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Sphk1 sphingosine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 20698, updated on 22-Jan-2023

Summary

Official Symbol
Sphk1provided by MGI
Official Full Name
sphingosine kinase 1provided by MGI
Primary source
MGI:MGI:1316649
See related
Ensembl:ENSMUSG00000061878 AllianceGenome:MGI:1316649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sk1; Spk1; 1110006G24Rik
Summary
This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Expression
Broad expression in lung adult (RPKM 8.3), duodenum adult (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See Sphk1 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116421662..116427502)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116530836..116536675)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 1 Neighboring gene ribosomal protein L36, pseudogene 1 Neighboring gene ubiquitin-conjugating enzyme E2O Neighboring gene arylalkylamine N-acetyltransferase Neighboring gene rhomboid 5 homolog 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables D-erythro-sphingosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables D-erythro-sphingosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables D-erythro-sphingosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables sphinganine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sphinganine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables sphingosine-1-phosphate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cyclooxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endosomal vesicle fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microglial cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sphingolipid mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sphingosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sphingosine kinase 1
Names
acetyltransferase SPHK1
NP_001165943.1
NP_001165944.1
NP_001165946.1
NP_001359413.1
NP_001359414.1
NP_001359415.1
NP_001359416.1
NP_001359417.1
NP_001359418.1
NP_079643.2
XP_006532732.1
XP_006532735.1
XP_017169887.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172472.2NP_001165943.1  sphingosine kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001165943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2, 3 and 4 encode the same protein (isoform 2). This isoform is also known as Sphk1a2.
    Source sequence(s)
    AL645851
    Consensus CDS
    CCDS25668.1
    UniProtKB/Swiss-Prot
    Q8CI15, Q91ZN3
    Related
    ENSMUSP00000101994.2, ENSMUST00000106386.8
    Conserved Domains (1) summary
    PLN02958
    Location:11344
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  2. NM_001172473.1NP_001165944.1  sphingosine kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001165944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2, 3 and 4 encode the same protein (isoform 2). This isoform is also known as Sphk1a2.
    Source sequence(s)
    AK160900, AL645851
    Consensus CDS
    CCDS25668.1
    UniProtKB/Swiss-Prot
    Q8CI15, Q91ZN3
    Conserved Domains (1) summary
    PLN02958
    Location:11344
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  3. NM_001172475.1NP_001165946.1  sphingosine kinase 1 isoform 3

    See identical proteins and their annotated locations for NP_001165946.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1. This isoform is also known as Sphk1a.
    Source sequence(s)
    AL645851
    Consensus CDS
    CCDS48986.1
    UniProtKB/Swiss-Prot
    Q8CI15
    Related
    ENSMUSP00000097775.4, ENSMUST00000100201.10
    Conserved Domains (1) summary
    PLN02958
    Location:10343
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  4. NM_001372484.1NP_001359413.1  sphingosine kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL645851
    Consensus CDS
    CCDS25668.1
    UniProtKB/Swiss-Prot
    Q91ZN3
    Related
    ENSMUSP00000101996.3, ENSMUST00000106388.9
    Conserved Domains (1) summary
    PLN02958
    Location:11344
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  5. NM_001372485.1NP_001359414.1  sphingosine kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL645851
    Conserved Domains (1) summary
    PLN02958
    Location:1267
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  6. NM_001372486.1NP_001359415.1  sphingosine kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL645851
    Consensus CDS
    CCDS25668.1
    UniProtKB/Swiss-Prot
    Q91ZN3
    Related
    ENSMUSP00000101995.3, ENSMUST00000106387.9
    Conserved Domains (1) summary
    PLN02958
    Location:11344
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  7. NM_001372487.1NP_001359416.1  sphingosine kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL645851
    Conserved Domains (1) summary
    PLN02958
    Location:1267
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  8. NM_001372488.1NP_001359417.1  sphingosine kinase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL645851
    Consensus CDS
    CCDS48986.1
    Conserved Domains (1) summary
    PLN02958
    Location:10343
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  9. NM_001372489.1NP_001359418.1  sphingosine kinase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL645851
    Consensus CDS
    CCDS48986.1
    Conserved Domains (1) summary
    PLN02958
    Location:10343
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  10. NM_025367.7NP_079643.2  sphingosine kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_079643.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2, 3 and 4 encode the same protein (isoform 2). This isoform is also known as Sphk1a2.
    Source sequence(s)
    AL645851
    Consensus CDS
    CCDS25668.1
    UniProtKB/Swiss-Prot
    Q8CI15, Q91ZN3
    Related
    ENSMUSP00000067865.7, ENSMUST00000063446.13
    Conserved Domains (1) summary
    PLN02958
    Location:11344
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116421662..116427502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532672.4XP_006532735.1  sphingosine kinase 1 isoform X3

    See identical proteins and their annotated locations for XP_006532735.1

    UniProtKB/Swiss-Prot
    Q8CI15
    Conserved Domains (1) summary
    PLN02958
    Location:10343
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  2. XM_006532669.5XP_006532732.1  sphingosine kinase 1 isoform X2

    Conserved Domains (1) summary
    PLN02958
    Location:140473
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  3. XM_017314398.2XP_017169887.1  sphingosine kinase 1 isoform X1

    Conserved Domains (1) summary
    PLN02958
    Location:141474
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011451.3: Suppressed sequence

    Description
    NM_011451.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.