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Stat5a signal transducer and activator of transcription 5A [ Mus musculus (house mouse) ]

Gene ID: 20850, updated on 3-Jun-2018
Official Symbol
Stat5aprovided by MGI
Official Full Name
signal transducer and activator of transcription 5Aprovided by MGI
Primary source
MGI:MGI:103036
See related
Ensembl:ENSMUSG00000004043 Vega:OTTMUSG00000002125
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STAT5; AA959963
Expression
Broad expression in thymus adult (RPKM 40.3), mammary gland adult (RPKM 29.6) and 20 other tissues See more
Orthologs
human all
See Stat5a in Genome Data Viewer
Location:
11 D; 11 63.77 cM
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (100859351..100885169)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (100720665..100746483)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 3 Neighboring gene predicted gene, 46295 Neighboring gene caveolae associated 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury. Eddy WE, et al. J Immunol, 2017 Jun 15. PMID 28500076, Free PMC Article
  2. Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations. Wang Z, et al. Oncotarget, 2017 Apr 4. PMID 28390194, Free PMC Article
  3. Deletion of liver-specific STAT5 gene alters the expression of bile acid metabolism genes and reduces liver damage in lithogenic diet-fed mice. Baik M, et al. J Nutr Biochem, 2017 Jan. PMID 27816761
  4. Lipoxin A4 protects against lipopolysaccharide-induced sepsis by promoting innate response activator B cells generation. Cheng Q, et al. Int Immunopharmacol, 2016 Oct. PMID 27494686
  5. Muscle-specific deletion of signal transducer and activator of transcription 5 augments lipid accumulation in skeletal muscle and liver of mice in response to high-fat diet. Baik M, et al. Eur J Nutr, 2017 Mar. PMID 26582580

See all (465) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. findings indicate that STAT5 contributes to the remarkable IL-3-mediated inhibition of RANKL-induced osteoclastogenesis by activating Id genes and their associated pathways.
    Title: STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis.
  2. Results suggest activation of H2AX via promoter demethylation in specific populations of basal mammary cells that is induced by a signal from neighboring luminal cells with hyper STAT5 activity.
    Title: Luminal STAT5 mediates H2AX promoter activity in distinct population of basal mammary epithelial cells.
  3. On the basis of our ChIP data and these previous findings, we hypothesize that PDC may modulate STAT5's ability to regulate gene expression by controlling histone or STAT5 acetylation
    Title: Pyruvate dehydrogenase complex (PDC) subunits moonlight as interaction partners of phosphorylated STAT5 in adipocytes and adipose tissue.
  4. STAT5 gene deletion had a minor effect on cholesterol metabolism, as evidenced by no changes in expression of cholesterol transport and cholesterol synthesis genes, and numeric changes in serum and liver cholesterol levels. These minor changes in cholesterol metabolism may not have been sufficient to influence on cholesterol crystal and gallstone formation in lithogenic diet-fed STAT5 LKO mice.
    Title: Deletion of liver-specific STAT5 gene alters the expression of bile acid metabolism genes and reduces liver damage in lithogenic diet-fed mice.
  5. Stat5 deficiency has a strong impact upon transcriptional heterogeneity in single sorted c-Kit+Lin-Sca-1+ (KLS) cells or CD150+CD48- KLS long-term repopulating hematopoietic stem cells.
    Title: Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations.
  6. mice carrying Stat5a/b inactivation specifically in kisspeptin cells were generated. These mutants exhibited an early onset of estrous cyclicity, indicating that STAT5 transcription factors exert an inhibitory effect on the timing of puberty.
    Title: STAT5 signaling in kisspeptin cells regulates the timing of puberty.
  7. these data suggest that ROCK2 signaling plays a critical role in controlling the development of TFH cells induced by autoimmune conditions through reciprocal regulation of STAT3 and STAT5 activation.
    Title: ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings.
  8. Upon deletion of the STAT5 response elements from the Socs2 promoter in mice, cytokine induction was abrogated, while basal activity remained intact. Our data suggest that promoter-bound STAT5 modulates cytokine responses and enhancer-bound STAT5 is mandatory for gene activation.
    Title: Lineage-Specific and Non-specific Cytokine-Sensing Genes Respond Differentially to the Master Regulator STAT5.
  9. Instead, we find that STAT5B is dominant over STAT5A in CD4(+) 'helper' T cells for both effector and regulatory (Treg) responses and, therefore, uniquely necessary for immunological tolerance.
    Title: Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.
  10. Data indicate that obesity-induced insulin resistance and lipotoxicity can be treated with ginsenoside Rg3, which acts though the STAT5-PPAR gamma pathway in vivo and in vitro.
    Title: Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPARγ.
Submit: New GeneRIF Correction See all GeneRIFs (261)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Genotypes

