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DHRSX dehydrogenase/reductase X-linked [ Homo sapiens (human) ]

Gene ID: 207063, updated on 23-Nov-2021

Summary

Official Symbol
DHRSXprovided by HGNC
Official Full Name
dehydrogenase/reductase X-linkedprovided by HGNC
Primary source
HGNC:HGNC:18399
See related
Ensembl:ENSG00000169084 MIM:301034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHRSY; DHRS5X; DHRS5Y; DHRSXY; SDR7C6; CXorf11; SDR46C1
Expression
Ubiquitous expression in kidney (RPKM 6.0), liver (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See DHRSX in Genome Data Viewer
Location:
Xp22.33 and Yp11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (2219506..2500976, complement)
109.20211119 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (2219506..2500976, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (2137547..2419017, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (2087547..2369017, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379413 Neighboring gene uncharacterized LOC107985677 Neighboring gene uncharacterized LOC101928092 Neighboring gene zinc finger BED-type containing 1 Neighboring gene microRNA 6089

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379413 Neighboring gene uncharacterized LOC107985677 Neighboring gene uncharacterized LOC101928092 Neighboring gene zinc finger BED-type containing 1 Neighboring gene microRNA 6089

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member on chromosome X
Names
dehydrogenase/reductase (SDR family) X chromosome
dehydrogenase/reductase (SDR family) X-linked
dehydrogenase/reductase (SDR family) Y-linked
short chain dehydrogenase/reductase family 46C member 1
short chain dehydrogenase/reductase family 7C member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145177.3NP_660160.2  dehydrogenase/reductase SDR family member on chromosome X

    See identical proteins and their annotated locations for NP_660160.2

    Status: VALIDATED

    Source sequence(s)
    AC079176, AJ293620, BG703185, BM794858, CR856018
    Consensus CDS
    CCDS35195.1
    UniProtKB/Swiss-Prot
    Q8N5I4
    Related
    ENSP00000334113.5, ENST00000334651.11
    Conserved Domains (2) summary
    cd05327
    Location:43316
    retinol-DH_like_SDR_c_like; retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs
    PRK06197
    Location:39325
    PRK06197; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    2219506..2500976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    2219506..2500976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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