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Sod2 superoxide dismutase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 20656, updated on 1-Mar-2024

Summary

Official Symbol
Sod2provided by MGI
Official Full Name
superoxide dismutase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:98352
See related
Ensembl:ENSMUSG00000006818 AllianceGenome:MGI:98352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MnSOD; Sod-2
Summary
Enables superoxide dismutase activity. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and regulation of cellular biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Canavan disease; Leigh disease; amyotrophic lateral sclerosis type 1; congestive heart failure; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 82.2), adrenal adult (RPKM 81.7) and 28 other tissues See more
Orthologs
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Genomic context

See Sod2 in Genome Data Viewer
Location:
17 A1; 17 8.75 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13226726..13237006)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (13007839..13018119)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15946 Neighboring gene WT1 associating protein Neighboring gene STARR-seq mESC enhancer starr_41863 Neighboring gene STARR-seq mESC enhancer starr_41864 Neighboring gene STARR-positive B cell enhancer ABC_E7488 Neighboring gene STARR-positive B cell enhancer ABC_E10934 Neighboring gene STARR-positive B cell enhancer ABC_E10935 Neighboring gene predicted gene, 36117 Neighboring gene G protein-coupled receptor 31, D17Leh66b region

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6144

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables superoxide dismutase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables superoxide dismutase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic mitochondrial changes IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within detection of oxygen IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrophore differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hydrogen peroxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular oxygen homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within removal of superoxide radicals IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within respiratory electron transport chain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to gamma radiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hyperoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to superoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to superoxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
superoxide dismutase [Mn], mitochondrial
Names
manganese SOD
manganese superoxide dismutase
NP_038699.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013671.3NP_038699.2  superoxide dismutase [Mn], mitochondrial precursor

    See identical proteins and their annotated locations for NP_038699.2

    Status: VALIDATED

    Source sequence(s)
    AK135435, AL589878, BY137511
    Consensus CDS
    CCDS28399.1
    UniProtKB/Swiss-Prot
    P09671, Q64670, Q8VEM5
    UniProtKB/TrEMBL
    Q3TJA2, Q3U8W4, Q4FJX9
    Related
    ENSMUSP00000007012.5, ENSMUST00000007012.6
    Conserved Domains (3) summary
    COG0605
    Location:25222
    SodA; Superoxide dismutase [Inorganic ion transport and metabolism]
    pfam00081
    Location:25106
    Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
    pfam02777
    Location:113216
    Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    13226726..13237006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)