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Spint2 serine protease inhibitor, Kunitz type 2 [ Mus musculus (house mouse) ]

Gene ID: 20733, updated on 12-May-2024

Summary

Official Symbol
Spint2provided by MGI
Official Full Name
serine protease inhibitor, Kunitz type 2provided by MGI
Primary source
MGI:MGI:1338031
See related
Ensembl:ENSMUSG00000074227 AllianceGenome:MGI:1338031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HAI-2
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within basement membrane organization; chordate embryonic development; and establishment or maintenance of cell polarity. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 448.1), duodenum adult (RPKM 435.7) and 13 other tissues See more
Orthologs
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Genomic context

See Spint2 in Genome Data Viewer
Location:
7 B1; 7 16.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28955755..28981484, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29256330..29282059, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily K, member 6 Neighboring gene STARR-positive B cell enhancer ABC_E544 Neighboring gene Yip1 interacting factor homolog B (S. cerevisiae) Neighboring gene RIKEN cDNA 2200002D01 gene Neighboring gene predicted gene, 45977 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kunitz-type protease inhibitor 2
Names
hepatocyte growth factor activator inhibitor type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082548.1NP_001076017.1  kunitz-type protease inhibitor 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001076017.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AI227451, AK007792, BQ174562, CB196296
    Consensus CDS
    CCDS39869.1
    UniProtKB/TrEMBL
    Q9D8Q8
    Related
    ENSMUSP00000103871.4, ENSMUST00000108236.5
    Conserved Domains (1) summary
    cd00109
    Location:80126
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
  2. NM_011464.2NP_035594.1  kunitz-type protease inhibitor 2 isoform a precursor

    See identical proteins and their annotated locations for NP_035594.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AI227451, AK007792, BQ174562, CB196296
    Consensus CDS
    CCDS39870.1
    UniProtKB/Swiss-Prot
    Q5D0F2, Q9WU03, Q9WU04, Q9WU05
    Related
    ENSMUSP00000096204.5, ENSMUST00000098604.12
    Conserved Domains (2) summary
    cd00109
    Location:137183
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:3888
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28955755..28981484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322072.3XP_017177561.1  kunitz-type protease inhibitor 2 isoform X1

    Conserved Domains (1) summary
    pfam00014
    Location:3888
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain