U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tent4a terminal nucleotidyltransferase 4A [ Mus musculus (house mouse) ]

Gene ID: 210106, updated on 5-Mar-2024

Summary

Official Symbol
Tent4aprovided by MGI
Official Full Name
terminal nucleotidyltransferase 4Aprovided by MGI
Primary source
MGI:MGI:2682295
See related
Ensembl:ENSMUSG00000034575 AllianceGenome:MGI:2682295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POLK; Pols; TRF4; LAK-1; Papd7; TRF4-1
Summary
Predicted to enable guanylyltransferase activity and polynucleotide adenylyltransferase activity. Predicted to be involved in RNA 3' uridylation; regulation of mRNA stability; and response to xenobiotic stimulus. Predicted to act upstream of or within mRNA processing. Predicted to be located in Golgi apparatus; nuclear membrane; and nucleoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and musculoskeletal system. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 10.5), adrenal adult (RPKM 9.3) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tent4a in Genome Data Viewer
Location:
13 B3; 13 35.55 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (69646071..69682710, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (69497952..69534236, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35444 Neighboring gene STARR-seq mESC enhancer starr_34935 Neighboring gene predicted gene, 35514 Neighboring gene STARR-seq mESC enhancer starr_34936 Neighboring gene STARR-seq mESC enhancer starr_34937 Neighboring gene RIKEN cDNA A930018O16 gene Neighboring gene RIKEN cDNA A530095I07 gene Neighboring gene RAB geranylgeranyl transferase, b subunit pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC69673

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables guanylyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA 3' uridylation ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
terminal nucleotidyltransferase 4A
Names
DNA polymerase sigma
PAP associated domain containing 7
PAP-associated domain-containing protein 7
TRAMP-like complex polyadenylate polymerase
non-canonical poly(A) RNA polymerase PAPD7
polymerase (DNA directed) sigma
terminal guanylyltransferase
NP_001162602.2
NP_941002.3
XP_006517250.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169131.2NP_001162602.2  terminal nucleotidyltransferase 4A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC122484
  2. NM_198600.3NP_941002.3  terminal nucleotidyltransferase 4A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC122484
    Consensus CDS
    CCDS26622.1
    UniProtKB/TrEMBL
    A0A0G2JDV2
    Related
    ENSMUSP00000142516.2, ENSMUST00000198607.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    69646071..69682710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517187.2XP_006517250.1  terminal nucleotidyltransferase 4A isoform X1

    Conserved Domains (1) summary
    COG5260
    Location:233538
    TRF4; DNA polymerase sigma [Replication, recombination and repair]