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Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 [ Mus musculus (house mouse) ]

Gene ID: 20720, updated on 5-Mar-2024

Summary

Official Symbol
Serpine2provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade E, member 2provided by MGI
Primary source
MGI:MGI:101780
See related
Ensembl:ENSMUSG00000026249 AllianceGenome:MGI:101780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PI7; PI-7; PN-1; Spi4; PAI-1; B230326M24Rik
Summary
Enables serine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in negative regulation of plasminogen activation and negative regulation of platelet aggregation. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and negative regulation of signal transduction. Located in extracellular region and neuromuscular junction. Is expressed in several structures, including alimentary system; central nervous system; limb; musculoskeletal system; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 75.8), frontal lobe adult (RPKM 44.2) and 16 other tissues See more
Orthologs
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Genomic context

See Serpine2 in Genome Data Viewer
Location:
1 C4; 1 40.97 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (79772038..79836382, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (79794317..79858665, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene WD repeat and FYVE domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:79772314-79772614 Neighboring gene mitochondrial ribosomal protein L44 Neighboring gene predicted gene, 39666 Neighboring gene STARR-seq mESC enhancer starr_01448 Neighboring gene STARR-seq mESC enhancer starr_01449 Neighboring gene STARR-seq mESC enhancer starr_01450 Neighboring gene STARR-seq mESC enhancer starr_01451 Neighboring gene solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 pseudogene Neighboring gene protein RTF2 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebellar granular layer morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dense core granule biogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mating plug formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of plasminogen activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of plasminogen activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein processing IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of sodium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of timing of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within secretion by cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within secretion by cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within secretory granule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within secretory granule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in secretory granule organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within seminal vesicle epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glia-derived nexin
Names
GDN
peptidase inhibitor 7
protease nexin 1
protease nexin I
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
serine (or cysteine) proteinase inhibitor, clade E, member 2
serine protease-inhibitor 4
serpin E2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009255.4NP_033281.1  glia-derived nexin precursor

    See identical proteins and their annotated locations for NP_033281.1

    Status: VALIDATED

    Source sequence(s)
    AK051332, BM899460, BY065983
    Consensus CDS
    CCDS15092.1
    UniProtKB/Swiss-Prot
    Q07235, Q921T7
    UniProtKB/TrEMBL
    Q3TWH7, Q4FJU1, Q543R5
    Related
    ENSMUSP00000027467.5, ENSMUST00000027467.11
    Conserved Domains (1) summary
    cd19573
    Location:21395
    serpinE2_GDN; serpin family E member 2, glia derived nexin (GDN)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    79772038..79836382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496459.5XP_006496522.1  glia-derived nexin isoform X1

    See identical proteins and their annotated locations for XP_006496522.1

    UniProtKB/Swiss-Prot
    Q07235, Q921T7
    UniProtKB/TrEMBL
    Q3TWH7, Q4FJU1, Q543R5
    Conserved Domains (1) summary
    cd19573
    Location:21395
    serpinE2_GDN; serpin family E member 2, glia derived nexin (GDN)