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ESRRG estrogen related receptor gamma [ Homo sapiens (human) ]

Gene ID: 2104, updated on 8-Jul-2018
Official Symbol
ESRRGprovided by HGNC
Official Full Name
estrogen related receptor gammaprovided by HGNC
Primary source
HGNC:HGNC:3474
See related
Ensembl:ENSG00000196482 MIM:602969; Vega:OTTHUMG00000037025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERR3; ERRg; NR3B3; ERRgamma; ERR-gamma
Summary
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Expression
Biased expression in kidney (RPKM 4.4), stomach (RPKM 3.1) and 12 other tissues See more
Orthologs
See ESRRG in Genome Data Viewer
Location:
1q41
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (216503246..217137755, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (216676588..217311097, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene usherin Neighboring gene uncharacterized LOC105372918 Neighboring gene mitochondrial ribosomal protein S18B pseudogene 1 Neighboring gene uncharacterized LOC107985596 Neighboring gene uncharacterized LOC107985461 Neighboring gene uncharacterized LOC105372920

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
NHGRI GWA Catalog
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
NHGRI GWA Catalog
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
NHGRI GWA Catalog
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
NHGRI GWA Catalog
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
    Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16023, KIAA0832, DKFZp781L1617

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
estrogen-related receptor gamma
Names
ERR gamma-2
estrogen receptor-related protein 3
nuclear receptor subfamily 3 group B member 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029784.1 RefSeqGene

    Range
    5001..639510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134285.2NP_001127757.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001127757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BU752915, BX647076
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Related
    ENSP00000355907.2, OTTHUMP00000035095, ENST00000366940.6, OTTHUMT00000089921
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  2. NM_001243505.1NP_001230434.1  estrogen-related receptor gamma isoform 3

    See identical proteins and their annotated locations for NP_001230434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three exons from the 5' end but has alternate three 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020639, BM723962, BU752915
    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (1) summary
    cd06946
    Location:1205
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
  3. NM_001243506.1NP_001230435.1  estrogen-related receptor gamma isoform 4

    See identical proteins and their annotated locations for NP_001230435.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two exons from the 5' end but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AB020639, AK298851, BP349857, BU752915
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    B7Z5E9
    Conserved Domains (2) summary
    cd06946
    Location:52271
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cl02596
    Location:133
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  4. NM_001243507.1NP_001230436.1  estrogen-related receptor gamma isoform 5

    See identical proteins and their annotated locations for NP_001230436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks a 5' exon and an internal in-frame exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (5, also known as ERRgamma3) is shorter at the N-terminus and lacks an internal segment corresponding to the second zinc finger motif of the DNA binding domain (PMID:16460929), compared to isoform 1.
    Source sequence(s)
    AB020639, AB362218, AK131193, BU752915, DB220304
    Consensus CDS
    CCDS58060.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    C0SQ93
    Related
    ENSP00000418629.1, OTTHUMP00000216806, ENST00000463665.5, OTTHUMT00000357845
    Conserved Domains (2) summary
    cd06946
    Location:175394
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cl02596
    Location:99156
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  5. NM_001243509.1NP_001230438.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230438.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AB362218, BU752915, DB220304
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000417374.1, OTTHUMP00000216807, ENST00000493748.5, OTTHUMT00000357846
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  6. NM_001243510.2NP_001230439.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230439.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AY388457, BU752915, BX647076, DA293919
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Related
    ENSP00000419594.1, OTTHUMP00000216805, ENST00000493603.5, OTTHUMT00000357844
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  7. NM_001243511.2NP_001230440.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AY388460, BU752915, BX647076, DA293919
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  8. NM_001243512.1NP_001230441.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks the 5' exon but has more than three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AB362218, AK131193, AY388458, BU752915
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000419155.1, OTTHUMP00000216808, ENST00000487276.5, OTTHUMT00000357847
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  9. NM_001243513.1NP_001230442.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230442.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) lacks the 5' exon but has more than two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AB362218, AY388459, BU752915
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    C0SQ93, F1D8R6
    Related
    ENSP00000355905.2, OTTHUMP00000035116, ENST00000366938.6, OTTHUMT00000089960
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  10. NM_001243514.1NP_001230443.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230443.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks the 5' exon but has an alternate 5' exon and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AC096635, AY388461, BU752915
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Related
    ENSP00000353108.3, OTTHUMP00000035126, ENST00000360012.7, OTTHUMT00000089974
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  11. NM_001243515.1NP_001230444.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230444.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) has two additional exons in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AK290945, BU752915, DA720944, DA722064
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  12. NM_001243518.1NP_001230447.1  estrogen-related receptor gamma isoform 6

