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Vps8 VPS8 CORVET complex subunit [ Mus musculus (house mouse) ]

Gene ID: 209018, updated on 2-Nov-2024

Summary

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Official Symbol
Vps8provided by MGI
Official Full Name
VPS8 CORVET complex subunitprovided by MGI
Primary source
MGI:MGI:2146407
See related
Ensembl:ENSMUSG00000033653 AllianceGenome:MGI:2146407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0804
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in endosomal vesicle fusion and protein targeting to vacuole. Part of CORVET complex. Is expressed in cranial ganglion; dorsal root ganglion; and neural retina. Orthologous to human VPS8 (VPS8 subunit of CORVET complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.3), cortex adult (RPKM 6.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Vps8 in Genome Data Viewer
Location:
16 B1; 16 12.69 cM
Exon count:
50
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (21241859..21463431)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (21423118..21644681)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36224 Neighboring gene predicted gene, 36150 Neighboring gene predicted gene, 53939 Neighboring gene STARR-seq mESC enhancer starr_40364 Neighboring gene STARR-positive B cell enhancer mm9_chr16:21488490-21488791 Neighboring gene predicted gene, 50612 Neighboring gene STARR-positive B cell enhancer ABC_E10895 Neighboring gene STARR-positive B cell enhancer mm9_chr16:21630703-21631004 Neighboring gene STARR-positive B cell enhancer mm9_chr16:21631987-21632288 Neighboring gene RIKEN cDNA 2510009E07 gene Neighboring gene STARR-seq mESC enhancer starr_40369 Neighboring gene STARR-positive B cell enhancer ABC_E11607 Neighboring gene enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Low pup survival rate is associated with maternal Naq3 genotype and hypothalamic Vps8 expression levels in mice. Suto JI, et al. Congenit Anom (Kyoto), 2021 May. PMID 33289187
  2. Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. Perini ED, et al. Traffic, 2014 Dec. PMID 25266290
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low pup survival rate is associated with maternal Naq3 genotype and hypothalamic Vps8 expression levels in mice.
    Title: Low pup survival rate is associated with maternal Naq3 genotype and hypothalamic Vps8 expression levels in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38232

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endosomal vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal vesicle fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CORVET complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CORVET complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 8 homolog
Names
vacuolar protein sorting 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081366.1 → NP_001074835.1  vacuolar protein sorting-associated protein 8 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130214, AC133597, AC164549
    Conserved Domains (4) summary
    sd00039
    Location:202 → 239
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1257 → 1311
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:614 → 796
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:197 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001285893.1 → NP_001272822.1  vacuolar protein sorting-associated protein 8 homolog isoform 1

    See identical proteins and their annotated locations for NP_001272822.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC130214, AC164549, BC055323
    Consensus CDS
    CCDS70701.1
    UniProtKB/Swiss-Prot
    Q0P5W1, Q3UR93, Q80TR5, Q8K280
    Related
    ENSMUSP00000112937.2, ENSMUST00000117598.8
    Conserved Domains (4) summary
    sd00039
    Location:200 → 237
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1255 → 1309
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:612 → 794
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:195 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001285894.1 → NP_001272823.1  vacuolar protein sorting-associated protein 8 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two in-frame exons in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC130214, AC164549, AK122375
    Consensus CDS
    CCDS70700.1
    Related
    ENSMUSP00000112636.2, ENSMUST00000118923.8
    Conserved Domains (5) summary
    smart00249
    Location:1228 → 1280
    PHD; PHD zinc finger
    pfam12816
    Location:614 → 796
    Vps8; Golgi CORVET complex core vacuolar protein 8
    sd00039
    Location:202 → 239
    7WD40; WD40 repeat [structural motif]
    cl00271
    Location:933 → 1048
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl02567
    Location:197 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    21241859..21463431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521955.5 → XP_006522018.1  vacuolar protein sorting-associated protein 8 homolog isoform X1

    See identical proteins and their annotated locations for XP_006522018.1

    Conserved Domains (4) summary
    sd00039
    Location:202 → 239
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1257 → 1311
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:614 → 796
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:197 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_036159862.1 → XP_036015755.1  vacuolar protein sorting-associated protein 8 homolog isoform X2

    UniProtKB/Swiss-Prot
    Q0P5W1, Q3UR93, Q80TR5, Q8K280
    Conserved Domains (4) summary
    sd00039
    Location:200 → 237
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1255 → 1309
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:612 → 794
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:195 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006521956.3 → XP_006522019.1  vacuolar protein sorting-associated protein 8 homolog isoform X4

    Conserved Domains (4) summary
    sd00039
    Location:202 → 239
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1257 → 1311
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:614 → 796
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:197 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_036159864.1 → XP_036015757.1  vacuolar protein sorting-associated protein 8 homolog isoform X5

    Related
    ENSMUSP00000093905.5, ENSMUST00000096191.11
    Conserved Domains (4) summary
    sd00039
    Location:200 → 237
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1255 → 1309
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:612 → 794
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:195 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_036159863.1 → XP_036015756.1  vacuolar protein sorting-associated protein 8 homolog isoform X3

    Conserved Domains (4) summary
    sd00039
    Location:202 → 239
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1257 → 1311
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:614 → 796
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:197 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_036159865.1 → XP_036015758.1  vacuolar protein sorting-associated protein 8 homolog isoform X6

    Conserved Domains (4) summary
    sd00039
    Location:202 → 239
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1257 → 1311
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:614 → 796
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:197 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_036159861.1 → XP_036015754.1  vacuolar protein sorting-associated protein 8 homolog isoform X2

    UniProtKB/Swiss-Prot
    Q0P5W1, Q3UR93, Q80TR5, Q8K280
    Conserved Domains (4) summary
    sd00039
    Location:200 → 237
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1255 → 1309
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:612 → 794
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:195 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_006521954.4 → XP_006522017.1  vacuolar protein sorting-associated protein 8 homolog isoform X1

    See identical proteins and their annotated locations for XP_006522017.1

    Conserved Domains (4) summary
    sd00039
    Location:202 → 239
    7WD40; WD40 repeat [structural motif]
    cd16687
    Location:1257 → 1311
    RING-H2_Vps8; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 8 (Vps8) and similar proteins
    pfam12816
    Location:614 → 796
    Vps8; Golgi CORVET complex core vacuolar protein 8
    cl29593
    Location:197 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145948.2: Suppressed sequence

    Description
    NM_145948.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P5W1.1 GenPept UniProtKB/Swiss-Prot:Q0P5W1

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