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Stat6 signal transducer and activator of transcription 6 [ Mus musculus (house mouse) ]

Gene ID: 20852, updated on 12-Sep-2021

Summary

Official Symbol
Stat6provided by MGI
Official Full Name
signal transducer and activator of transcription 6provided by MGI
Primary source
MGI:MGI:103034
See related
Ensembl:ENSMUSG00000002147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Ubiquitous expression in spleen adult (RPKM 35.4), thymus adult (RPKM 34.3) and 24 other tissues See more
Orthologs
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Genomic context

See Stat6 in Genome Data Viewer
Location:
10 D3; 10 74.59 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127478855..127496856)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127642955..127660987)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127080042..127098043)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 1 Neighboring gene predicted gene 16217 Neighboring gene predicted gene, 40802 Neighboring gene predicted gene, 30989 Neighboring gene RIKEN cDNA 1700012D01 gene Neighboring gene Ngfi-A binding protein 2 Neighboring gene predicted gene 16230

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within T-helper 1 cell lineage commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive nitrogen species ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in interleukin-4-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-4-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of type 2 immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of isotype switching to IgE isotypes IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal transducer and transcription activator 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009284.2NP_033310.2  signal transducer and transcription activator 6

    See identical proteins and their annotated locations for NP_033310.2

    Status: VALIDATED

    Source sequence(s)
    AK149563, AK163053, BM122652
    Consensus CDS
    CCDS36082.1
    UniProtKB/Swiss-Prot
    P52633
    Related
    ENSMUSP00000089708.6, ENSMUST00000092074.12
    Conserved Domains (5) summary
    cd10377
    Location:517646
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    pfam01017
    Location:178271
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:273526
    STAT_bind; STAT protein, DNA binding domain
    pfam14596
    Location:655837
    STAT6_C; STAT6 C-terminal
    cl03749
    Location:2115
    STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127478855..127496856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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