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Dock3 dedicator of cyto-kinesis 3 [ Mus musculus (house mouse) ]

Gene ID: 208869, updated on 5-Mar-2024

Summary

Official Symbol
Dock3provided by MGI
Official Full Name
dedicator of cyto-kinesis 3provided by MGI
Primary source
MGI:MGI:2429763
See related
Ensembl:ENSMUSG00000039716 AllianceGenome:MGI:2429763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PBP; MOCA; mKIAA0299
Summary
Predicted to enable SH3 domain binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Located in cytoplasm. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human DOCK3 (dedicator of cytokinesis 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 24.4), cortex adult (RPKM 21.6) and 7 other tissues See more
Orthologs
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Genomic context

See Dock3 in Genome Data Viewer
Location:
9 F1; 9 57.98 cM
Exon count:
54
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106770024..107109108, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106892825..107232330, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9334 Neighboring gene STARR-positive B cell enhancer ABC_E460 Neighboring gene RNA binding motif protein 15B Neighboring gene mesencephalic astrocyte-derived neurotrophic factor Neighboring gene predicted gene, 18542 Neighboring gene STARR-seq mESC enhancer starr_25166 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 pseudogene Neighboring gene predicted gene, 22454 Neighboring gene predicted gene, 23595 Neighboring gene myc-like oncogene, s-myc protein pseudogene Neighboring gene predicted gene, 51734 Neighboring gene STARR-seq mESC enhancer starr_25168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107192213-107192396 Neighboring gene mitogen-activated protein kinase-activated protein kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
dedicator of cytokinesis protein 3
Names
modifier of cell adhesion
presenilin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153413.2NP_700462.2  dedicator of cytokinesis protein 3

    See identical proteins and their annotated locations for NP_700462.2

    Status: VALIDATED

    Source sequence(s)
    AC121608, AI604896, AK147385, BC040770, BE656508, BF465833, CF744136, CJ124323, CK781165
    Consensus CDS
    CCDS40760.1
    UniProtKB/Swiss-Prot
    Q8CIQ7
    UniProtKB/TrEMBL
    F8VPQ1
    Related
    ENSMUSP00000047652.5, ENSMUST00000044532.11
    Conserved Domains (4) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106770024..107109108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244177.2XP_030100037.1  dedicator of cytokinesis protein 3 isoform X6

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (5) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12121603
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam03154
    Location:17282035
    Atrophin-1; Atrophin-1 family
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus
  2. XM_011242872.3XP_011241174.1  dedicator of cytokinesis protein 3 isoform X4

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (5) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12211612
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam03154
    Location:17372044
    Atrophin-1; Atrophin-1 family
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus
  3. XM_011242871.3XP_011241173.1  dedicator of cytokinesis protein 3 isoform X3

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (5) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12261617
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam03154
    Location:17422049
    Atrophin-1; Atrophin-1 family
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus
  4. XM_036154771.1XP_036010664.1  dedicator of cytokinesis protein 3 isoform X9

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (4) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus
  5. XM_011242873.3XP_011241175.1  dedicator of cytokinesis protein 3 isoform X5

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (5) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam03154
    Location:17611999
    Atrophin-1; Atrophin-1 family
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus
  6. XM_017313260.3XP_017168749.1  dedicator of cytokinesis protein 3 isoform X7

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (4) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus
  7. XM_011242870.3XP_011241172.1  dedicator of cytokinesis protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (5) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam03154
    Location:17512052
    Atrophin-1; Atrophin-1 family
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus
  8. XM_011242875.4XP_011241177.1  dedicator of cytokinesis protein 3 isoform X11

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (4) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus
  9. XM_011242869.3XP_011241171.1  dedicator of cytokinesis protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (5) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam03154
    Location:17512058
    Atrophin-1; Atrophin-1 family
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus
  10. XM_030244178.2XP_030100038.1  dedicator of cytokinesis protein 3 isoform X10

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (4) summary
    cd08695
    Location:267456
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:10821473
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    pfam03154
    Location:15981905
    Atrophin-1; Atrophin-1 family
    pfam16172
    Location:3259
    DOCK_N; DOCK N-terminus
  11. XM_006511691.3XP_006511754.1  dedicator of cytokinesis protein 3 isoform X8

    UniProtKB/Swiss-Prot
    Q8CIQ7
    Conserved Domains (4) summary
    cd08695
    Location:420609
    C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
    cd11704
    Location:12351626
    DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
    cd12048
    Location:1065
    SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
    pfam16172
    Location:69412
    DOCK_N; DOCK N-terminus