Format

Send to:

Choose Destination

LVRN laeverin [ Homo sapiens (human) ]

Gene ID: 206338, updated on 5-Jan-2022

Summary

Official Symbol
LVRNprovided by HGNC
Official Full Name
laeverinprovided by HGNC
Primary source
HGNC:HGNC:26904
See related
Ensembl:ENSG00000172901 MIM:610046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APQ; AQPEP; TAQPEP
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in fat (RPKM 11.6), placenta (RPKM 10.8) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LVRN in Genome Data Viewer
Location:
5q23.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (115962475..116027606)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (115298172..115363303)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 3 subunit sigma 1 Neighboring gene lincRNA adipogenesis and lipogenesis associated Neighboring gene DEAD-box helicase 43 pseudogene 1 Neighboring gene ADP ribosylation factor like GTPase 14 effector protein like Neighboring gene ribosomal protein S25 pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 6 Neighboring gene COMM domain containing 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog
Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90650, MGC125378, MGC125379

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
aminopeptidase Q
Names
AP-Q
CHL2 antigen

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173800.5NP_776161.3  aminopeptidase Q

    See identical proteins and their annotated locations for NP_776161.3

    Status: VALIDATED

    Source sequence(s)
    AC010282, AC034236, AY560010, BC060869, BC109023, BX096521
    Consensus CDS
    CCDS4124.1
    UniProtKB/Swiss-Prot
    Q6Q4G3
    UniProtKB/TrEMBL
    Q0P5U8
    Related
    ENSP00000350541.4, ENST00000357872.9
    Conserved Domains (3) summary
    cd09601
    Location:105577
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:97506
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:648951
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    115962475..116027606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center