCDS36266.1
    UniProtKB/Swiss-Prot
    Q5SSP7, Q60707
    UniProtKB/TrEMBL
    Q3UET7
    Related
    ENSMUSP00000000095.7, ENSMUST00000000095.7
    Conserved Domains (2) summary
    pfam12598
    Location:305382
    TBX; T-box transcription factor
    cd00182
    Location:104289
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    85723441..85732774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)