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Lcorl ligand dependent nuclear receptor corepressor-like [ Mus musculus (house mouse) ]

Gene ID: 209707, updated on 26-Sep-2022

Summary

Official Symbol
Lcorlprovided by MGI
Official Full Name
ligand dependent nuclear receptor corepressor-likeprovided by MGI
Primary source
MGI:MGI:2651932
See related
Ensembl:ENSMUSG00000015882 AllianceGenome:MGI:2651932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlr1
Summary
Predicted to enable histone methyltransferase binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II and transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; oocyte; retina; and trunk somite. Orthologous to human LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 2.2), CNS E18 (RPKM 2.0) and 18 other tissues See more
Orthologs
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Genomic context

See Lcorl in Genome Data Viewer
Location:
5; 5 B3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (45854523..46015213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (45697181..45857835, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600023N17 gene Neighboring gene DDB1 and CUL4 associated factor 16 pseudogene Neighboring gene non-SMC condensin I complex, subunit G Neighboring gene predicted gene 3414 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene DNA-directed RNA polymerase III subunit RPC6 pseudogene Neighboring gene RIKEN cDNA 4930405L22 gene Neighboring gene predicted gene, 40298

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables histone methyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ligand-dependent nuclear receptor corepressor-like protein
Names
LCoR-like protein
Mblk1-related protein-1
mblk1-related protein 1
transcription factor MLR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163073.1NP_001156545.1  ligand-dependent nuclear receptor corepressor-like protein isoform 1

    See identical proteins and their annotated locations for NP_001156545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC093341, AC158786, AK041987
    Consensus CDS
    CCDS51499.1
    UniProtKB/Swiss-Prot
    Q3U285, Q8CJG4
    UniProtKB/TrEMBL
    A0A8C6IGV3
    Related
    ENSMUSP00000016026.8, ENSMUST00000016026.14
    Conserved Domains (1) summary
    pfam05225
    Location:525570
    HTH_psq; helix-turn-helix, Psq domain
  2. NM_001359871.1NP_001346800.1  ligand-dependent nuclear receptor corepressor-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
    UniProtKB/TrEMBL
    A0A6P7QYM3
    Related
    ENSMUSP00000140503.3, ENSMUST00000190036.7
  3. NM_001359872.1NP_001346801.1  ligand-dependent nuclear receptor corepressor-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC093341, AK042567
    Consensus CDS
    CCDS89917.1
    UniProtKB/TrEMBL
    E9PXY2
    Related
    ENSMUSP00000112416.2, ENSMUST00000121573.8
  4. NM_001359873.1NP_001346802.1  ligand-dependent nuclear receptor corepressor-like protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158786, AK083689
    Related
    ENSMUST00000067997.11
  5. NM_001359874.1NP_001346803.1  ligand-dependent nuclear receptor corepressor-like protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC093341, AC158786
  6. NM_172153.3NP_742165.1  ligand-dependent nuclear receptor corepressor-like protein isoform 2

    See identical proteins and their annotated locations for NP_742165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC093341, AC158786
    Consensus CDS
    CCDS19278.1
    UniProtKB/Swiss-Prot
    Q3U285
    Related
    ENSMUSP00000084408.4, ENSMUST00000087164.10
    Conserved Domains (1) summary
    pfam05225
    Location:442487
    HTH_psq; helix-turn-helix, Psq domain
  7. NM_178142.5NP_835278.2  ligand-dependent nuclear receptor corepressor-like protein isoform 3

    See identical proteins and their annotated locations for NP_835278.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, and 3' coding region compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC158786, AK033995, AK043498, BP770153
    Consensus CDS
    CCDS19277.1
    UniProtKB/Swiss-Prot
    Q3U285
    Related
    ENSMUSP00000042677.7, ENSMUST00000045586.13

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    45854523..46015213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503818.5XP_006503881.1  ligand-dependent nuclear receptor corepressor-like protein isoform X1

    UniProtKB/TrEMBL
    A0A571BEC4
    Related
    ENSMUSP00000158672.2, ENSMUST00000238522.2
    Conserved Domains (1) summary
    pfam15090
    Location:14021846
    DUF4553; Domain of unknown function (DUF4553)
  2. XM_036164968.1XP_036020861.1  ligand-dependent nuclear receptor corepressor-like protein isoform X2

    Conserved Domains (1) summary
    pfam15090
    Location:13321776
    DUF4553; Domain of unknown function (DUF4553)
  3. XM_030254342.2XP_030110202.1  ligand-dependent nuclear receptor corepressor-like protein isoform X7

    UniProtKB/TrEMBL
    E9PXY2
  4. XM_036164972.1XP_036020865.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    Conserved Domains (1) summary
    pfam05225
    Location:366411
    HTH_psq; helix-turn-helix, Psq domain
  5. XM_030254341.2XP_030110201.1  ligand-dependent nuclear receptor corepressor-like protein isoform X5

    Conserved Domains (1) summary
    pfam05225
    Location:439484
    HTH_psq; helix-turn-helix, Psq domain
  6. XM_036164971.1XP_036020864.1  ligand-dependent nuclear receptor corepressor-like protein isoform X6

    Conserved Domains (1) summary
    pfam05225
    Location:366411
    HTH_psq; helix-turn-helix, Psq domain
  7. XM_036164970.1XP_036020863.1  ligand-dependent nuclear receptor corepressor-like protein isoform X4

    Conserved Domains (1) summary
    pfam05225
    Location:442487
    HTH_psq; helix-turn-helix, Psq domain
  8. XM_036164969.1XP_036020862.1  ligand-dependent nuclear receptor corepressor-like protein isoform X3

    Conserved Domains (1) summary
    pfam05225
    Location:455500
    HTH_psq; helix-turn-helix, Psq domain
  9. XM_030254345.2XP_030110205.1  ligand-dependent nuclear receptor corepressor-like protein isoform X10

    UniProtKB/TrEMBL
    A0A6P7RAP8
  10. XM_030254343.2XP_030110203.1  ligand-dependent nuclear receptor corepressor-like protein isoform X8

  11. XM_030254344.1XP_030110204.1  ligand-dependent nuclear receptor corepressor-like protein isoform X9

RNA

  1. XR_004942478.1 RNA Sequence

  2. XR_004942488.1 RNA Sequence

  3. XR_004942487.1 RNA Sequence

  4. XR_004942483.1 RNA Sequence

  5. XR_004942479.1 RNA Sequence

  6. XR_004942482.1 RNA Sequence

  7. XR_004942481.1 RNA Sequence

  8. XR_004942484.1 RNA Sequence

  9. XR_004942480.1 RNA Sequence

  10. XR_004942485.1 RNA Sequence