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SLC36A1 solute carrier family 36 member 1 [ Homo sapiens (human) ]

Gene ID: 206358, updated on 2-Nov-2024

Summary

Official Symbol
SLC36A1provided by HGNC
Official Full Name
solute carrier family 36 member 1provided by HGNC
Primary source
HGNC:HGNC:18761
See related
Ensembl:ENSG00000123643 MIM:606561; AllianceGenome:HGNC:18761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Dct1; PAT1; LYAAT1; TRAMD3
Summary
This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Broad expression in duodenum (RPKM 7.4), small intestine (RPKM 6.6) and 20 other tissues See more
Orthologs
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Genomic context

See SLC36A1 in Genome Data Viewer
Location:
5q33.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (151344596..151556085)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (151883565..152095073)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150816607..150871940)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23456 Neighboring gene solute carrier family 36 member 3 Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 5 Neighboring gene solute carrier family 36 member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:150726633-150727546 Neighboring gene uncharacterized LOC105378234 Neighboring gene mediator complex subunit 13 pseudogene Neighboring gene RUN domain containing 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:150767117-150768055 Neighboring gene NANOG-H3K4me1 hESC enhancers GRCh37_chr5:150804400-150804900 and GRCh37_chr5:150804901-150805401 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:150816347-150816517 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23457 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82502 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82529 Neighboring gene RNA, 5S ribosomal pseudogene 197 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:150875552-150876101 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:150877439-150878100 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82540 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82543 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82555 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82563 Neighboring gene microRNA 6499 Neighboring gene FAT atypical cadherin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:150950930-150951442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:150974668-150975189 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:150998970-150999648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:150999649-151000325 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:151003759-151004958 Neighboring gene uncharacterized LOC105378231 Neighboring gene uncharacterized LOC124901116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23460 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:151042798-151043997 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:151063929-151064758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:151065587-151066416 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:151066417-151067244 Neighboring gene secreted protein acidic and cysteine rich Neighboring gene colorectal liver metastasis associated transcript 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-proline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
enables amino acid:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amino acid:proton symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables proline:proton symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables taurine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in L-alanine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in alanine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amino acid import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amino acid transport TAS
Traceable Author Statement
more info
 
involved_in glycine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic ion transport TAS
Traceable Author Statement
more info
 
involved_in proline transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proline transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in taurine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in lysosomal membrane HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
proton-coupled amino acid transporter 1
Names
lysosomal amino acid transporter 1
proton/amino acid transporter 1
solute carrier family 36 (proton/amino acid symporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308150.2NP_001295079.1  proton-coupled amino acid transporter 1 isoform b

    See identical proteins and their annotated locations for NP_001295079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a shorter 3' coding region and alternate 3' UTR, compared to variant 1. The encoded isoform (b) is shorter at the C-terminus, compared to isoform a.
    Source sequence(s)
    AY162213, AY227111, BM787446
    Consensus CDS
    CCDS83035.1
    UniProtKB/TrEMBL
    E7EW39
    Related
    ENSP00000430305.1, ENST00000521925.5
    Conserved Domains (1) summary
    cl00456
    Location:47386
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_001308151.2NP_001295080.1  proton-coupled amino acid transporter 1 isoform c

    See identical proteins and their annotated locations for NP_001295080.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, and it also lacks several 3' exons but contains alternate 3' exon structure, thereby differing in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK057340, AY227113
    Consensus CDS
    CCDS78073.1
    Related
    ENSP00000395640.2, ENST00000429484.6
    Conserved Domains (1) summary
    cl00456
    Location:47243
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. NM_001349740.2NP_001336669.1  proton-coupled amino acid transporter 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in its 5' coding region, resulting in use of an alternate start codon, and a longer 5' UTR, compared to variant 1. The encoded isoform (d) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC034205, AL833703, AY162213, BC136438, BM787446
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:52425
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. NM_078483.4NP_510968.2  proton-coupled amino acid transporter 1 isoform a

