U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abcc8 ATP-binding cassette, sub-family C member 8 [ Mus musculus (house mouse) ]

Gene ID: 20927, updated on 13-Feb-2024

Summary

Official Symbol
Abcc8provided by MGI
Official Full Name
ATP-binding cassette, sub-family C member 8provided by MGI
Primary source
MGI:MGI:1352629
See related
Ensembl:ENSMUSG00000040136 AllianceGenome:MGI:1352629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sur; SUR1; D930031B21Rik
Summary
Predicted to enable ATPase-coupled cation transmembrane transporter activity; potassium channel activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in plasma membrane. Is expressed in cerebral cortex; foregut-midgut junction; heart ventricle; and retina inner nuclear layer. Used to study hyperinsulinemic hypoglycemia and transient neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; glucose metabolism disease (multiple); hypertension; and leucine-sensitive hypoglycemia of infancy. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 8.6), heart adult (RPKM 8.3) and 11 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Abcc8 in Genome Data Viewer
Location:
7 B3; 7 29.66 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45753952..45829441, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46104523..46180039, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene erythrocyte protein band 4.1-like 5 pseudogene Neighboring gene potassium inwardly rectifying channel, subfamily J, member 11 Neighboring gene predicted gene, 51481 Neighboring gene USH1 protein network component harmonin Neighboring gene STARR-seq mESC enhancer starr_18861 Neighboring gene otogelin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATPase-coupled monoatomic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glutamate secretion, neurotransmission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood-brain barrier permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tight junction disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of uterine smooth muscle relaxation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to pH ISO
Inferred from Sequence Orthology
more info
 
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in visual learning ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of inward rectifying potassium channel ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-binding cassette sub-family C member 8
Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
sulfonylurea receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357538.2NP_001344467.1  ATP-binding cassette sub-family C member 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115036, AC120135
    Conserved Domains (1) summary
    cl26602
    Location:2241578
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
  2. NM_001403104.1NP_001390033.1  ATP-binding cassette sub-family C member 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115036, AC120135
  3. NM_001403109.1NP_001390038.1  ATP-binding cassette sub-family C member 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC120135
    UniProtKB/TrEMBL
    Q8BIU4
    Related
    ENSMUST00000210986.2
  4. NM_001403110.1NP_001390039.1  ATP-binding cassette sub-family C member 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115036, AC120135
  5. NM_011510.4NP_035640.2  ATP-binding cassette sub-family C member 8 isoform 1

    See identical proteins and their annotated locations for NP_035640.2

    Status: VALIDATED

    Source sequence(s)
    AC115036, AC120135
    Consensus CDS
    CCDS21275.1
    UniProtKB/TrEMBL
    B2RUS7
    Related
    ENSMUSP00000033123.7, ENSMUST00000033123.8
    Conserved Domains (4) summary
    cd03288
    Location:13491588
    ABCC_SUR2; ATP-binding cassette domain 2 of the sulfonylurea receptor SUR
    TIGR01271
    Location:2231588
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:10301301
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:679913
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45753952..45829441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152860.1XP_036008753.1  ATP-binding cassette sub-family C member 8 isoform X1

    Conserved Domains (1) summary
    TIGR00957
    Location:2241594
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  2. XM_030242316.2XP_030098176.1  ATP-binding cassette sub-family C member 8 isoform X3

    Conserved Domains (1) summary
    TIGR00957
    Location:2241340
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RNA

  1. XR_001785506.2 RNA Sequence

  2. XR_001785505.2 RNA Sequence

  3. XR_882027.2 RNA Sequence

  4. XR_001785512.2 RNA Sequence

  5. XR_001785502.2 RNA Sequence

  6. XR_001785511.2 RNA Sequence

  7. XR_003946427.2 RNA Sequence

  8. XR_004934049.1 RNA Sequence

  9. XR_882028.2 RNA Sequence