    See identical proteins and their annotated locations for NP_001230447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) has an additional exon in the 5' region, which includes an AUG start codon, and an additional segment in the middle region, compared to variant 1. The resulting isoform (6) has a longer and distinct N-terminus and an additional internal segment, compared to isoform 1.
    Source sequence(s)
    AB020639, BC064700, BU752915, DA720944
    Consensus CDS
    CCDS58061.1
    UniProtKB/Swiss-Prot
    P62508
    Related
    ENSP00000355904.1, OTTHUMP00000035075, ENST00000366937.5, OTTHUMT00000089881
    Conserved Domains (2) summary
    cd06946
    Location:249468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:127223
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  13. NM_001243519.1NP_001230448.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) has an additional segment in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BC008218, BU752915, DA720944
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Related
    ENSP00000375761.4, ENST00000391890.7
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  14. NM_001350122.1NP_001337051.1  estrogen-related receptor gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AL603752, BU752915, CA397450, DA215341, DA293919, DB220304
    Consensus CDS
    CCDS1517.1
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  15. NM_001350123.1NP_001337052.1  estrogen-related receptor gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BP349857, BU752915, CA397450, DB220304
    Consensus CDS
    CCDS1517.1
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  16. NM_001350124.1NP_001337053.1  estrogen-related receptor gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AL603752, BU752915, BX647076, CA397450, DA215341
    Consensus CDS
    CCDS1517.1
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  17. NM_001350125.1NP_001337054.1  estrogen-related receptor gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BU752915, CA397450, DA096417, DB220304
    Consensus CDS
    CCDS1517.1
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  18. NM_001438.3NP_001429.2  estrogen-related receptor gamma isoform 1

    See identical proteins and their annotated locations for NP_001429.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB020639, BU752915, DA720944
    Consensus CDS
    CCDS41468.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R5
    Related
    ENSP00000386171.3, OTTHUMP00000035076, ENST00000408911.7, OTTHUMT00000089882
    Conserved Domains (2) summary
    cd06946
    Location:237456
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:122218
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  19. NM_206594.2NP_996317.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_996317.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, BP349857, BU752915, CA397450
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Related
    ENSP00000355225.3, ENST00000361525.7
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  20. NM_206595.2NP_996318.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_996318.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' exon but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
    Source sequence(s)
    AB020639, AK291028, BP349857, BU752915
    Consensus CDS
    CCDS1517.1
    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Related
    ENSP00000352077.2, OTTHUMP00000035092, ENST00000359162.6, OTTHUMT00000089913
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    216503246..217137755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000625.1XP_016856114.1  estrogen-related receptor gamma isoform X1

    Conserved Domains (2) summary
    cd06946
    Location:256475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  2. XM_017000639.1XP_016856128.1  estrogen-related receptor gamma isoform X8

    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  3. XM_017000633.1XP_016856122.1  estrogen-related receptor gamma isoform X7

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  4. XM_024453980.1XP_024309748.1  estrogen-related receptor gamma isoform X8

    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  5. XM_017000622.1XP_016856111.1  estrogen-related receptor gamma isoform X1

    Conserved Domains (2) summary
    cd06946
    Location:256475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  6. XM_011509277.1XP_011507579.1  estrogen-related receptor gamma isoform X7

    See identical proteins and their annotated locations for XP_011507579.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  7. XM_017000644.1XP_016856133.1  estrogen-related receptor gamma isoform X8

    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  8. XM_011509275.1XP_011507577.1  estrogen-related receptor gamma isoform X7

    See identical proteins and their annotated locations for XP_011507577.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  9. XM_024453960.1XP_024309728.1  estrogen-related receptor gamma isoform X7

  10. XM_017000624.2XP_016856113.1  estrogen-related receptor gamma isoform X1

    Conserved Domains (2) summary
    cd06946
    Location:256475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  11. XM_011509265.3XP_011507567.1  estrogen-related receptor gamma isoform X1