    See identical proteins and their annotated locations for NP_510968.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL833703, AY162213, BC136438, BM787446
    Consensus CDS
    CCDS4316.1
    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Related
    ENSP00000243389.3, ENST00000243389.8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    151344596..151556085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537591.2XP_011535893.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535893.1

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_047416924.1XP_047272880.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  3. XM_011537585.1XP_011535887.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535887.1

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Related
    ENSP00000428140.1, ENST00000520701.5
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_017009217.2XP_016864706.1  proton-coupled amino acid transporter 1 isoform X7

    UniProtKB/TrEMBL
    E7EW39
  5. XM_011537581.2XP_011535883.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535883.1

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  6. XM_047416923.1XP_047272879.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  7. XM_011537590.2XP_011535892.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535892.1

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  8. XM_011537587.4XP_011535889.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535889.1

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  9. XM_011537584.3XP_011535886.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535886.1

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  10. XM_011537592.3XP_011535894.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535894.1

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  11. XM_011537580.3XP_011535882.1  proton-coupled amino acid transporter 1 isoform X2

    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:53459
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  12. XM_011537589.4XP_011535891.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535891.1

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  13. XM_047416928.1XP_047272884.1  proton-coupled amino acid transporter 1 isoform X8

  14. XM_011537586.3XP_011535888.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535888.1

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  15. XM_017009216.2XP_016864705.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  16. XM_047416921.1XP_047272877.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  17. XM_047416925.1XP_047272881.1  proton-coupled amino acid transporter 1 isoform X4

  18. XM_011537595.3XP_011535897.3  proton-coupled amino acid transporter 1 isoform X5

  19. XM_047416920.1XP_047272876.1  proton-coupled amino acid transporter 1 isoform X1

  20. XM_047416927.1XP_047272883.1  proton-coupled amino acid transporter 1 isoform X6

  21. XM_011537596.3XP_011535898.3  proton-coupled amino acid transporter 1 isoform X10

  22. XM_047416929.1XP_047272885.1  proton-coupled amino acid transporter 1 isoform X11

  23. XM_006714759.5XP_006714822.1  proton-coupled amino acid transporter 1 isoform X9

    UniProtKB/TrEMBL
    D2Y3F6
    Conserved Domains (1) summary
    cl00456
    Location:2375
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    151883565..152095073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352033.1XP_054208008.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  2. XM_054352036.1XP_054208011.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  3. XM_054352027.1XP_054208002.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  4. XM_054352030.1XP_054208005.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  5. XM_054352040.1XP_054208015.1  proton-coupled amino acid transporter 1 isoform X7

  6. XM_054352025.1XP_054208000.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  7. XM_054352043.1XP_054208018.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  8. XM_054352031.1XP_054208006.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  9. XM_054352032.1XP_054208007.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  10. XM_054352034.1XP_054208009.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  11. XM_054352029.1XP_054208004.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  12. XM_054352028.1XP_054208003.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  13. XM_054352024.1XP_054207999.1  proton-coupled amino acid transporter 1 isoform X2

  14. XM_054352041.1XP_054208016.1  proton-coupled amino acid transporter 1 isoform X8

  15. XM_054352035.1XP_054208010.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  16. XM_054352026.1XP_054208001.1  proton-coupled amino acid transporter 1 isoform X3

    UniProtKB/Swiss-Prot
    C9JI34, Q1LZ56, Q7Z2H8, Q7Z7C0, Q86YK4, Q96M74
  17. XM_054352037.1XP_054208012.1  proton-coupled amino acid transporter 1 isoform X4

  18. XM_054352038.1XP_054208013.1  proton-coupled amino acid transporter 1 isoform X5

  19. XM_054352023.1XP_054207998.1  proton-coupled amino acid transporter 1 isoform X1

  20. XM_054352039.1XP_054208014.1  proton-coupled amino acid transporter 1 isoform X6

  21. XM_054352044.1XP_054208019.1  proton-coupled amino acid transporter 1 isoform X10

  22. XM_054352045.1XP_054208020.1  proton-coupled amino acid transporter 1 isoform X11

  23. XM_054352042.1XP_054208017.1  proton-coupled amino acid transporter 1 isoform X9