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EPHB1 EPH receptor B1 [ Homo sapiens (human) ]

Gene ID: 2047, updated on 27-Nov-2024

Summary

Official Symbol
EPHB1provided by HGNC
Official Full Name
EPH receptor B1provided by HGNC
Primary source
HGNC:HGNC:3392
See related
Ensembl:ENSG00000154928 MIM:600600; AllianceGenome:HGNC:3392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELK; NET; Hek6; EPHT2
Summary
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 6.3), testis (RPKM 3.5) and 8 other tissues See more
Orthologs
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Genomic context

See EPHB1 in Genome Data Viewer
Location:
3q22.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (134795260..135260467)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (137540631..138005927)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134514102..134979309)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene centrosomal protein 63 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20567 Neighboring gene Sharpr-MPRA regulatory region 6102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20570 Neighboring gene RNA, U6 small nuclear 1174, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134565355-134565854 Neighboring gene uncharacterized LOC105374121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20575 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:134610984-134611623 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:134660519-134661204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134723970-134724470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134724471-134724971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134737937-134738437 Neighboring gene uncharacterized LOC102724019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20577 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:134968182-134968385 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134976165-134976780 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134976781-134977396 Neighboring gene uncharacterized LOC105374122 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:135171489-135171996 Neighboring gene Sharpr-MPRA regulatory region 765 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:135232323-135233522 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:135377721-135378306 Neighboring gene uncharacterized LOC105374123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20578

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ37986

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GPI-linked ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables axon guidance receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables boss receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables brain-derived neurotrophic factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables hepatocyte growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables macrophage colony-stimulating factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables placental growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables platelet-derived growth factor alpha-receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables platelet-derived growth factor beta-receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase collagen receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables stem cell factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane-ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in central nervous system projection neuron axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in detection of temperature stimulus involved in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in hindbrain tangential cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in immunological synapse formation IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of satellite cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of skeletal muscle satellite cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in optic nerve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in skeletal muscle satellite cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in filopodium tip IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ephrin type-B receptor 1
Names
EK6
EPH-like kinase 6
eph tyrosine kinase 2
neuronally-expressed EPH-related tyrosine kinase
tyrosine-protein kinase receptor EPH-2
NP_004432.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004441.5NP_004432.1  ephrin type-B receptor 1 precursor

    See identical proteins and their annotated locations for NP_004432.1

    Status: REVIEWED

    Source sequence(s)
    AC016931, AC016951, AC073244, AC092969
    Consensus CDS
    CCDS46921.1
    UniProtKB/Swiss-Prot
    A8K593, B3KTB2, B5A969, O43569, O95142, O95143, P54762, Q0VG87
    UniProtKB/TrEMBL
    A0A3B3IRY8
    Related
    ENSP00000381097.3, ENST00000398015.8
    Conserved Domains (8) summary
    cd05065
    Location:614882
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09551
    Location:908975
    SAM_EPH-B1; SAM domain of EPH-B1 subfamily of tyrosine kinase receptors
    smart00454
    Location:908973
    SAM; Sterile alpha motif
    cd10476
    Location:20195
    EphR_LBD_B1; Ligand Binding Domain of Ephrin type-B Receptor 1
    cd00063
    Location:323429
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:435518
    fn3; Fibronectin type III domain
    pfam07714
    Location:619878
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:546614
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    134795260..135260467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    137540631..138005927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)