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Lcorl ligand dependent nuclear receptor corepressor-like [ Mus musculus (house mouse) ]

Gene ID: 209707, updated on 2-Nov-2024

Summary

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Official Symbol
Lcorlprovided by MGI
Official Full Name
ligand dependent nuclear receptor corepressor-likeprovided by MGI
Primary source
MGI:MGI:2651932
See related
Ensembl:ENSMUSG00000015882 AllianceGenome:MGI:2651932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlr1; Gm3414
Summary
Predicted to enable histone methyltransferase binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; oocyte; retina; and trunk somite. Orthologous to human LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 2.2), CNS E18 (RPKM 2.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Lcorl in Genome Data Viewer
Location:
5 B3; 5 25.31 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (45854523..46015213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (45697181..45857835, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13005 Neighboring gene RIKEN cDNA 1600023N17 gene Neighboring gene STARR-positive B cell enhancer ABC_E1300 Neighboring gene DDB1 and CUL4 associated factor 16 pseudogene Neighboring gene non-SMC condensin I complex, subunit G Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene DNA-directed RNA polymerase III subunit RPC6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:46248894-46249195 Neighboring gene RIKEN cDNA 4930405L22 gene Neighboring gene STARR-seq mESC enhancer starr_13008 Neighboring gene predicted gene, 40298

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Splicing variants of NOL4 differentially regulate the transcription activity of Mlr1 and Mlr2 in cultured cells. Takayanagi-Kiya S, et al. Zoolog Sci, 2014 Nov. PMID 25366156
  2. Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1). Kunieda T, et al. FEBS Lett, 2003 Jan 30. PMID 12560079
  3. ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34474245, Free PMC Article
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that transactivation activities of Mlr1 and Mlr2 are differentially regulated by splicing variants of NOL4, which are expressed in a tissue-selective manner.
    Title: Splicing variants of NOL4 differentially regulate the transcription activity of Mlr1 and Mlr2 in cultured cells.
  2. identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed predominantly in the spermatocytes of the testis
    Title: Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ligand-dependent nuclear receptor corepressor-like protein
Names
LCoR-like protein
Mblk1-related protein-1
mblk1-related protein 1
transcription factor MLR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163073.2 → NP_001156545.1  ligand-dependent nuclear receptor corepressor-like protein isoform 1

    See identical proteins and their annotated locations for NP_001156545.1

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
    Consensus CDS
    CCDS51499.1
    UniProtKB/Swiss-Prot
    B2RRS7, Q3U285, Q6NZG1, Q8BNH5, Q8BRN7, Q8BRT8, Q8C9J6, Q8CJG4
    Related
    ENSMUSP00000016026.8, ENSMUST00000016026.14
    Conserved Domains (1) summary
    pfam05225
    Location:525 → 570
    HTH_psq; helix-turn-helix, Psq domain

  2. NM_001359871.2 → NP_001346800.1  ligand-dependent nuclear receptor corepressor-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
    UniProtKB/TrEMBL
    A0A0H2UH31
    Related
    ENSMUSP00000140503.3, ENSMUST00000190036.7

  3. NM_001359872.2 → NP_001346801.1  ligand-dependent nuclear receptor corepressor-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
    Consensus CDS
    CCDS89917.1
    UniProtKB/TrEMBL
    E9PXY2, Q8C9B1
    Related
    ENSMUSP00000112416.2, ENSMUST00000121573.8

  4. NM_001359873.2 → NP_001346802.1  ligand-dependent nuclear receptor corepressor-like protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
    Related
    ENSMUST00000067997.11

  5. NM_001359874.2 → NP_001346803.1  ligand-dependent nuclear receptor corepressor-like protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
    UniProtKB/TrEMBL
    A0A087WST0

  6. NM_001428433.1 → NP_001415362.1  ligand-dependent nuclear receptor corepressor-like protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
    UniProtKB/TrEMBL
    A0A571BEC4

