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Syt1 synaptotagmin I [ Mus musculus (house mouse) ]

Gene ID: 20979, updated on 12-Jun-2018
Official Symbol
Syt1provided by MGI
Official Full Name
synaptotagmin Iprovided by MGI
Primary source
MGI:MGI:99667
See related
Ensembl:ENSMUSG00000035864 Vega:OTTMUSG00000016266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SytI; AW124717; G630098F17Rik
Expression
Biased expression in cortex adult (RPKM 49.2), frontal lobe adult (RPKM 47.7) and 4 other tissues See more
Orthologs
See Syt1 in Genome Data Viewer
Location:
10 D1; 10 56.52 cM
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (108497650..109010978, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (107935305..108447675, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105245279 Neighboring gene predicted gene, 40755 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440 Neighboring gene predicted gene 5136 Neighboring gene predicted gene, 40757 Neighboring gene neuron navigator 3

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
syntaxin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
syntaxin-3 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
fast, calcium ion-dependent exocytosis of neurotransmitter IDA
Inferred from Direct Assay
more info
PubMed 
fast, calcium ion-dependent exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of regulated secretory pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle docking ISO
Inferred from Sequence Orthology
more info
 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with SNARE complex ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
dense core granule IDA
Inferred from Direct Assay
more info
PubMed 
dense core granule ISO
Inferred from Sequence Orthology
more info
 
excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252341.1NP_001239270.1  synaptotagmin-1 isoform 1

    See identical proteins and their annotated locations for NP_001239270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI842617, AK078790, BC042519, BY268027, CD774438
    Consensus CDS
    CCDS24163.1
    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1
    Related
    ENSMUSP00000100912.1, OTTMUSP00000017428, ENSMUST00000105276.7, OTTMUST00000039005
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  2. NM_001252342.1NP_001239271.1  synaptotagmin-1 isoform 2

    See identical proteins and their annotated locations for NP_001239271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses a difference splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI842617, AK018163, AK133578, BC042519, BY268027, CD774438
    UniProtKB/Swiss-Prot
    P46096
    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  3. NM_001358501.1NP_001345430.1  synaptotagmin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI842617, AK018163, AK133578, BC042519, BY259903, CD774438
    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  4. NM_001358502.1NP_001345431.1  synaptotagmin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122472, AI842617, AK018163, BC042519, BY259903, CD774438, EL605393
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  5. NM_001358503.1NP_001345432.1  synaptotagmin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AI842617, AK018163, BC042519, BY259903, CD774438, EL605393
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  6. NM_001358504.1NP_001345433.1  synaptotagmin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI842617, AK018163, AK133578, BB624461, BC042519, BY259903, BY268027, CD774438
    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  7. NM_001358506.1NP_001345435.1  synaptotagmin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI842617, AK018163, AK133578, BB624461, BC042519, BY259903, CD774438
    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  8. NM_009306.3NP_033332.1  synaptotagmin-1 isoform 1

    See identical proteins and their annotated locations for NP_033332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AI842617, BC042519, BY238701, BY268027, CD774438
    Consensus CDS
    CCDS24163.1
    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1
    Related
    ENSMUSP00000063293.7, OTTMUSP00000021532, ENSMUST00000064054.13, OTTMUST00000047565
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

    Range
    108497650..109010978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313867.1XP_017169356.1  synaptotagmin-1 isoform X2

    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  2. XM_006513449.1XP_006513512.1  synaptotagmin-1 isoform X2

    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  3. XM_006513446.1XP_006513509.1  synaptotagmin-1 isoform X1

    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  4. XM_017313868.1XP_017169357.1  synaptotagmin-1 isoform X2

    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  5. XM_017313866.1XP_017169355.1  synaptotagmin-1 isoform X1

    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  6. XM_006513448.1XP_006513511.1  synaptotagmin-1 isoform X1

    See identical proteins and their annotated locations for XP_006513511.1

    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  7. XM_006513447.1XP_006513510.1  synaptotagmin-1 isoform X1

    See identical proteins and their annotated locations for XP_006513510.1

    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
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