    Conserved Domains (2) summary
    cd06946
    Location:256475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  12. XM_017000621.2XP_016856110.1  estrogen-related receptor gamma isoform X1

    Conserved Domains (2) summary
    cd06946
    Location:256475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  13. XM_024453979.1XP_024309747.1  estrogen-related receptor gamma isoform X8

    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  14. XM_017000637.1XP_016856126.1  estrogen-related receptor gamma isoform X7

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  15. XM_017000645.1XP_016856134.1  estrogen-related receptor gamma isoform X8

    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  16. XM_011509278.1XP_011507580.1  estrogen-related receptor gamma isoform X7

    See identical proteins and their annotated locations for XP_011507580.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  17. XM_011509274.1XP_011507576.1  estrogen-related receptor gamma isoform X7

    See identical proteins and their annotated locations for XP_011507576.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  18. XM_017000634.2XP_016856123.1  estrogen-related receptor gamma isoform X7

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  19. XM_017000632.2XP_016856121.1  estrogen-related receptor gamma isoform X7

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  20. XM_024453959.1XP_024309727.1  estrogen-related receptor gamma isoform X7

  21. XM_017000631.2XP_016856120.1  estrogen-related receptor gamma isoform X7

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  22. XM_011509266.3XP_011507568.1  estrogen-related receptor gamma isoform X2

    Conserved Domains (2) summary
    cd06946
    Location:249468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  23. XM_024453975.1XP_024309743.1  estrogen-related receptor gamma isoform X8

    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  24. XM_017000638.2XP_016856127.1  estrogen-related receptor gamma isoform X8

    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  25. XM_017000636.2XP_016856125.1  estrogen-related receptor gamma isoform X7

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  26. XM_017000623.2XP_016856112.1  estrogen-related receptor gamma isoform X1

    Conserved Domains (2) summary
    cd06946
    Location:256475
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:134230
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  27. XM_011509268.2XP_011507570.1  estrogen-related receptor gamma isoform X3

    See identical proteins and their annotated locations for XP_011507570.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:249468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:127223
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  28. XM_011509271.2XP_011507573.1  estrogen-related receptor gamma isoform X6

    See identical proteins and their annotated locations for XP_011507573.1

    Conserved Domains (2) summary
    cd06946
    Location:226445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:104200
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  29. XM_011509280.2XP_011507582.1  estrogen-related receptor gamma isoform X7

    See identical proteins and their annotated locations for XP_011507582.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  30. XM_017000627.1XP_016856116.1  estrogen-related receptor gamma isoform X4

  31. XM_011509276.1XP_011507578.1  estrogen-related receptor gamma isoform X7

    See identical proteins and their annotated locations for XP_011507578.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  32. XM_017000641.1XP_016856130.1  estrogen-related receptor gamma isoform X8

    UniProtKB/Swiss-Prot
    P62508
    UniProtKB/TrEMBL
    F1D8R6
    Conserved Domains (2) summary
    cd06946
    Location:214433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  33. XM_011509279.1XP_011507581.1  estrogen-related receptor gamma isoform X7

    See identical proteins and their annotated locations for XP_011507581.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  34. XM_011509267.1XP_011507569.1  estrogen-related receptor gamma isoform X3

    See identical proteins and their annotated locations for XP_011507569.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:249468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:127223
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  35. XM_017000630.1XP_016856119.1  estrogen-related receptor gamma isoform X6

    Conserved Domains (2) summary
    cd06946
    Location:226445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:104200
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  36. XM_017000635.1XP_016856124.1  estrogen-related receptor gamma isoform X7

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:221440
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  37. XM_017000628.1XP_016856117.1  estrogen-related receptor gamma isoform X5

    Conserved Domains (2) summary
    cd06946
    Location:240459
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:118214
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  38. XM_011509269.2XP_011507571.1  estrogen-related receptor gamma isoform X3

    See identical proteins and their annotated locations for XP_011507571.1

    UniProtKB/Swiss-Prot
    P62508
    Conserved Domains (2) summary
    cd06946
    Location:249468
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:127223
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
  39. XM_017000626.1XP_016856115.1  estrogen-related receptor gamma isoform X4

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