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Slc7a7 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 [ Mus musculus (house mouse) ]

Gene ID: 20540, updated on 8-Dec-2022

Summary

Official Symbol
Slc7a7provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7provided by MGI
Primary source
MGI:MGI:1337120
See related
Ensembl:ENSMUSG00000000958 AllianceGenome:MGI:1337120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
my+lat1
Summary
Enables basic amino acid transmembrane transporter activity. Acts upstream of or within regulation of arginine metabolic process. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in heart; intestine; metanephros; and testis. Human ortholog(s) of this gene implicated in lysinuric protein intolerance. Orthologous to human SLC7A7 (solute carrier family 7 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 116.6), large intestine adult (RPKM 74.7) and 8 other tissues See more
Orthologs
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Genomic context

See Slc7a7 in Genome Data Viewer
Location:
14; 14 C2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54606899..54657525, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54369442..54420068, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 43305 Neighboring gene eukaryotic translation initiation factor 4H pseudogene Neighboring gene oxidase assembly 1-like Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene matrix metallopeptidase 14 (membrane-inserted)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables basic amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables basic amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in leucine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of arginine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of arginine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Y+L amino acid transporter 1
Names
solute carrier family 7 member 7
y(+)L-type amino acid transporter 1
y+LAT-1
y+LAT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253679.1NP_001240608.1  Y+L amino acid transporter 1

    See identical proteins and their annotated locations for NP_001240608.1

    Status: VALIDATED

    Source sequence(s)
    AC206013
    Consensus CDS
    CCDS27087.1
    UniProtKB/Swiss-Prot
    Q9QWS1, Q9Z1K8
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Related
    ENSMUSP00000154533.2, ENSMUST00000226753.2
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  2. NM_001253680.1NP_001240609.1  Y+L amino acid transporter 1

    See identical proteins and their annotated locations for NP_001240609.1

    Status: VALIDATED

    Source sequence(s)
    AK152637, AV487330, CB953352
    Consensus CDS
    CCDS27087.1
    UniProtKB/Swiss-Prot
    Q9QWS1, Q9Z1K8
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Related
    ENSMUSP00000000984.5, ENSMUST00000000984.9
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  3. NM_001379497.1NP_001366426.1  Y+L amino acid transporter 1

    Status: VALIDATED

    Source sequence(s)
    AC206013
    UniProtKB/Swiss-Prot
    Q9QWS1
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  4. NM_001379498.1NP_001366427.1  Y+L amino acid transporter 1

    Status: VALIDATED

    Source sequence(s)
    AC206013
    UniProtKB/Swiss-Prot
    Q9QWS1
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  5. NM_001379499.1NP_001366428.1  Y+L amino acid transporter 1

    Status: VALIDATED

    Source sequence(s)
    AC206013
    UniProtKB/Swiss-Prot
    Q9QWS1
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Related
    ENSMUSP00000143091.2, ENSMUST00000195970.5
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  6. NM_011405.4NP_035535.2  Y+L amino acid transporter 1

    See identical proteins and their annotated locations for NP_035535.2

    Status: VALIDATED

    Source sequence(s)
    AK151718, AV487330, BY032471
    Consensus CDS
    CCDS27087.1
    UniProtKB/Swiss-Prot
    Q9QWS1, Q9Z1K8
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Related
    ENSMUSP00000143743.2, ENSMUST00000197440.5
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54606899..54657525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247702.1XP_030103562.1  Y+L amino acid transporter 1 isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:107580
    2A0308; L-type amino acid transporter
  2. XM_036158528.1XP_036014421.1  Y+L amino acid transporter 1 isoform X4

    UniProtKB/Swiss-Prot
    Q9QWS1
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  3. XM_006518752.2XP_006518815.1  Y+L amino acid transporter 1 isoform X4

    See identical proteins and their annotated locations for XP_006518815.1

    UniProtKB/Swiss-Prot
    Q9QWS1, Q9Z1K8
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  4. XM_006518746.2XP_006518809.1  Y+L amino acid transporter 1 isoform X2

    Conserved Domains (1) summary
    TIGR00911
    Location:44517
    2A0308; L-type amino acid transporter
  5. XM_006518751.3XP_006518814.1  Y+L amino acid transporter 1 isoform X4

    See identical proteins and their annotated locations for XP_006518814.1

    UniProtKB/Swiss-Prot
    Q9QWS1, Q9Z1K8
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  6. XM_006518753.1XP_006518816.1  Y+L amino acid transporter 1 isoform X4

    See identical proteins and their annotated locations for XP_006518816.1

    UniProtKB/Swiss-Prot
    Q9QWS1, Q9Z1K8
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  7. XM_006518755.5XP_006518818.1  Y+L amino acid transporter 1 isoform X4

    See identical proteins and their annotated locations for XP_006518818.1

    UniProtKB/Swiss-Prot
    Q9QWS1, Q9Z1K8
    UniProtKB/TrEMBL
    A0A8C6HAF7
    Conserved Domains (1) summary
    TIGR00911
    Location:21494
    2A0308; L-type amino acid transporter
  8. XM_030247703.1XP_030103563.1  Y+L amino acid transporter 1 isoform X3

    Conserved Domains (1) summary
    TIGR00911
    Location:42515
    2A0308; L-type amino acid transporter
  9. XM_030247705.1XP_030103565.1  Y+L amino acid transporter 1 isoform X5

    Conserved Domains (1) summary
    TIGR00911
    Location:3328
    2A0308; L-type amino acid transporter