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
    Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Acute myeloid leukemia, conserved biosystem (from KEGG)
    Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
    Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
  • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
    Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Chronic myeloid leukemia, conserved biosystem (from KEGG)
    Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Downstream signal transduction, organism-specific biosystem (from REACTOME)
    Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • EPO Receptor Signaling, organism-specific biosystem (from WikiPathways)
    EPO Receptor Signaling, organism-specific biosystemThe erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activat...
  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
    ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
  • Growth hormone receptor signaling, organism-specific biosystem (from REACTOME)
    Growth hormone receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-5 Signaling Pathway, organism-specific biosystem
    IL-5 Signaling Pathway
  • IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 signaling Pathway, organism-specific biosystem
    IL-6 signaling Pathway
  • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-7 Signaling Pathway, organism-specific biosystem
    IL-7 Signaling Pathway
  • IL-9 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-9 Signaling Pathway, organism-specific biosystem
    IL-9 Signaling Pathway
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interleukin-7 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-7 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • JAK-STAT signaling, organism-specific biosystem (from KEGG)
    JAK-STAT signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • JAK-STAT signaling, conserved biosystem (from KEGG)
    JAK-STAT signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Mus musculus biological processes, organism-specific biosystem (from REACTOME)
    Mus musculus biological processes, organism-specific biosystemCertain mouse pathways have been fully manually curated in Reactome in order to support the manual inference of well-conserved but less well-studied human pathways. These pathways include Circadian...
  • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
    Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
  • Non-small cell lung cancer, conserved biosystem (from KEGG)
    Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
  • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Nuclear signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
    Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Prolactin signaling pathway, conserved biosystem (from KEGG)
    Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemLeptin, a circulating adipokine, and its receptor Lepr control food intake and energy balance (recently reviewed in Wauman and Tavernier 2011, Bjorbaek 2009, Morris and Rui 2009, Myers et al. 2008). ...
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TYROBP Causal Network, organism-specific biosystem (from WikiPathways)
    TYROBP Causal Network, organism-specific biosystemBased on Figure 6A from Zhang et al. Converted from the original human network to mouse. Gimap2 and Lgals9 (light gray) have no mouse ortholog.
  • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
    Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
  • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
    Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
  • Th17 cell differentiation, organism-specific biosystem (from KEGG)
    Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Th17 cell differentiation, conserved biosystem (from KEGG)
    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • White fat cell differentiation, organism-specific biosystem (from WikiPathways)
    White fat cell differentiation, organism-specific biosystemThe transcription factors involved in white fat cell differentiation are shown, specifically their pattern of activity from the preadipocyte to the adipocyte (fat cells) stage. Adipose tissue, compos...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
2-oxoglutarate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
JAK-STAT cascade IDA
Inferred from Direct Assay
more info
 PubMed 
JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
  
