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Snrpb2 U2 small nuclear ribonucleoprotein B [ Mus musculus (house mouse) ]

Gene ID: 20639, updated on 2-Nov-2024

Summary

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Official Symbol
Snrpb2provided by MGI
Official Full Name
U2 small nuclear ribonucleoprotein Bprovided by MGI
Primary source
MGI:MGI:104805
See related
Ensembl:ENSMUSG00000008333 AllianceGenome:MGI:104805
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810052G09Rik
Summary
Predicted to enable U1 snRNA binding activity and snRNP binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytoplasmic ribonucleoprotein granule; fibrillar center; and nuclear speck. Predicted to be part of U1 snRNP; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Is expressed in 8-cell stage embryo; central nervous system; olfactory epithelium; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 38.4), CNS E14 (RPKM 22.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Snrpb2 in Genome Data Viewer
Location:
2 G1; 2 70.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (142904989..142913972)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (143063069..143072052)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kinesin family member 16B Neighboring gene STARR-seq mESC enhancer starr_05876 Neighboring gene STARR-positive B cell enhancer mm9_chr2:142638896-142639197 Neighboring gene predicted gene, 22310 Neighboring gene STARR-positive B cell enhancer ABC_E5991 Neighboring gene STARR-positive B cell enhancer ABC_E4505 Neighboring gene STARR-positive B cell enhancer ABC_E2049 Neighboring gene kinesin family member 16B, opposite strand Neighboring gene STARR-seq mESC enhancer starr_05877 Neighboring gene STARR-positive B cell enhancer ABC_E3408 Neighboring gene STARR-seq mESC enhancer starr_05878 Neighboring gene STARR-seq mESC enhancer starr_05879 Neighboring gene otoraplin Neighboring gene predicted gene 14083

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. U2-snRNP B" protein gene is an early growth-inducible gene. Laitinen J, et al. J Cell Biochem, 1995 Aug. PMID 7593271
  2. Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation. Matsuoka T, et al. J Reprod Dev, 2008 Jun. PMID 18360097
  3. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. Tucker KE, et al. J Cell Biol, 2001 Jul 23. PMID 11470819, Free PMC Article
  4. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Chiu S, et al. Physiol Genomics, 2007 Sep 19. PMID 17536020
  5. The biogenesis of the coiled body during early mouse development. Ferreira J, et al. Development, 1995 Feb. PMID 7768196

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables snRNP binding IEA
Inferred from Electronic Annotation
more info
  
enables snRNP binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type catalytic step 2 spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of U2-type precatalytic spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic ribonucleoprotein granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of small nuclear ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U2 small nuclear ribonucleoprotein B''
Names
U2 snRNP B''

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021335.3 → NP_067310.1  U2 small nuclear ribonucleoprotein B''

    See identical proteins and their annotated locations for NP_067310.1

    Status: PROVISIONAL

    Source sequence(s)
    AK013871
    Consensus CDS
    CCDS16808.1
    UniProtKB/Swiss-Prot
    Q9CQI7, Q9CW35, Q9CZ66
    Related
    ENSMUSP00000008477.7, ENSMUST00000008477.13
    Conserved Domains (2) summary
    cd12478
    Location:6 → 96
    RRM1_U2B; RNA recognition motif 1 in U2 small nuclear ribonucleoprotein B" (U2B") and similar proteins
    cd12481
    Location:146 → 225
    RRM2_U2B; RNA recognition motif 2 found in vertebrate U2 small nuclear ribonucleoprotein B" (U2B")

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    142904989..142913972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQI7.1 GenPept UniProtKB/Swiss-Prot:Q9CQI7

Gene LinkOut

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