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Tbx15 T-box 15 [ Mus musculus (house mouse) ]

Gene ID: 21384, updated on 9-May-2024

Summary

Official Symbol
Tbx15provided by MGI
Official Full Name
T-box 15provided by MGI
Primary source
MGI:MGI:1277234
See related
Ensembl:ENSMUSG00000027868 AllianceGenome:MGI:1277234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
de; Tbx8; Tbx14; mmTBx8
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic cranial skeleton morphogenesis. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including branchial arch; embryo mesenchyme; facial prominence; genitourinary system; and limb. Orthologous to human TBX15 (T-box transcription factor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 21.8), mammary gland adult (RPKM 8.5) and 2 other tissues See more
Orthologs
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Genomic context

See Tbx15 in Genome Data Viewer
Location:
3 F2.2; 3 43.03 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (99147671..99261576)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (99240348..99354260)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene tryptophanyl tRNA synthetase 2 (mitochondrial) Neighboring gene microRNA 6481 Neighboring gene predicted gene, 38468 Neighboring gene VISTA enhancer mm888 Neighboring gene predicted gene, 46817 Neighboring gene STARR-seq mESC enhancer starr_08485 Neighboring gene predicted gene, 52611 Neighboring gene predicted gene, 54211 Neighboring gene cytochrome b-c1 complex subunit 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-box transcription factor TBX15
Names
T-box 14
T-box protein 14
T-box protein 15
T-box transcription factor TBX14
droopy ear

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410561.1NP_001397490.1  T-box transcription factor TBX15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC080018, AL606745, AL606747
  2. NM_001410562.1NP_001397491.1  T-box transcription factor TBX15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606745, AL606747
  3. NM_009323.3NP_033349.2  T-box transcription factor TBX15 isoform 1

    See identical proteins and their annotated locations for NP_033349.2

    Status: VALIDATED

    Source sequence(s)
    AC080018, AL606745, AL606747
    Consensus CDS
    CCDS17673.1
    UniProtKB/Swiss-Prot
    O54840, O70306, Q5GBG1
    Related
    ENSMUSP00000029462.6, ENSMUST00000029462.10
    Conserved Domains (1) summary
    cd00182
    Location:113308
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    99147671..99261576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501279.5XP_006501342.1  T-box transcription factor TBX15 isoform X1

    See identical proteins and their annotated locations for XP_006501342.1

    Conserved Domains (1) summary
    cd20198
    Location:1198
    T-box_TBX15-like; DNA-binding domain of T-box transcription factor 15 and related T-box proteins