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Sqle squalene epoxidase [ Mus musculus (house mouse) ]

Gene ID: 20775, updated on 8-Nov-2022

Summary

Official Symbol
Sqleprovided by MGI
Official Full Name
squalene epoxidaseprovided by MGI
Primary source
MGI:MGI:109296
See related
Ensembl:ENSMUSG00000022351 AllianceGenome:MGI:109296
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable FAD binding activity and squalene monooxygenase activity. Predicted to be involved in several processes, including lipid droplet formation; regulation of cell population proliferation; and sterol metabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human SQLE (squalene epoxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 52.8), whole brain E14.5 (RPKM 35.8) and 26 other tissues See more
Orthologs
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Genomic context

See Sqle in Genome Data Viewer
Location:
15; 15 D1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (59186941..59203042)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (59315092..59331193)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36617 Neighboring gene zinc finger protein 572 Neighboring gene WASH complex subunit 5 Neighboring gene NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables squalene monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables squalene monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular aromatic compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
squalene monooxygenase
Names
SE
NP_033296.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009270.3NP_033296.1  squalene monooxygenase

    See identical proteins and their annotated locations for NP_033296.1

    Status: PROVISIONAL

    Source sequence(s)
    AC113269
    Consensus CDS
    CCDS27497.1
    UniProtKB/Swiss-Prot
    P52019
    UniProtKB/TrEMBL
    Q3TQK8
    Related
    ENSMUSP00000022977.8, ENSMUST00000022977.14
    Conserved Domains (2) summary
    COG0654
    Location:123497
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    cl21454
    Location:275546
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    59186941..59203042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)