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Eif2b1 eukaryotic translation initiation factor 2B, subunit 1 (alpha) [ Mus musculus (house mouse) ]

Gene ID: 209354, updated on 5-Aug-2018

Summary

Official Symbol
Eif2b1provided by MGI
Official Full Name
eukaryotic translation initiation factor 2B, subunit 1 (alpha)provided by MGI
Primary source
MGI:MGI:2384802
See related
Ensembl:ENSMUSG00000029388 Vega:OTTMUSG00000024473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EIF2BA; D5Ertd406e
Summary
This gene encodes the alpha subunit of the eukaryotic translation initiation factor complex 2B (eIF2B). The eIF2B complex is a heterodecamer comprised of two molecules each of alpha, beta, gamma, delta and epsilon subunits. The eIF2B complex is a critical regulator of protein synthesis acting as the guanine nucleotide exchange factor for eIF2 to enable the formation of ternary complex that is required for the initiation of mRNA translation. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in placenta adult (RPKM 18.0), liver E14 (RPKM 13.3) and 28 other tissues See more
Orthologs

Genomic context

See Eif2b1 in Genome Data Viewer
Location:
5 F; 5 63.67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (124570214..124579131, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (125020223..125029066, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 Neighboring gene general transcription factor IIH, polypeptide 3 Neighboring gene tectonic family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6458

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GDP binding ISO
Inferred from Sequence Orthology
more info
 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
 
response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
response to glucose ISO
Inferred from Sequence Orthology
more info
 
response to heat ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
translation ISO
Inferred from Sequence Orthology
more info
 
translational initiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
eukaryotic translation initiation factor 2 complex ISO
Inferred from Sequence Orthology
more info
 
eukaryotic translation initiation factor 2B complex ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
translation initiation factor eIF-2B subunit alpha
Names
eIF-2B GDP-GTP exchange factor subunit alpha
eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145371.4NP_663346.1  translation initiation factor eIF-2B subunit alpha

    See identical proteins and their annotated locations for NP_663346.1

    Status: REVIEWED

    Source sequence(s)
    AK133695, DV649595
    Consensus CDS
    CCDS39282.1
    UniProtKB/Swiss-Prot
    Q99LC8
    UniProtKB/TrEMBL
    Q3UZR8
    Related
    ENSMUSP00000031334.8, OTTMUSP00000029257, ENSMUST00000031334.14, OTTMUST00000060023
    Conserved Domains (2) summary
    COG1184
    Location:5305
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:17293
    IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    124570214..124579131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530275.3XP_006530338.1  translation initiation factor eIF-2B subunit alpha isoform X1

    Conserved Domains (2) summary
    COG1184
    Location:16198
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:17186
    IF-2B; Initiation factor 2 subunit family
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