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Slc3a1 solute carrier family 3, member 1 [ Mus musculus (house mouse) ]

Gene ID: 20532, updated on 8-Feb-2024

Summary

Official Symbol
Slc3a1provided by MGI
Official Full Name
solute carrier family 3, member 1provided by MGI
Primary source
MGI:MGI:1195264
See related
Ensembl:ENSMUSG00000024131 AllianceGenome:MGI:1195264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2; D2H; NBAT; NTAA; RBAT
Summary
Enables protein heterodimerization activity. Involved in amino acid transport and gene expression. Located in apical plasma membrane and brush border membrane. Is expressed in several structures, including brain; genitourinary system; integumental system; intestine; and respiratory system. Used to study cystinuria. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 126.1), large intestine adult (RPKM 44.6) and 10 other tissues See more
Orthologs
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Genomic context

See Slc3a1 in Genome Data Viewer
Location:
17 E4; 17 55.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (85335775..85371669)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (85028347..85064241)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43453 Neighboring gene post-GPI attachment to proteins 2 pseudogene Neighboring gene RIKEN cDNA 1110020A21 gene Neighboring gene STARR-seq mESC enhancer starr_43455 Neighboring gene STARR-seq mESC enhancer starr_43456 Neighboring gene STARR-positive B cell enhancer mm9_chr17:85356735-85357036 Neighboring gene STARR-seq mESC enhancer starr_43457 Neighboring gene protein phosphatase 1B, magnesium dependent, beta isoform Neighboring gene STARR-positive B cell enhancer ABC_E9445 Neighboring gene STARR-positive B cell enhancer ABC_E4233 Neighboring gene STARR-seq mESC enhancer starr_43458 Neighboring gene prolyl endopeptidase-like Neighboring gene calmodulin-lysine N-methyltransferase Neighboring gene STARR-seq mESC enhancer starr_43460 Neighboring gene STARR-seq mESC enhancer starr_43463 Neighboring gene STARR-positive B cell enhancer mm9_chr17:85588997-85589298 Neighboring gene STARR-seq mESC enhancer starr_43464 Neighboring gene predicted gene, 36826 Neighboring gene STARR-seq mESC enhancer starr_43465 Neighboring gene STARR-seq mESC enhancer starr_43466 Neighboring gene STARR-seq mESC enhancer starr_43468 Neighboring gene STARR-seq mESC enhancer starr_43469 Neighboring gene ribosomal protein L31, pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in L-cystine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-glutamate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in amino acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in aspartate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuolar membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
amino acid transporter heavy chain SLC3A1
Names
b(0,+)-type amino acid transport protein
b(0,+)-type amino acid transporter-related heavy chain
neutral and basic amino acid transport protein rBAT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009205.2NP_033231.2  amino acid transporter heavy chain SLC3A1

    See identical proteins and their annotated locations for NP_033231.2

    Status: VALIDATED

    Source sequence(s)
    AI326967, AK132275, CA493293
    Consensus CDS
    CCDS37711.1
    UniProtKB/Swiss-Prot
    Q91WV7
    UniProtKB/TrEMBL
    O55093
    Related
    ENSMUSP00000024944.8, ENSMUST00000024944.9
    Conserved Domains (3) summary
    cd11359
    Location:115568
    AmyAc_SLC3A1; Alpha amylase catalytic domain found in Solute Carrier family 3 member 1 proteins
    TIGR02403
    Location:116604
    trehalose_treC; alpha,alpha-phosphotrehalase
    pfam16028
    Location:64122
    SLC3A2_N; Solute carrier family 3 member 2 N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    85335775..85371669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)