Stat5a signal transducer and activator of transcription 5A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stat5aprovided by MGI
Official Full Name: signal transducer and activator of transcription 5Aprovided by MGI
Primary source: MGI:MGI:103036
See related: Ensembl:ENSMUSG00000004043
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: STA; STAT5; AA959963
Expression: Broad expression in thymus adult (RPKM 40.3), mammary gland adult (RPKM 29.6) and 20 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 D; 11 63.77 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100750177..100775995)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100859351..100885169)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	11	NC_000077.5 (100720665..100746483)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stat5a promotes brown adipocyte differentiation and thermogenic program through binding and transactivating the Kdm6a promoter.
Title: Stat5a promotes brown adipocyte differentiation and thermogenic program through binding and transactivating the Kdm6a promoter.
STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.
Title: STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.
STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.
Title: STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.
The neonatal microenvironment programs innate gammadelta T cells through the transcription factor STAT5.
Title: The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.
Signal transducer and activator of transcription 5a (STAT5a) represses mitochondrial gene expression through direct binding to mitochondrial DNA.
Title: Signal transducer and activator of transcription 5a (STAT5a) represses mitochondrial gene expression through direct binding to mitochondrial DNA.
A point mutation in the linker domain of mouse STAT5A is associated with impaired NK-cell regulation.
Title: A point mutation in the linker domain of mouse STAT5A is associated with impaired NK-cell regulation.
IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis.
Title: IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis.
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus.
Title: STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus.
B cell-Derived IL35 Drives STAT3-Dependent CD8(+) T-cell Exclusion in Pancreatic Cancer.
Title: B cell-Derived IL35 Drives STAT3-Dependent CD8<sup>+</sup> T-cell Exclusion in Pancreatic Cancer.
STAT5 ablation in AgRP neurons increases female adiposity and blunts food restriction adaptations.
Title: STAT5 ablation in AgRP neurons increases female adiposity and blunts food restriction adaptations.

Submit: New GeneRIF Correction See all GeneRIFs (287)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Stat5a (e-PCR), detects polymorphism
- UniSTS:547375

PMC303338P1 (e-PCR)
- UniSTS:272497

Stat5a (e-PCR), detects polymorphism
- UniSTS:144514

AA959963 (e-PCR)
- UniSTS:160158

fc25e01.x1 (e-PCR)
- UniSTS:187855

U21103 (e-PCR)
- UniSTS:125693

Homology

Homologs of the Stat5a gene: The Stat5a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and mosquito.
Orthologs from Annotation Pipeline: 55 organisms have orthologs with human gene Stat5a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables phosphate ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Peyer's patch development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell differentiation in thymus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within development of secondary female sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within development of secondary male sexual characteristics	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within development of secondary male sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female pregnancy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in growth hormone receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lactation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within luteinization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland epithelium development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mammary gland epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mammary gland involution	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within natural killer cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of mast cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of activated T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-2 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of lymphocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate gland epithelium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reelin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of steroid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription, DNA-templated	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within taurine metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: signal transducer and activator of transcription 5A

Names: mammary gland factor STAT5A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164062.1 → NP_001157534.1 signal transducer and activator of transcription 5A isoform 2

See identical proteins and their annotated locations for NP_001157534.1

Status: VALIDATED

Description

Transcript Variant: This variant (2), also known as delta E18, lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA718536, AK134012, BY277646, EU249543

Consensus CDS

CCDS48933.1

UniProtKB/TrEMBL

B2C3G8, Q3UZ79

Related

ENSMUSP00000102980.3, ENSMUST00000107357.4

Conserved Domains (4) summary

cd10421
Location:573 → 708

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

pfam01017
Location:141 → 330

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:332 → 582

STAT_bind; STAT protein, DNA binding domain

pfam02865
Location:2 → 124

STAT_int; STAT protein, protein interaction domain
NM_001362680.1 → NP_001349609.1 signal transducer and activator of transcription 5A isoform 1

Status: VALIDATED

Source sequence(s)

AL591466, BY478099

Consensus CDS

CCDS25439.1

Related

ENSMUSP00000102979.2, ENSMUST00000107356.8

Conserved Domains (4) summary

cd10421
Location:573 → 712

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:332 → 489

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:4 → 124

STAT_int; STAT protein, protein interaction domain
NM_011488.3 → NP_035618.1 signal transducer and activator of transcription 5A isoform 1

See identical proteins and their annotated locations for NP_035618.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).

Source sequence(s)

AA718536, AK134012, AY299491, BY277646

Consensus CDS

CCDS25439.1

UniProtKB/Swiss-Prot

P42230

UniProtKB/TrEMBL

Q3UZ79, Q9JIA0

Related

ENSMUSP00000004145.8, ENSMUST00000004145.14

Conserved Domains (4) summary

cd10421
Location:573 → 712

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:332 → 489

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:4 → 124

STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

100750177..100775995

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532721.3 → XP_006532784.1 signal transducer and activator of transcription 5A isoform X1

See identical proteins and their annotated locations for XP_006532784.1

UniProtKB/Swiss-Prot

P42230

UniProtKB/TrEMBL

Q9JIA0

Conserved Domains (4) summary

cd10421
Location:573 → 712

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:332 → 489

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:4 → 124

STAT_int; STAT protein, protein interaction domain
XM_017314402.3 → XP_017169891.1 signal transducer and activator of transcription 5A isoform X1

UniProtKB/Swiss-Prot

P42230

UniProtKB/TrEMBL

Q9JIA0

Conserved Domains (4) summary

cd10421
Location:573 → 712

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:332 → 489

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:4 → 124

STAT_int; STAT protein, protein interaction domain