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SLC36A1 solute carrier family 36 member 1 [ Homo sapiens (human) ]

Gene ID: 206358, updated on 21-Dec-2019

Summary

Official Symbol
SLC36A1provided by HGNC
Official Full Name
solute carrier family 36 member 1provided by HGNC
Primary source
HGNC:HGNC:18761
See related
Ensembl:ENSG00000123643 MIM:606561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Dct1; PAT1; LYAAT1; TRAMD3
Summary
This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Broad expression in duodenum (RPKM 7.4), small intestine (RPKM 6.6) and 20 other tissues See more
Orthologs

Genomic context

See SLC36A1 in Genome Data Viewer
Location:
5q33.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (151411344..151556318)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150816553..150871940)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378234 Neighboring gene mediator complex subunit 13 pseudogene Neighboring gene RUN domain containing 1 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 197 Neighboring gene FAT atypical cadherin 2 Neighboring gene microRNA 6499 Neighboring gene uncharacterized LOC105378231 Neighboring gene secreted protein acidic and cysteine rich Neighboring gene colorectal liver metastasis associated transcript 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-proline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
amino acid:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proton transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
L-alanine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transport TAS
Traceable Author Statement
more info
 
glycine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transport TAS
Traceable Author Statement
more info
 
proline transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
proton-coupled amino acid transporter 1
Names
lysosomal amino acid transporter 1
proton/amino acid transporter 1
solute carrier family 36 (proton/amino acid symporter), member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308150.2NP_001295079.1  proton-coupled amino acid transporter 1 isoform b

    See identical proteins and their annotated locations for NP_001295079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a shorter 3' coding region and alternate 3' UTR, compared to variant 1. The encoded isoform (b) is shorter at the C-terminus, compared to isoform a.
    Source sequence(s)
    AY162213, AY227111, BM787446
    Consensus CDS
    CCDS83035.1
    UniProtKB/Swiss-Prot
    Q7Z2H8
    Related
    ENSP00000480948.1, ENST00000616007.4
    Conserved Domains (1) summary
    cl00456
    Location:47386
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_001308151.2NP_001295080.1  proton-coupled amino acid transporter 1 isoform c

    See identical proteins and their annotated locations for NP_001295080.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, and it also lacks several 3' exons but contains alternate 3' exon structure, thereby differing in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK057340, AY227113
    Consensus CDS
    CCDS78073.1
    UniProtKB/Swiss-Prot
    Q7Z2H8
    Related
    ENSP00000395640.2, ENST00000429484.6
    Conserved Domains (1) summary
    cl00456
    Location:47243
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. NM_001349740.2NP_001336669.1  proton-coupled amino acid transporter 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in its 5' coding region, resulting in use of an alternate start codon, and a longer 5' UTR, compared to variant 1. The encoded isoform (d) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC034205, AL833703, AY162213, BC136438, BM787446
    Conserved Domains (1) summary
    cl00456
    Location:52425
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. NM_078483.4NP_510968.2  proton-coupled amino acid transporter 1 isoform a

    See identical proteins and their annotated locations for NP_510968.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL833703, AY162213, BC136438, BM787446
    Consensus CDS
    CCDS4316.1
    UniProtKB/Swiss-Prot
    Q7Z2H8
    Related
    ENSP00000243389.3, ENST00000243389.8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    151411344..151556318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537591.1XP_011535893.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535893.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_005268386.1XP_005268443.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_005268443.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Related
    ENSP00000428140.1, ENST00000520701.5
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. XM_017009220.1XP_016864709.1  proton-coupled amino acid transporter 1 isoform X11

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47243
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_011537585.1XP_011535887.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535887.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. XM_024454398.1XP_024310166.1  proton-coupled amino acid transporter 1 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:52425
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  6. XM_024446001.1XP_024301769.1  proton-coupled amino acid transporter 1 isoform X6

    Conserved Domains (1) summary
    cl00456
    Location:47358
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  7. XM_017009219.2XP_016864708.1  proton-coupled amino acid transporter 1 isoform X9

  8. XM_011537583.3XP_011535885.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535885.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  9. XM_011537589.3XP_011535891.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535891.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  10. XM_024454399.1XP_024310167.1  proton-coupled amino acid transporter 1 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:52425
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  11. XM_011537587.3XP_011535889.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535889.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  12. XM_006714759.4XP_006714822.1  proton-coupled amino acid transporter 1 isoform X7

    Conserved Domains (1) summary
    cl00456
    Location:2375
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  13. XM_017009217.1XP_016864706.1  proton-coupled amino acid transporter 1 isoform X5

  14. XM_011537594.1XP_011535896.1  proton-coupled amino acid transporter 1 isoform X3

    See identical proteins and their annotated locations for XP_011535896.1

    Conserved Domains (1) summary
    cl00456
    Location:52425
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  15. XM_011537581.1XP_011535883.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535883.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  16. XM_011537584.2XP_011535886.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535886.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  17. XM_011537590.1XP_011535892.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535892.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  18. XM_011537592.2XP_011535894.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535894.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  19. XM_011537586.2XP_011535888.1  proton-coupled amino acid transporter 1 isoform X2

    See identical proteins and their annotated locations for XP_011535888.1

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  20. XM_017009216.1XP_016864705.1  proton-coupled amino acid transporter 1 isoform X2

    UniProtKB/Swiss-Prot
    Q7Z2H8
    Conserved Domains (1) summary
    cl00456
    Location:47453
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  21. XM_011537595.2XP_011535897.2  proton-coupled amino acid transporter 1 isoform X4

  22. XM_011537580.2XP_011535882.1  proton-coupled amino acid transporter 1 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:53459
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  23. XM_017009218.1XP_016864707.1  proton-coupled amino acid transporter 1 isoform X8

  24. XM_011537596.2XP_011535898.2  proton-coupled amino acid transporter 1 isoform X10

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