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Cracr2b calcium release activated channel regulator 2B [ Mus musculus (house mouse) ]

Gene ID: 213573, updated on 2-Nov-2024

Summary

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Official Symbol
Cracr2bprovided by MGI
Official Full Name
calcium release activated channel regulator 2Bprovided by MGI
Primary source
MGI:MGI:2446129
See related
Ensembl:ENSMUSG00000048200 AllianceGenome:MGI:2446129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Efcab4; Cracr2a; Efcab4a; 6330520A15Rik
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in store-operated calcium entry. Orthologous to human CRACR2B (calcium release activated channel regulator 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 35.7), colon adult (RPKM 21.5) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Cracr2b in Genome Data Viewer
Location:
7 F5; 7 86.82 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141041007..141046526)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141460875..141466613)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene STARR-positive B cell enhancer ABC_E9305 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene predicted gene 10575 Neighboring gene CD151 antigen Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cracking CRAC. Carrasco S, et al. Nat Cell Biol, 2010 May. PMID 20442700, Free PMC Article
  2. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Srikanth S, et al. Nat Cell Biol, 2010 May. PMID 20418871, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
  
involved_in store-operated calcium entry ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 4A
Names
EF-hand calcium binding domain 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025103.2 → NP_001020274.2  EF-hand calcium-binding domain-containing protein 4A

    See identical proteins and their annotated locations for NP_001020274.2

    Status: VALIDATED

    Source sequence(s)
    BC048916
    Consensus CDS
    CCDS22016.1
    UniProtKB/Swiss-Prot
    Q4KMV3, Q80ZJ8, Q8R0L0
    Related
    ENSMUSP00000055899.6, ENSMUST00000053670.12
    Conserved Domains (2) summary
    PRK12309
    Location:26 → 92
    PRK12309; transaldolase
    TIGR02168
    Location:168 → 322
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141041007..141046526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536174.3 → XP_006536237.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

    See identical proteins and their annotated locations for XP_006536237.1

    UniProtKB/Swiss-Prot
    Q4KMV3, Q80ZJ8, Q8R0L0
    Conserved Domains (2) summary
    PRK12309
    Location:26 → 92
    PRK12309; transaldolase
    TIGR02168
    Location:168 → 322
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_036152881.1 → XP_036008774.1  EF-hand calcium-binding domain-containing protein 4A isoform X2

    Conserved Domains (2) summary
    PRK12309
    Location:26 → 92
    PRK12309; transaldolase
    COG1196
    Location:158 → 336
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_036152880.1 → XP_036008773.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

    UniProtKB/Swiss-Prot
    Q4KMV3, Q80ZJ8, Q8R0L0
    Conserved Domains (2) summary
    PRK12309
    Location:26 → 92
    PRK12309; transaldolase
    TIGR02168
    Location:168 → 322
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZJ8.2 GenPept UniProtKB/Swiss-Prot:Q80ZJ8

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