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Lacc1 laccase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 210808, updated on 18-Sep-2024

Summary

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Official Symbol
Lacc1provided by MGI
Official Full Name
laccase domain containing 1provided by MGI
Primary source
MGI:MGI:2445077
See related
Ensembl:ENSMUSG00000044350 AllianceGenome:MGI:2445077
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030625A04Rik
Summary
Predicted to enable adenosine deaminase activity; copper ion binding activity; and pentosyltransferase activity. Involved in regulation of inflammatory response and regulation of purine nucleotide metabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis. Orthologous to human LACC1 (laccase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.9), liver E18 (RPKM 5.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lacc1 in Genome Data Viewer
Location:
14 D3; 14 40.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (77261640..77274344, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77021739..77036929, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37199 Neighboring gene STARR-seq mESC enhancer starr_37200 Neighboring gene predicted gene, 30365 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77411648-77411949 Neighboring gene STARR-seq mESC enhancer starr_37202 Neighboring gene STARR-seq mESC enhancer starr_37203 Neighboring gene STARR-positive B cell enhancer ABC_E5459 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_37204 Neighboring gene coiled-coil domain containing 122 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77541449-77541750 Neighboring gene STARR-seq mESC enhancer starr_37206 Neighboring gene ecto-NOX disulfide-thiol exchanger 1 Neighboring gene STARR-seq mESC enhancer starr_37207 Neighboring gene STARR-seq mESC enhancer starr_37208 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene predicted gene, 41217

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A purine metabolic checkpoint that prevents autoimmunity and autoinflammation. Saveljeva S, et al. Cell Metab, 2022 Jan 4. PMID 34986329, Free PMC Article
  2. Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation. Kang JW, et al. Gastroenterology, 2020 Sep. PMID 32693188, Free PMC Article
  3. LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation. Skon-Hegg C, et al. J Immunol, 2019 Jan 1. PMID 30510070, Free PMC Article
  4. LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages. Wei Z, et al. Nature, 2022 Sep. PMID 35978195, Free PMC Article
  5. C13orf31 (FAMIN) is a central regulator of immunometabolic function. Cader MZ, et al. Nat Immunol, 2016 Sep. PMID 27478939, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction.
    Title: LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction.
  2. LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease.
    Title: LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease.
  3. LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.
    Title: LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.
  4. Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation.
    Title: Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation.
  5. this study shows that LACC1 regulates TNF and IL-17 in mouse models of arthritis and inflammation
    Title: LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation.
  6. this study shows that Lacc1 is a central regulator of the metabolic function and bioenergetic state of macrophages that is under evolutionary selection and determines the risk of inflammatory and infectious disease
    Title: C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2'-deoxyadenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-methyl-5-thioadenosine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables S-methyl-5-thioadenosine phosphorylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables adenosine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables adenosine deaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanosine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables guanosine phosphorylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
enables purine-nucleoside phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables purine-nucleoside phosphorylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in pattern recognition receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytokine production involved in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular pH ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular pH ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of purine nucleotide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
purine nucleoside phosphorylase LACC1
Names
S-methyl-5'-thioadenosine phosphorylase LACC1
adenosine deaminase LACC1
fatty acid metabolism-immunity nexus
guanosine phosphorylase LACC1
laccase (multicopper oxidoreductase) domain containing 1
laccase domain-containing protein 1
NP_766076.1
XP_030103569.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172488.2 → NP_766076.1  purine nucleoside phosphorylase LACC1

    See identical proteins and their annotated locations for NP_766076.1

    Status: PROVISIONAL

    Source sequence(s)
    AK033565
    Consensus CDS
    CCDS27287.1
    UniProtKB/Swiss-Prot
    Q14AQ3, Q3U600, Q8BZT9
    Related
    ENSMUSP00000059173.9, ENSMUST00000062789.15
    Conserved Domains (1) summary
    pfam02578
    Location:218 → 426
    Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    77261640..77274344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247709.2 → XP_030103569.1  purine nucleoside phosphorylase LACC1 isoform X1

    Conserved Domains (1) summary
    pfam02578
    Location:5 → 170
    Cu-oxidase_4; Multi-copper polyphenol oxidoreductase laccase

RNA

  1. XR_003950831.2 RNA Sequence

  2. XR_383153.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZT9.1 GenPept UniProtKB/Swiss-Prot:Q8BZT9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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