Cracr2b calcium release activated channel regulator 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cracr2bprovided by MGI
Official Full Name: calcium release activated channel regulator 2Bprovided by MGI
Primary source: MGI:MGI:2446129
See related: Ensembl:ENSMUSG00000048200 AllianceGenome:MGI:2446129
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Efcab4; Cracr2a; Efcab4a; 6330520A15Rik
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within regulation of store-operated calcium entry. Located in cytoplasm. Orthologous to human CRACR2B (calcium release activated channel regulator 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 35.7), colon adult (RPKM 21.5) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 F5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (141041007..141046526)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141460875..141466613)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Homology

Homologs of the Cracr2b gene: The Cracr2b gene is conserved in human, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 457 organisms have orthologs with human gene Cracr2b

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of store-operated calcium entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in store-operated calcium entry	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: EF-hand calcium-binding domain-containing protein 4A

Names: EF-hand calcium binding domain 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025103.2 → NP_001020274.2 EF-hand calcium-binding domain-containing protein 4A

See identical proteins and their annotated locations for NP_001020274.2

Status: VALIDATED

Source sequence(s)

BC048916

Consensus CDS

CCDS22016.1

UniProtKB/Swiss-Prot

Q80ZJ8, Q8R0L0

Related

ENSMUSP00000055899.6, ENSMUST00000053670.12

Conserved Domains (2) summary

PRK12309
Location:26 → 92

PRK12309; transaldolase

TIGR02168
Location:168 → 322

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

141041007..141046526

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006536174.3 → XP_006536237.1 EF-hand calcium-binding domain-containing protein 4A isoform X1

See identical proteins and their annotated locations for XP_006536237.1

UniProtKB/Swiss-Prot

Q80ZJ8, Q8R0L0

Conserved Domains (2) summary

PRK12309
Location:26 → 92

PRK12309; transaldolase

TIGR02168
Location:168 → 322

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_036152881.1 → XP_036008774.1 EF-hand calcium-binding domain-containing protein 4A isoform X2

Conserved Domains (2) summary

PRK12309
Location:26 → 92

PRK12309; transaldolase

COG1196
Location:158 → 336

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
XM_036152880.1 → XP_036008773.1 EF-hand calcium-binding domain-containing protein 4A isoform X1

UniProtKB/Swiss-Prot

Q8R0L0

Conserved Domains (2) summary

PRK12309
Location:26 → 92

PRK12309; transaldolase

TIGR02168
Location:168 → 322

SMC_prok_B; chromosome segregation protein SMC, common bacterial type