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Syt1 synaptotagmin I [ Mus musculus (house mouse) ]

Gene ID: 20979, updated on 21-Apr-2024

Summary

Official Symbol
Syt1provided by MGI
Official Full Name
synaptotagmin Iprovided by MGI
Primary source
MGI:MGI:99667
See related
Ensembl:ENSMUSG00000035864 AllianceGenome:MGI:99667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SytI; G630098F17Rik
Summary
Enables several functions, including calcium ion sensor activity; calcium-dependent phospholipid binding activity; and syntaxin-1 binding activity. Involved in modulation of chemical synaptic transmission; regulation of dopamine secretion; and synaptic vesicle exocytosis. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; spontaneous neurotransmitter secretion; and synchronous neurotransmitter secretion. Located in several cellular components, including glutamatergic synapse; presynaptic membrane; and secretory vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human SYT1 (synaptotagmin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 49.2), frontal lobe adult (RPKM 47.7) and 4 other tissues See more
Orthologs
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Genomic context

Location:
10 D1; 10 56.52 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (108333511..108846852, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (108497650..109010980, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27810 Neighboring gene STARR-seq mESC enhancer starr_27812 Neighboring gene predicted gene, 23105 Neighboring gene PRKC, apoptosis, WT1, regulator Neighboring gene predicted gene, 36283 Neighboring gene predicted gene, 36440 Neighboring gene predicted gene, 36601 Neighboring gene STARR-seq mESC enhancer starr_27824 Neighboring gene STARR-seq mESC enhancer starr_27827 Neighboring gene STARR-seq mESC enhancer starr_27829 Neighboring gene BRCA1/BRCA2-containing complex, subunit 3, domain containing Neighboring gene STARR-seq mESC enhancer starr_27830 Neighboring gene predicted gene, 53628 Neighboring gene predicted gene, 53629

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion sensor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin-1 binding IDA
Inferred from Direct Assay
more info
PubMed 
enables syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
enables syntaxin-3 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in fast, calcium ion-dependent exocytosis of neurotransmitter IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fast, calcium ion-dependent exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neurotransmitter secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of regulated secretory pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spontaneous neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synchronous neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle docking ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dense core granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in dense core granule ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252341.1NP_001239270.1  synaptotagmin-1 isoform 1

    See identical proteins and their annotated locations for NP_001239270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI842617, AK078790, BC042519, BY268027, CD774438
    Consensus CDS
    CCDS24163.1
    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1, Q3TPT3
    Related
    ENSMUSP00000100912.2, ENSMUST00000105276.8
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  2. NM_001252342.1NP_001239271.1  synaptotagmin-1 isoform 2

    See identical proteins and their annotated locations for NP_001239271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses a difference splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AI842617, AK018163, AK133578, BC042519, BY268027, CD774438
    UniProtKB/TrEMBL
    Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  3. NM_001358501.1NP_001345430.1  synaptotagmin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI842617, AK018163, AK133578, BC042519, BY259903, CD774438
    UniProtKB/TrEMBL
    Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  4. NM_001358502.1NP_001345431.1  synaptotagmin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122472, AI842617, AK018163, BC042519, BY259903, CD774438, EL605393
    Consensus CDS
    CCDS24163.1
    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1, Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  5. NM_001358503.1NP_001345432.1  synaptotagmin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AI842617, AK018163, BC042519, BY259903, CD774438, EL605393
    Consensus CDS
    CCDS24163.1
    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1, Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  6. NM_001358504.1NP_001345433.1  synaptotagmin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI842617, AK018163, AK133578, BB624461, BC042519, BY259903, BY268027, CD774438
    UniProtKB/TrEMBL
    Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  7. NM_001358506.1NP_001345435.1  synaptotagmin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI842617, AK018163, AK133578, BB624461, BC042519, BY259903, CD774438
    UniProtKB/TrEMBL
    Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:139261
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:270405
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  8. NM_009306.3NP_033332.1  synaptotagmin-1 isoform 1

    See identical proteins and their annotated locations for NP_033332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AI842617, BC042519, BY238701, BY268027, CD774438
    Consensus CDS
    CCDS24163.1
    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1, Q3TPT3
    Related
    ENSMUSP00000063293.8, ENSMUST00000064054.14
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    108333511..108846852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244984.2XP_030100844.1  synaptotagmin-1 isoform X1

    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1, Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  2. XM_030244985.2XP_030100845.1  synaptotagmin-1 isoform X1

    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1, Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  3. XM_030244986.2XP_030100846.1  synaptotagmin-1 isoform X1

    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1, Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  4. XM_006513448.1XP_006513511.1  synaptotagmin-1 isoform X1

    See identical proteins and their annotated locations for XP_006513511.1

    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1, Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1
  5. XM_006513447.2XP_006513510.1  synaptotagmin-1 isoform X1

    See identical proteins and their annotated locations for XP_006513510.1

    UniProtKB/Swiss-Prot
    P46096
    UniProtKB/TrEMBL
    H6RXZ1, Q3TPT3
    Conserved Domains (2) summary
    cd08385
    Location:142264
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08402
    Location:273408
    C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1