Ski ski sarcoma viral oncogene homolog (avian) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Skiprovided by MGI
Official Full Name: ski sarcoma viral oncogene homolog (avian)provided by MGI
Primary source: MGI:MGI:98310
See related: Ensembl:ENSMUSG00000029050 AllianceGenome:MGI:98310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310012I02Rik; 2610001A11Rik
Summary: Enables chromatin binding activity and histone deacetylase inhibitor activity. Acts upstream of or within several processes, including animal organ development; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription repressor complex. Is expressed in embryo; forelimb bud; and forelimb interdigital region. Orthologous to human SKI (SKI proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 51.4), adrenal adult (RPKM 44.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 86.17 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (155238532..155306992, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (155154075..155222535, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpressed ski efficiently promotes neurorestoration, increases neuronal regeneration, and reduces astrogliosis after traumatic brain injury.
Title: Overexpressed ski efficiently promotes neurorestoration, increases neuronal regeneration, and reduces astrogliosis after traumatic brain injury.
The SKI proto-oncogene restrains the resident CD103(+)CD8(+) T cell response in viral clearance.
Title: The SKI proto-oncogene restrains the resident CD103(+)CD8(+) T cell response in viral clearance.
study reveals a critical mechanism by which TGFbeta controls TH17 cell differentiation and uncovers the SKI-SMAD4 axis as a potential therapeutic target for treating TH17-related diseases
Title: Reversing SKI-SMAD4-mediated suppression is essential for T(H)17 cell differentiation.
our results demonstrate that SKI is an important regulator of hematopoietic stem cell activity and its overexpression leads to myeloproliferative disease.
Title: The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.
Trnsgenic mice overexpressing chicken Ski (c-Ski) have marked decrease in adipose mass with skeletal muscle hypertrophy Results suggest Ski plays a major role in skeletal muscle metabolism and adipogenesis and hence influences risk of obesity and diabetes
Title: Ski overexpression in skeletal muscle modulates genetic programs that control susceptibility to diet-induced obesity and insulin signaling.
After Qingyi Huaji treatment, Ski expression was reduced and pancreatic tumor growth slowed down significantly.
Title: [Effect of Qingyi Huaji formula for inhibition of pancreatic cancer cell growth through down-regulating Ski expression].
Satb2 recruits Ski to the Ctip2 locus, and Ski attracts histone deacetylases, thereby enabling the formation of a functional nucleosome remodeling and deacetylase repressor complex.
Title: Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.
Data on expression of Ski suggest that Ski is involved in follicular development, oogenesis, ovulation, and luteinization. During the estrous cycle, Ski expression was apparent at proestrus and estrus, faint at metestrus, highest at diestrus.
Title: Relationship between Sloan-Kettering virus expression and mouse follicular development.
The presented data support a new role for Ski in the mitotic process and in maintenance of genetic stability
Title: Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.
Ski regulates several genetic programs and signalling pathways that regulate skeletal muscle and adipose mass to influence body composition development, suggesting that Ski may have a role in risk for obesity and metabolic disease.
Title: The Ski proto-oncogene regulates body composition and suppresses lipogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124748 (e-PCR)
- UniSTS:161570

NoName (e-PCR)
- UniSTS:235115

RH126860 (e-PCR)
- UniSTS:207740

D4Smh6b (e-PCR), detects polymorphism
- UniSTS:142487

RH141172 (e-PCR)
- UniSTS:223168

RH124969 (e-PCR)
- UniSTS:161791

Homology

Homologs of the Ski gene: The Ski gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 478 organisms have orthologs with human gene Ski
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables histone deacetylase inhibitor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination in peripheral nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within myotube differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Schwann cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nose morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ski oncogene

Names: C-ski; Sloan-Kettering viral oncogene homolog; proto-oncogene c-Ski

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357191.1 → NP_001344120.1 ski oncogene isoform 2

Status: VALIDATED

Source sequence(s)

AL670413, AW491584, CA750434, CB522577, CB722801, CN526656

Conserved Domains (3) summary

smart01046
Location:217 → 312

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam02437
Location:92 → 190

Ski_Sno; SKI/SNO/DAC family

cl25732
Location:496 → 668

SMC_N; RecF/RecN/SMC N terminal domain
NM_011385.2 → NP_035515.2 ski oncogene isoform 1

See identical proteins and their annotated locations for NP_035515.2

Status: VALIDATED

Source sequence(s)

AL670413, AW491584, CA451127, CA750434, CB722801, CN526656

Consensus CDS

CCDS19024.1

UniProtKB/TrEMBL

B1AUF1

Related

ENSMUSP00000030917.6, ENSMUST00000030917.6

Conserved Domains (5) summary

pfam02437
Location:92 → 190

Ski_Sno; SKI/SNO/DAC family

pfam07321
Location:562 → 698

YscO; Type III secretion protein YscO

pfam08782
Location:219 → 311

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

pfam13863
Location:595 → 701

DUF4200; Domain of unknown function (DUF4200)

cl12013
Location:542 → 604

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature