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Son Son DNA binding protein [ Mus musculus (house mouse) ]

Gene ID: 20658, updated on 2-Oct-2018

Summary

Official Symbol
Sonprovided by MGI
Official Full Name
Son DNA binding proteinprovided by MGI
Primary source
MGI:MGI:98353
See related
Ensembl:ENSMUSG00000022961 Vega:OTTMUSG00000028340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nrebp; C81487; AA409051; AU067731; mKIAA1019; 2900011L12Rik
Expression
Ubiquitous expression in thymus adult (RPKM 48.2), ovary adult (RPKM 44.8) and 28 other tissues See more
Orthologs

Genomic context

See Son in Genome Data Viewer
Location:
16 C3.3-C4; 16 53.22 cM
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (91647824..91679195)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (91648069..91679437)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene phosphoribosylglycinamide formyltransferase Neighboring gene predicted gene, 36712 Neighboring gene downstream neighbor of SON Neighboring gene predicted gene 10785 Neighboring gene crystallin, zeta (quinone reductase)-like 1 Neighboring gene predicted gene, 46543

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding ISO
Inferred from Sequence Orthology
more info
 
RS domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA processing ISO
Inferred from Sequence Orthology
more info
 
microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein SON
Names
NRE-binding protein
Son cell proliferation protein
negative regulatory element-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019973.2NP_064357.2  protein SON isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC131691, AK040621, BC061113, BG229132, CJ088081
    Consensus CDS
    CCDS37400.1
    UniProtKB/TrEMBL
    Q8C9T5
    Related
    ENSMUSP00000109670.2, OTTMUSP00000035761, ENSMUST00000114036.8, OTTMUST00000070237
    Conserved Domains (1) summary
    pfam08430
    Location:10111137
    Forkhead_N; Forkhead N-terminal region
  2. NM_178880.4NP_849211.3  protein SON isoform 1

    See identical proteins and their annotated locations for NP_849211.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131691, AK040621, AK122418, BC061113, CB849818, CJ088081
    Consensus CDS
    CCDS37399.1
    UniProtKB/Swiss-Prot
    Q9QX47
    UniProtKB/TrEMBL
    Q80TM4, Q8C9T5
    Related
    ENSMUSP00000109671.2, OTTMUSP00000045712, ENSMUST00000114037.8, OTTMUST00000084749
    Conserved Domains (3) summary
    cd00048
    Location:23892426
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam08430
    Location:10111137
    Forkhead_N; Forkhead N-terminal region
    pfam01585
    Location:23232366
    G-patch; G-patch domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    91647824..91679195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522973.2XP_006523036.1  protein SON isoform X2

    UniProtKB/TrEMBL
    H9KV01
    Related
    ENSMUSP00000113129.1, OTTMUSP00000035762, ENSMUST00000119368.7, OTTMUST00000070238
    Conserved Domains (1) summary
    pfam08430
    Location:10111137
    Forkhead_N; Forkhead N-terminal region
  2. XM_006522969.3XP_006523032.1  protein SON isoform X1

    UniProtKB/TrEMBL
    H9KV00
    Related
    ENSMUSP00000112453.1, OTTMUSP00000035760, ENSMUST00000117633.7, OTTMUST00000070236
    Conserved Domains (3) summary
    smart00358
    Location:23902458
    DSRM; Double-stranded RNA binding motif
    pfam08430
    Location:10111137
    Forkhead_N; Forkhead N-terminal region
    pfam01585
    Location:23232366
    G-patch; G-patch domain
  3. XM_011246108.2XP_011244410.1  protein SON isoform X3

    Conserved Domains (3) summary
    smart00358
    Location:20412109
    DSRM; Double-stranded RNA binding motif
    pfam08430
    Location:662788
    Forkhead_N; Forkhead N-terminal region
    pfam01585
    Location:19742017
    G-patch; G-patch domain

RNA

  1. XR_384932.3 RNA Sequence

  2. XR_001781801.1 RNA Sequence

  3. XR_001781802.1 RNA Sequence

  4. XR_001781804.1 RNA Sequence

  5. XR_001781803.1 RNA Sequence

  6. XR_001781805.1 RNA Sequence

  7. XR_001781797.1 RNA Sequence

  8. XR_001781798.1 RNA Sequence

  9. XR_001781799.1 RNA Sequence

  10. XR_001781800.1 RNA Sequence

    Related
    ENSMUST00000140312.7, OTTMUST00000070240
  11. XR_384935.3 RNA Sequence

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