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Sst somatostatin [ Mus musculus (house mouse) ]

Gene ID: 20604, updated on 18-Apr-2024

Summary

Official Symbol
Sstprovided by MGI
Official Full Name
somatostatinprovided by MGI
Primary source
MGI:MGI:98326
See related
Ensembl:ENSMUSG00000004366 AllianceGenome:MGI:98326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SS; SOM; SRIF; Smst
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within regulation of cell migration. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; limb; nervous system; and sensory organ. Orthologous to human SST (somatostatin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 471.4), cortex adult (RPKM 146.8) and 9 other tissues See more
Orthologs
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Genomic context

Location:
16 B1; 16 15.0 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (23708327..23710041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23889573..23891342, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40448 Neighboring gene ATP-binding cassette, sub-family E (OABP), member 1 pseudogene Neighboring gene predicted gene, 31430 Neighboring gene STARR-seq mESC enhancer starr_40450 Neighboring gene STARR-seq mESC enhancer starr_40451 Neighboring gene STARR-seq mESC enhancer starr_40453 Neighboring gene receptor transporter protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr16:23982379-23982679 Neighboring gene STARR-positive B cell enhancer ABC_E10897 Neighboring gene B cell leukemia/lymphoma 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
somatostatin
Names
preprosomatostatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417475.1NP_001404404.1  somatostatin precursor

    Status: VALIDATED

    Source sequence(s)
    AC127241
    UniProtKB/Swiss-Prot
    P01167, P60041
    UniProtKB/TrEMBL
    Q545V6
  2. NM_009215.2NP_033241.1  somatostatin precursor

    See identical proteins and their annotated locations for NP_033241.1

    Status: VALIDATED

    Source sequence(s)
    AC127241
    Consensus CDS
    CCDS28080.1
    UniProtKB/Swiss-Prot
    P01167, P60041
    UniProtKB/TrEMBL
    Q545V6
    Related
    ENSMUSP00000004480.4, ENSMUST00000004480.5
    Conserved Domains (1) summary
    pfam03002
    Location:99116
    Somatostatin; Somatostatin/Cortistatin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    23708327..23710041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)