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Stat5a signal transducer and activator of transcription 5A [ Mus musculus (house mouse) ]

Gene ID: 20850, updated on 8-Feb-2024

Summary

Official Symbol
Stat5aprovided by MGI
Official Full Name
signal transducer and activator of transcription 5Aprovided by MGI
Primary source
MGI:MGI:103036
See related
Ensembl:ENSMUSG00000004043 AllianceGenome:MGI:103036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STAT5
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and phosphate ion binding activity. Involved in growth hormone receptor signaling pathway via JAK-STAT and regulation of growth. Acts upstream of or within several processes, including animal organ development; positive regulation of leukocyte proliferation; and regulation of hemopoiesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human STAT5A (signal transducer and activator of transcription 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 40.3), mammary gland adult (RPKM 29.6) and 20 other tissues See more
Orthologs
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Genomic context

See Stat5a in Genome Data Viewer
Location:
11 D; 11 63.77 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100750177..100775995)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100859351..100885169)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5278 Neighboring gene STARR-positive B cell enhancer ABC_E8453 Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B Neighboring gene STARR-positive B cell enhancer ABC_E8454 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100681071-100681254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100707044-100707332 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100753050-100753254 Neighboring gene STARR-positive B cell enhancer ABC_E8455 Neighboring gene signal transducer and activator of transcription 3 Neighboring gene STARR-positive B cell enhancer ABC_E5279 Neighboring gene STARR-seq mESC enhancer starr_30745 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100800942-100801125 Neighboring gene predicted gene, 46295 Neighboring gene STARR-seq mESC enhancer starr_30746 Neighboring gene caveolae associated 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of B cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within Peyer's patch development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of activated T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within development of secondary female sexual characteristics IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within development of secondary male sexual characteristics IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within development of secondary male sexual characteristics IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eosinophil differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of erythrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within female pregnancy IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of gamma-delta T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in growth hormone receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-15-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of interleukin-2 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in interleukin-2-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-3-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-4-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-5-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-9-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid storage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within luteinization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of lymphocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland epithelium development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mammary gland involution ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mast cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mast cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mast cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of myeloid cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of erythrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of mast cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of activated T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-2 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of lymphocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reelin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of steroid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to peptide hormone IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect taurine metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal transducer and activator of transcription 5A
Names
mammary gland factor STAT5A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164062.2NP_001157534.1  signal transducer and activator of transcription 5A isoform 2

    See identical proteins and their annotated locations for NP_001157534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), also known as delta E18, lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL591466
    Consensus CDS
    CCDS48933.1
    UniProtKB/TrEMBL
    B2C3G8
    Related
    ENSMUSP00000102980.3, ENSMUST00000107357.4
    Conserved Domains (4) summary
    cd10421
    Location:573708
    SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
    cd16855
    Location:139330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:4124
    STAT_int; STAT protein, protein interaction domain
  2. NM_001362680.1NP_001349609.1  signal transducer and activator of transcription 5A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591466, BY478099
    Consensus CDS
    CCDS25439.1
    UniProtKB/Swiss-Prot
    P42230
    UniProtKB/TrEMBL
    Q9JIA0
    Related
    ENSMUSP00000102979.2, ENSMUST00000107356.8
    Conserved Domains (4) summary
    cd10421
    Location:573712
    SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
    cd16855
    Location:139330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:4124
    STAT_int; STAT protein, protein interaction domain
  3. NM_001425424.1NP_001412353.1  signal transducer and activator of transcription 5A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591466
    UniProtKB/Swiss-Prot
    P42230
    UniProtKB/TrEMBL
    Q9JIA0
  4. NM_001425425.1NP_001412354.1  signal transducer and activator of transcription 5A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591466
    UniProtKB/Swiss-Prot
    P42230
    UniProtKB/TrEMBL
    Q9JIA0
  5. NM_011488.3NP_035618.1  signal transducer and activator of transcription 5A isoform 1

    See identical proteins and their annotated locations for NP_035618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AA718536, AK134012, AY299491, BY277646
    Consensus CDS
    CCDS25439.1
    UniProtKB/Swiss-Prot
    P42230
    UniProtKB/TrEMBL
    Q9JIA0
    Related
    ENSMUSP00000004145.8, ENSMUST00000004145.14
    Conserved Domains (4) summary
    cd10421
    Location:573712
    SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
    cd16855
    Location:139330
    STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    cd16849
    Location:332489
    STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
    pfam02865
    Location:4124
    STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100750177..100775995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)