  7. NM_001428434.1 → NP_001415363.1  ligand-dependent nuclear receptor corepressor-like protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  8. NM_001428435.1 → NP_001415364.1  ligand-dependent nuclear receptor corepressor-like protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  9. NM_001428436.1 → NP_001415365.1  ligand-dependent nuclear receptor corepressor-like protein isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  10. NM_001428437.1 → NP_001415366.1  ligand-dependent nuclear receptor corepressor-like protein isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  11. NM_001428438.1 → NP_001415367.1  ligand-dependent nuclear receptor corepressor-like protein isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  12. NM_001428439.1 → NP_001415368.1  ligand-dependent nuclear receptor corepressor-like protein isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  13. NM_001428440.1 → NP_001415369.1  ligand-dependent nuclear receptor corepressor-like protein isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  14. NM_001428441.1 → NP_001415370.1  ligand-dependent nuclear receptor corepressor-like protein isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  15. NM_001428442.1 → NP_001415371.1  ligand-dependent nuclear receptor corepressor-like protein isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  16. NM_001428443.1 → NP_001415372.1  ligand-dependent nuclear receptor corepressor-like protein isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  17. NM_001428444.1 → NP_001415373.1  ligand-dependent nuclear receptor corepressor-like protein isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786

  18. NM_172153.4 → NP_742165.1  ligand-dependent nuclear receptor corepressor-like protein isoform 2

    See identical proteins and their annotated locations for NP_742165.1

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
    Consensus CDS
    CCDS19278.1
    UniProtKB/Swiss-Prot
    Q3U285
    Related
    ENSMUSP00000084408.4, ENSMUST00000087164.10
    Conserved Domains (1) summary
    pfam05225
    Location:442 → 487
    HTH_psq; helix-turn-helix, Psq domain

  19. NM_178142.6 → NP_835278.2  ligand-dependent nuclear receptor corepressor-like protein isoform 3

    See identical proteins and their annotated locations for NP_835278.2

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
    Consensus CDS
    CCDS19277.1
    UniProtKB/Swiss-Prot
    Q3U285
    Related
    ENSMUSP00000042677.7, ENSMUST00000045586.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    45854523..46015213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

  2. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    45877009..45884920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503818.5 → XP_006503881.1  ligand-dependent nuclear receptor corepressor-like protein isoform X1

    Related
    ENSMUSP00000158672.2, ENSMUST00000238522.2
    Conserved Domains (1) summary
    pfam15090
    Location:1402 → 1846
    DUF4553; Domain of unknown function (DUF4553)

  2. XM_036164968.1 → XP_036020861.1  ligand-dependent nuclear receptor corepressor-like protein isoform X2

    Conserved Domains (1) summary
    pfam15090
    Location:1332 → 1776
    DUF4553; Domain of unknown function (DUF4553)

  3. XM_030254342.2 → XP_030110202.1  ligand-dependent nuclear receptor corepressor-like protein isoform X7

    UniProtKB/TrEMBL
    E9PXY2, Q8C9B1

  4. XM_036164972.1 → XP_036020865.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    Conserved Domains (1) summary
    pfam05225
    Location:366 → 411
    HTH_psq; helix-turn-helix, Psq domain

  5. XM_030254341.2 → XP_030110201.1  ligand-dependent nuclear receptor corepressor-like protein isoform X5

    Conserved Domains (1) summary
    pfam05225
    Location:439 → 484
    HTH_psq; helix-turn-helix, Psq domain

  6. XM_036164971.1 → XP_036020864.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    Conserved Domains (1) summary
    pfam05225
    Location:366 → 411
    HTH_psq; helix-turn-helix, Psq domain

  7. XM_036164970.1 → XP_036020863.1  ligand-dependent nuclear receptor corepressor-like protein isoform X4

    Conserved Domains (1) summary
    pfam05225
    Location:442 → 487
    HTH_psq; helix-turn-helix, Psq domain

  8. XM_036164969.1 → XP_036020862.1  ligand-dependent nuclear receptor corepressor-like protein isoform X3

    Conserved Domains (1) summary
    pfam05225
    Location:455 → 500
    HTH_psq; helix-turn-helix, Psq domain

  9. XM_030254345.2 → XP_030110205.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

    UniProtKB/TrEMBL
    A0A0H2UH31

  10. XM_030254343.2 → XP_030110203.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

  11. XM_030254344.1 → XP_030110204.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

RNA

  1. XR_004942478.1 RNA Sequence

  2. XR_004942488.1 RNA Sequence

  3. XR_004942487.1 RNA Sequence

  4. XR_004942483.1 RNA Sequence

  5. XR_004942479.1 RNA Sequence

  6. XR_004942482.1 RNA Sequence

  7. XR_004942481.1 RNA Sequence

  8. XR_004942484.1 RNA Sequence

  9. XR_004942480.1 RNA Sequence

  10. XR_004942485.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U285.1 GenPept UniProtKB/Swiss-Prot:Q3U285

Gene LinkOut

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