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Star steroidogenic acute regulatory protein [ Mus musculus (house mouse) ]

Gene ID: 20845, updated on 21-Mar-2023

Summary

Official Symbol
Starprovided by MGI
Official Full Name
steroidogenic acute regulatory proteinprovided by MGI
Primary source
MGI:MGI:102760
See related
Ensembl:ENSMUSG00000031574 AllianceGenome:MGI:102760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
stARD1; D8Ertd419e
Summary
Predicted to enable cholesterol binding activity. Acts upstream of or within cellular lipid metabolic process; glucocorticoid metabolic process; and regulation of steroid biosynthetic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland; extraembryonic component; and reproductive system. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward adrenal adult (RPKM 849.8) See more
Orthologs
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Genomic context

See Star in Genome Data Viewer
Location:
8 A2; 8 14.17 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26298502..26306010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25808474..25815982)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene BCL2-associated athanogene 4 Neighboring gene electron transferring flavoprotein, alpha polypeptide pseudogene Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene Star 5' regulatory region Neighboring gene ASH2 like histone lysine methyltransferase complex subunit Neighboring gene potassium channel, subfamily U, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol transfer activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
involved_in estrogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucocorticoid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of steroid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
steroidogenic acute regulatory protein, mitochondrial
Names
START domain-containing protein 1
luteinizing hormone-induced protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011485.5NP_035615.2  steroidogenic acute regulatory protein, mitochondrial precursor

    See identical proteins and their annotated locations for NP_035615.2

    Status: VALIDATED

    Source sequence(s)
    AK019725, AK054470, AK136327
    Consensus CDS
    CCDS22203.1
    UniProtKB/Swiss-Prot
    P51557, Q9D2G1
    Related
    ENSMUSP00000033979.5, ENSMUST00000033979.6
    Conserved Domains (1) summary
    cd08905
    Location:69277
    START_STARD1-like; Cholesterol-binding START domain of mammalian STARD1 and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26298502..26306010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)