JAK-STAT cascade involved in growth hormone signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Peyer's patch development IGI
Inferred from Genetic Interaction
more info
 PubMed 
T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
 PubMed 
T cell homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
allantoin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 PubMed 
cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 PubMed 
citrate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
creatine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
creatinine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
development of secondary female sexual characteristics IMP
Inferred from Mutant Phenotype
more info
 PubMed 
development of secondary male sexual characteristics IGI
Inferred from Genetic Interaction
more info
 PubMed 
development of secondary male sexual characteristics IMP
Inferred from Mutant Phenotype
more info
 PubMed 
epithelial cell differentiation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
female pregnancy IGI
Inferred from Genetic Interaction
more info
 PubMed 
isoleucine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
lactation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
lipid storage IGI
Inferred from Genetic Interaction
more info
 PubMed 
luteinization IGI
Inferred from Genetic Interaction
more info
 PubMed 
mammary gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
mammary gland epithelium development IGI
Inferred from Genetic Interaction
more info
 PubMed 
mammary gland epithelium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
mammary gland involution ISO
Inferred from Sequence Orthology
more info
  
natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
negative regulation of erythrocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
negative regulation of mast cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
oxaloacetate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of B cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of activated T cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
positive regulation of gamma-delta T cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of interleukin-2 biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of lymphocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of mast cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of mast cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
regulation of multicellular organism growth IDA
Inferred from Direct Assay
more info
 PubMed 
regulation of steroid metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
  
response to peptide hormone IDA
Inferred from Direct Assay
more info
 PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
  
succinate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
taurine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
  
valine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
  
cytosol ISO
Inferred from Sequence Orthology
more info
  
nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
signal transducer and activator of transcription 5A
Names
mammary gland factor STAT5A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164062.1 → NP_001157534.1  signal transducer and activator of transcription 5A isoform 2

    See identical proteins and their annotated locations for NP_001157534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), also known as delta E18, lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA718536, AK134012, BY277646, EU249543
    Consensus CDS
    CCDS48933.1
    UniProtKB/TrEMBL
    B2C3G8, Q3UZ79
    Related
    ENSMUSP00000102980.2, ENSMUST00000107357.3
    Conserved Domains (4) summary
    cd10421
    Location:573 → 708
    SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
    pfam01017
    Location:141 → 330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332 → 582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  2. NM_001362680.1 → NP_001349609.1  signal transducer and activator of transcription 5A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591466, BY478099
    Conserved Domains (4) summary
    cd10421
    Location:573 → 712
    SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
    pfam01017
    Location:141 → 330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332 → 582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  3. NM_011488.3 → NP_035618.1  signal transducer and activator of transcription 5A isoform 1

    See identical proteins and their annotated locations for NP_035618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AA718536, AK134012, AY299491, BY277646
    Consensus CDS
    CCDS25439.1
    UniProtKB/Swiss-Prot
    P42230
    UniProtKB/TrEMBL
    Q3UZ79, Q9JIA0
    Related
    ENSMUSP00000004145.7, OTTMUSP00000002045, ENSMUST00000004145.13, OTTMUST00000004310
    Conserved Domains (4) summary
    cd10421
    Location:573 → 712
    SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
    pfam01017
    Location:141 → 330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332 → 582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    100859351..100885169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532722.1 → XP_006532785.1  signal transducer and activator of transcription 5A isoform X1

    UniProtKB/Swiss-Prot
    P42230
    UniProtKB/TrEMBL
    Q9JIA0
    Related
    ENSMUSP00000102979.1, OTTMUSP00000002046, ENSMUST00000107356.7, OTTMUST00000004311
    Conserved Domains (4) summary
    cd10421
    Location:573 → 712
    SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
    pfam01017
    Location:141 → 330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332 → 582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  2. XM_006532721.1 → XP_006532784.1  signal transducer and activator of transcription 5A isoform X1

    See identical proteins and their annotated locations for XP_006532784.1

    UniProtKB/Swiss-Prot
    P42230
    UniProtKB/TrEMBL
    Q9JIA0
    Conserved Domains (4) summary
    cd10421
    Location:573 → 712
    SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
    pfam01017
    Location:141 → 330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332 → 582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain

  3. XM_017314402.1 → XP_017169891.1  signal transducer and activator of transcription 5A isoform X1

    UniProtKB/Swiss-Prot
    P42230
    UniProtKB/TrEMBL
    Q9JIA0
    Conserved Domains (4) summary
    cd10421
    Location:573 → 712
    SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
    pfam01017
    Location:141 → 330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332 → 582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42230.1 GenPept UniProtKB/Swiss-Prot:P42230

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