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EPHB3 EPH receptor B3 [ Homo sapiens (human) ]

Gene ID: 2049, updated on 25-Nov-2021

Summary

Official Symbol
EPHB3provided by HGNC
Official Full Name
EPH receptor B3provided by HGNC
Primary source
HGNC:HGNC:3394
See related
Ensembl:ENSG00000182580 MIM:601839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EK2; ETK2; HEK2; TYRO6
Summary
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]
Expression
Broad expression in skin (RPKM 18.6), stomach (RPKM 10.2) and 15 other tissues See more
Orthologs
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Genomic context

See EPHB3 in Genome Data Viewer
Location:
3q27.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (184561785..184582408)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (184279573..184300196)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane epididymal protein 1 pseudogene Neighboring gene long intergenic non-protein coding RNA 1839 Neighboring gene long intergenic non-protein coding RNA 1840 Neighboring gene uncharacterized LOC107986163 Neighboring gene MAGE family member F1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables axon guidance receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axonal fasciculation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in central nervous system projection neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in corpus callosum development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in roof of mouth development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in urogenital system development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ephrin type-B receptor 3
Names
EPH-like tyrosine kinase 2
embryonic kinase 2
human embryo kinase 2
tyrosine-protein kinase TYRO6
NP_004434.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004443.4NP_004434.2  ephrin type-B receptor 3 precursor

    See identical proteins and their annotated locations for NP_004434.2

    Status: REVIEWED

    Source sequence(s)
    AC112643, BC052968, CB993133, X75208
    Consensus CDS
    CCDS3268.1
    UniProtKB/Swiss-Prot
    P54753
    Related
    ENSP00000332118.2, ENST00000330394.3
    Conserved Domains (7) summary
    cd05065
    Location:628896
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd10478
    Location:39211
    EphR_LBD_B3; Ligand Binding Domain of Ephrin type-B Receptor 3
    cd00063
    Location:473542
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07699
    Location:284316
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam00041
    Location:341436
    fn3; Fibronectin type III domain
    pfam14575
    Location:581628
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl15755
    Location:922990
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    184561785..184582408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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